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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| HAVCR1 | 26762 | hepatitis A virus cellular receptor 1 | 5 | HAVCR-1, TIM-1, TIM1, HAVCR, TIMD1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23267147 | 2013 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | real time RT-PCR | Up-regulation | - | HAVcR-1 overexpression may be a diagnostic biomarker for colorectal cancer and a prognostic marker for a longer disease-free interval after surgery for colorectal cancer. HAVcR-1 overexpression can reduce cell adhesion and invasion and could thus be involved in the metastatic cascade. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Immunoglobulin superfamily / V-set domain containing |
| Description | The protein encoded by this gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. The encoded protein may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 4, 12 and 19. |
| Chromosome | 5 |
| Location | 5q33.2 |
| Start | 156979480 |
| End | 157069527 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 90048 |
| OMIM ID | 606518 |
| HGNC ID | HGNC:17866 |
| Unigene ID | Hs.129711 |
| Ensembl ID | ENSG00000113249 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_011534513.1 |
|---|---|
| Exon | join(1..169,11573..11630,13995..14327,16874..17167, 20383..20490,26846..26901,32167..32281,39687..40577) | mRNA Sequence | Download Select all |
| Length | 1626 |
CDS Information
| Location | join(11585..11630,13995..14327,16874..17167,20383..20490, 26846..26901,32167..32281,39687..39940) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | XP_006714903.1 |
|---|---|
| Protein Name | hepatitis A virus cellular receptor 1 |
| Molecular Wt. (Da) | 43871 |
| Protein Sequence | Download Select all |
| Length | 401 |
| Uniprot ID | P52292 |
| Ensembl Protein ID | ENSP00000332455 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| N | Glycosylation | 65 |
| S | Phosphorylation | 228 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 56893 | UBQLN4 | 5670 | NP_064516.2 | yeast 2-hybrid | 16713569 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd05714 | 29-124 | Ig_CSPGs_LP |
| cl11960 | 29-124 | Ig superfamily |
| cd05716 | 23-125 | Ig_pIgR |
| cd00096 | 32-111 | Ig |
| cd05712 | 22-124 | Ig_Siglec_N |
| cd00099 | 20-120 | IgV |
| smart00406 | 31-105 | IGv |
| cd05877 | 29-124 | Ig_LP_like |
| cd05715 | 24-107 | Ig_P0-like |
| cd07690 | 24-122 | Ig1_CD4 |
| cd05713 | 29-114 | Ig_MOG_like |
| smart00410 | 21-108 | IG_like |
| smart00409 | 21-108 | IG |
Ontology Information
| HPRD ID | 3536 |
|---|---|
| Molecular Class | Cell surface receptor |
| Molecular Function | Transporter activity (GO:0005215) |
| Biological Process | Transport (GO:0006810) |
Drug Information
No matching records could be found.