Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PELP1 | 27043 | proline, glutamate and leucine rich protein 1 | 17 | MNAR |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19478391 | 2009 | Cell line : - Source : - Sample Type : CRC tumor No. of Sample : 113 Stage : - | - | Up-regulation | - | ERbeta and PELP1/MNAR appear to be involved in colorectal tumorigenesis and might have prognostic significance. |
| 24967003 | 2014 | Cell line : COLO205, HT 29, SW 620, HCC 2998, HCT 15, FHC Source : ATCC Sample Type : - No. of Sample : - Stage : - | MTT,real time RT-PCR,western blotting, Plate Colony Forming Assay,Transwell Small Chamber Invasion and Migration Assay | Up-regulation | - | PELP1 exhibits an oncogenic function in colorectal cancer through c-Src upregulation. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a transcription factor which coactivates transcription of estrogen receptor responsive genes and corepresses genes activated by other hormone receptors or sequence-specific transcription factors. Expression of this gene is regulated by both members of the estrogen receptor family. This gene may be involved in the progression of several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013] |
| Chromosome | 17 |
| Location | 17p13.2 |
| Start | 4574679 |
| End | 4607712 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 33034 |
| OMIM ID | 609455 |
| HGNC ID | HGNC:30134 |
| Unigene ID | Hs.744899 |
| Ensembl ID | - |
| PharmGKB ID | PA142671186 |
Protein Information
| Protein ID | NP_001265170.1 |
|---|---|
| Protein Name | proline, glutamate and leucine rich protein 1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 1130 |
| Uniprot ID | Q9BXB1 |
| Ensembl Protein ID | ENSP00000368516 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 745 |
| S | Phosphorylation | 1033;- |
| S | Phosphorylation | 743;- |
| T | Phosphorylation | 749;- |
| S | Phosphorylation | 481;- |
| S | Phosphorylation | 477;- |
| S | Phosphorylation | 485;- |
| T | Phosphorylation | 488;- |
| S | Phosphorylation | 1043 |
| T | Phosphorylation | 1090 |
| T | Phosphorylation | 1105 |
| S | Phosphorylation | 7 |
| S | Phosphorylation | 1073 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 367 | AR | 2437 | NP_000035.2 | in vitro | 12415108 |
| 2033 | EP300 | 4078 | NP_001420.2 | in vivo | 11481323 |
| 2099 | ESR1 | 589 | NP_000116.2 | in vitro;in vivo | 11481323 |
| 2908 | NR3C1 | 679 | NP_001019265.1 | in vitro | 12415108 |
| 4093 | SMAD9 | 4484 | BAA21128.1 | yeast 2-hybrid | 15231748 |
| 5925 | RB1 | 1574 | NP_000312.2 | in vitro;in vivo | 12682072 |
| 6714 | SRC | 1819 | NP_005408.1 | in vivo | 12415108 |
| 9146 | HGS | 5085 | NP_004703.1 | in vitro;in vivo;yeast 2-hybrid | 16352611 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam08167 | 66-226 | RIX1 |
| cl20353 | 66-226 | RIX1 superfamily |
| pfam08166 | 423-489 | NUC202 |
| cl06974 | 423-489 | NUC202 superfamily |
| pfam08166 | 569-637 | NUC202 |
| cl06974 | 569-637 | NUC202 superfamily |
| PHA03247 | 678-763 | PHA03247 |
Ontology Information
| HPRD ID | 13627 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Cell proliferation (GO:0008283) |
Drug Information
No matching records could be found.