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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20433877 | 2010 | Cell line : - Source : Biospecimen Archive Research Core at Boston University School of Medicine and cut into 7m sections. Sample Type : CRC tumor and normal tissues No. of Sample : - Stage : TNM Stage II-IV | RT-PCR and Western blotting | Up-regulation | - | The overexpression of GIP, which occurs in obesity, might thereby be contributing to the enhanced rate of carcinogenesis observed in obesity. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Endogenous ligands |
| Description | This gene encodes an incretin hormone and belongs to the glucagon superfamily. The encoded protein is important in maintaining glucose homeostasis as it is a potent stimulator of insulin secretion from pancreatic beta-cells following food ingestion and nutrient absorption. This gene stimulates insulin secretion via its G protein-coupled receptor activation of adenylyl cyclase and other signal transduction pathways. It is a relatively poor inhibitor of gastric acid secretion. [provided by RefSeq, Jul 2008] |
| Chromosome | 17 |
| Location | 17q21.3-q2 |
| Start | 47035918 |
| End | 47045955 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 10038 |
| OMIM ID | 137240 |
| HGNC ID | HGNC:4270 |
| Unigene ID | Hs.1454 |
| Ensembl ID | ENSG00000159224 |
| PharmGKB ID | PA28681 |
mRNA Information
| mRNA ID | NM_004123.2 |
|---|---|
| Exon | join(1..77,1341..1447,4114..4284,6775..6867,7607..7708, 9878..10038) | mRNA Sequence | Download Select all |
| Length | 711 |
Protein Information
| Protein ID | NP_004114.1 |
|---|---|
| Protein Name | gastric inhibitory polypeptide |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 153 |
| Uniprot ID | P27694 |
| Ensembl Protein ID | ENSP00000254719 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2696 | GIPR | 670 | NP_000155.1 | in vivo | 156 557 078 795 084 000 000 000 000 000 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Insulin secretion | hsa04911 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00123 | 52-79 | Hormone_2 |
| cl23492 | 52-79 | Hormone_2 superfamily |
| smart00070 | 52-78 | GLUCA |
| cl23044 | 52-78 | GLUCA superfamily |
Ontology Information
| HPRD ID | 1594 |
|---|---|
| Molecular Class | Peptide hormone |
| Molecular Function | Structural constituent of ribosome (GO:0003735) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.