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General Information
- Evidence
- Gene
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- Enzyme
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17764692 | 2007 | Cell line : - Source : - Sample Type : CRC tumor and adjacent normal tissues No. of Sample : 90 Stage : - | RT-PCR,immunohistochemistry | Up-regulation | - | Growth hormone/GHR plays a role in the development of colorectal carcinoma. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Fibronectin type III domain containing |
| Description | This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011] |
| Chromosome | 5 |
| Location | 5p14-p12 |
| Start | 42423577 |
| End | 42721980 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 298404 |
| OMIM ID | 600946 |
| HGNC ID | HGNC:4263 |
| Unigene ID | Hs.125180 |
| Ensembl ID | ENSG00000112964 |
| PharmGKB ID | PA28674 |
mRNA Information
| mRNA ID | NM_000163.4 |
|---|---|
| Exon | join(1..181,142090..142170,205264..205329,265116..265245, 271143..271315,276050..276228,287433..287598, 289655..289745,294278..294347,294679..298104) | mRNA Sequence | Download Select all |
| Length | 4563 |
Protein Information
| Protein ID | NP_000154.1 |
|---|---|
| Protein Name | growth hormone receptor |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 638 |
| Uniprot ID | Q13464 |
| Ensembl Protein ID | ENSP00000382697 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 332 |
| Y | Phosphorylation | 487 |
| Y | Phosphorylation | 534 |
| Y | Phosphorylation | 566 |
| Y | Phosphorylation | 627 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1154 | CISH | 3897 | NP_037456.5 | in vitro;in vivo | 12586763 |
| 2689 | GH2 | 750 | NP_072051.1 | in vivo | 1955498 |
| 2885 | GRB2 | 150 | NP_002077.1 | in vivo | 9632636 |
| 3716 | JAK1 | 992 | NP_002218.2 | in vitro;in vivo | 10502458 |
| 3717 | JAK2 | 993 | NP_004963.1 | in vivo | 7 540 178 105 024 580 000 000 |
| 5295 | PIK3R1 | 1381 | NP_852664.1 | in vivo | 9632636 |
| 5777 | PTPN6 | 1475 | NP_536859.1 | in vivo | 9632636 |
| 5781 | PTPN11 | 1470 | NP_002825.3 | in vivo | 10976913 |
| 6464 | SHC1 | 2780 | NP_001123512.1 | in vivo | 9632636 |
| 6774 | STAT3 | 26 | NP_644805.1 | in vivo | 8923468 |
| 7297 | TYK2 | 1490 | NP_003322.3 | in vivo | 10502458 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cytokine-cytokine receptor interaction | hsa04060 |
| Jak-STAT signaling pathway | hsa04630 |
| Neuroactive ligand-receptor interaction | hsa04080 |
| PI3K-Akt signaling pathway | hsa04151 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00063 | 149-250 | FN3 |
| cl21522 | 149-250 | FN3 superfamily |
| pfam12772 | 316-621 | GHBP |
| cl15082 | 316-621 | GHBP superfamily |
| pfam09067 | 49-127 | EpoR_lig-bind |
| cl21522 | 49-127 | FN3 superfamily |
| smart00060 | 149-241 | FN3 |
| pfam00041 | 161-244 | fn3 |
Ontology Information
| HPRD ID | 2896 |
|---|---|
| Molecular Class | Cell surface receptor |
| Molecular Function | DNA binding (GO:0003677) |
| Biological Process | Bone remodeling (GO:0046849) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P10912 | DB00052 | Somatropin recombinant | BiotechDrug |
| P10912 | DB00082 | Pegvisomant | BiotechDrug |