Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CACYBP | 27101 | calcyclin binding protein | 1 | SIP, S100A6BP |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23543800 | 2013 | Cell line : HCT116, SW620 Source : - Sample Type : - No. of Sample : - Stage : - | Generation of CacyBP Overexpression Construct,Generation of CacyBP- Knock-down Construct ,Cell Transfection and Generation of Stable Cell Lines with CacyBP Overexpression and Knock-down ,Western Blot and Immunofluorescence. | Up-regulation | - | CacyBP a promising candidate biomarker for CRC metastasis and also sheds light on the underlying molecular mechanism by which CacyBP promotes CRC metastasis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Chromosome | 1 |
| Location | 1q24-q25 |
| Start | 174968571 |
| End | 174981163 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 12593 |
| OMIM ID | 606186 |
| HGNC ID | HGNC:30423 |
| Unigene ID | Hs.508524 |
| Ensembl ID | ENSG00000116161 |
| PharmGKB ID | PA134894213 |
Protein Information
| Protein ID | NP_001007215.1 |
|---|---|
| Protein Name | calcyclin binding protein |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 228 |
| Uniprot ID | Q9P2D1 |
| Ensembl Protein ID | ENSP00000392028 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 209 |
| T | Phosphorylation | 166 |
| K | Acetylation | 8 |
| K | Acetylation | 19 |
| K | Acetylation | 118 |
| K | Acetylation | 75 |
| K | Acetylation | 85 |
| K | Acetylation | 42 |
| K | Acetylation | 134 |
| K | Acetylation | 91 |
| Y | Phosphorylation | 199 |
| Y | Phosphorylation | 156 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 6271 | S100A1 | 1489 | NP_006262.1 | in vivo | 12042313 |
| 6277 | S100A6 | 237 | NP_055439.1 | in vivo | 12042313 |
| 6283 | S100A12 | 4383 | NP_005612.1 | in vivo | 12042313 |
| 6285 | S100B | 1505 | NP_006263.1 | in vitro;in vivo | 12042313 |
| 6286 | S100P | 2792 | NP_005971.1 | in vivo | 12042313 |
| 6477 | SIAH1 | 3736 | NP_001006611.1 | in vitro;in vivo;yeast 2-hybrid | 11389839 |
| 6478 | SIAH2 | 3737 | NP_005058.3 | in vitro;yeast 2-hybrid | 11389839 |
| 6500 | SKP1 | 3255 | NP_733779.1 | in vitro;in vivo;yeast 2-hybrid | 11389839 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Wnt signaling pathway | hsa04310 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd06468 | 75-167 | p23_CacyBP |
| cl00175 | 75-167 | alpha-crystallin-Hsps_p23-like superfamily |
| pfam09032 | Apr-75 | Siah-Interact_N |
| cl07592 | Apr-75 | Siah-Interact_N superfamily |
| pfam04969 | 77-156 | CS |
| cd06463 | 80-167 | p23_like |
| pfam05002 | 163-218 | SGS |
| cl04882 | 163-218 | SGS superfamily |
| cd06489 | 80-167 | p23_CS_hSgt1_like |
| cd06465 | 80-168 | p23_hB-ind1_like |
| COG5091 | 8-217 | SGT1 |
| PTZ00121 | Mar-63 | PTZ00121 |
Ontology Information
| HPRD ID | 7946 |
|---|---|
| Molecular Class | Ubiquitin proteasome system protein |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
No matching records could be found.