Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| GREM1 | 26585 | gremlin 1, DAN family BMP antagonist | 15 | DRM, gremlin, DAND2, HMPS |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25992589 | 2015 | Cell line : - Source : Ewish Ashkenazi Sample Type : - No. of Sample : 194 with CRC and 147 control Stage : - | - | Mutation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010] |
| Chromosome | 15 |
| Location | 15q13.3 |
| Start | 33010175 |
| End | 33026870 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 16696 |
| OMIM ID | 603054 |
| HGNC ID | HGNC:2001 |
| Unigene ID | Hs.40098 |
| Ensembl ID | ENSG00000166923 |
| PharmGKB ID | PA26537 |
Protein Information
| Protein ID | NP_001178252.1 |
|---|---|
| Protein Name | gremlin 1, DAN family BMP antagonist |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 184 |
| Uniprot ID | Q86VI4 |
| Ensembl Protein ID | ENSP00000402301 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 77 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam03045 | 68-184 | DAN |
| cl21545 | 68-184 | GHB_like superfamily |
| smart00041 | 96-181 | CT |
Ontology Information
| HPRD ID | 5978 |
|---|---|
| Molecular Class | Secreted polypeptide |
| Molecular Function | G-protein coupled receptor activity (GO:0004930) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.