Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| GH1 | 2688 | Growth hormone 1 | 17 | GH; GHN; GH-N; hGH-N; IGHD1B |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19064544 | 2008 | Cell line : - Source : Northern Israel. Sample Type : Population-based case-control study No. of Sample : 3,041 (1,402 cases and 1,639 controls) Stage : - | Genotyping | Polymorhpism | - | An allele of the rs2665802 polymorphism is associated with reduced risk of CRC only among physically inactive individuals, indicating an interaction between physical activity and the growth hormone/IGF-I system. |
| 11904318 | 2002 | Cell line : - Source : Hawaii Sample Type : Population-based case-control study No. of Sample : 535 case patients with colorectal adenocarcinoma and 650 control subjects and a sigmoidoscopy screening-based study with 139 case patients with adenoma and 202 control subjects. Stage : - | Sigmoidoscopy screening-based study. | Polymorhpism | - | The human T1663A GH1 gene polymorphism, which may confer lower levels of GH and IGF-I, appears to be associated with a decreased risk of colorectal cancer. Analyzed data from two case-control studies conducted in Hawaii: a population-based study of 535 case patients with colorectal adenocarcinoma and 650 control subjects and a sigmoidoscopy screening-based study with 139 case patients with adenoma and 202 control subjects. |
| 20168335 | 2010 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | PCR-RFLP | Polymorhpism | - | - |
| 20580999 | 2010 | Cell line : - Source : Patients in Wshington. Sample Type : - No. of Sample : Cases with colorectal adenomas 519, hyperplastic polyps 691, or both lesions 227, and controls 772, Stage : - | Genotyping | Polymorhpism | - | Some genetic variation in GH1 might contribute to a reduced risk of colorectal adenomas and hyperplastic polyps. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. [provided by RefSeq, Jul 2008] |
| Chromosome | 17 |
| Location | 17q24.2 |
| Start | 63917193 |
| End | 63918852 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 1660 |
| OMIM ID | 139250 |
| HGNC ID | HGNC:4261 |
| Unigene ID | Hs.655229 |
| Ensembl ID | ENSG00000259384 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_022560.3 |
|---|---|
| Exon | join(1..86,347..507,929..1093,1347..1660) | mRNA Sequence | Download Select all |
| Length | 777 |
CDS Information
| Location | join(77..82,343..507,717..836,929..1093,1347..1544) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_000506.2 |
|---|---|
| Protein Name | Growth hormone 1 |
| Molecular Wt. (Da) | 22129 |
| Protein Sequence | Download Select all |
| Length | 217 |
| Uniprot ID | P51813 |
| Ensembl Protein ID | ENSP00000340082 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 132 |
| S | Phosphorylation | 176 |
| C | Disulfide Bridge | 208;215 |
| C | Disulfide Bridge | 79;191 |
| S | Phosphorylation | 117 |
| S | Phosphorylation | 161 |
| S | Phosphorylation | 136 |
| S | Phosphorylation | 92 |
| S | Phosphorylation | 81 |
Enzyme Information
| EC | 3.2.1.21 |
|---|---|
| Name | beta-glucosidase gentiobiase cellobiase emulsin elaterase aryl-beta-glucosidase beta-D-glucosidase beta-glucoside glucohydrolase arbutinase amygdalinase p-nitrophenyl beta-glucosidase primeverosidase amygdalase linamarase salicilinase beta-1,6-glucosidase |
| Class | Hydrolases; Glycosylases; Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds |
| Sysname | beta-D-glucoside glucohydrolase |
| Substrate | |
| Product | |
| Reaction (IUBMB) |  |
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cytokine-cytokine receptor interaction | hsa04060 |
| Jak-STAT signaling pathway | hsa04630 |
| Neuroactive ligand-receptor interaction | hsa04080 |
| PI3K-Akt signaling pathway | hsa04151 |
Structure Information
| PDB ID | 1A22 |
|---|---|
| Resolution | 2.3 |
| Method | X-RAY DIFFRACTION |
| Chains | A |
| Molecule | GROWTH HORMONE |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd10285 | 35-215 | somatotropin_like |
| cl07831 | 35-215 | growth_hormone_like superfamily |
| cd10284 | 35-215 | growth_hormone_like |
| pfam00103 | 30-215 | Hormone_1 |
| cd10286 | 22-215 | somatolactin |
| cd10288 | 30-214 | prolactin_like |
| cd10287 | 32-215 | prolactin_2 |
Ontology Information
| HPRD ID | 2111 |
|---|---|
| Molecular Class | Cytokine |
| Molecular Function | Protein-tyrosine kinase activity (GO:0004713) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.