Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| DKK3 | 27122 | dickkopf WNT signaling pathway inhibitor 3 | 11 | REIC, RIG |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22529687 | 2012 | Cell line : HT 29, LoVo, SW480 Source : - Sample Type : - No. of Sample : - Stage : - | RT-PCR,Western blotting ,Cell proliferation assay, cell cycle analysis, hoechst 33258 assay and Matrigel invasion assay | Up-regulation | - | Dkk-3 may be involved in the Wnt/?-catenin signaling pathways in colon cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] |
| Chromosome | 11 |
| Location | 11p15.3 |
| Start | 11984543 |
| End | 12031373 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 46831 |
| OMIM ID | 605416 |
| HGNC ID | HGNC:2893 |
| Unigene ID | Hs.292156 |
| Ensembl ID | ENSG00000050165 |
| PharmGKB ID | PA27347 |
Protein Information
| Protein ID | NP_001018067.1 |
|---|---|
| Protein Name | dickkopf WNT signaling pathway inhibitor 3 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 350 |
| Uniprot ID | Q9NX58 |
| Ensembl Protein ID | ENSP00000345917 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 56893 | UBQLN4 | 5670 | NP_064516.2 | yeast 2-hybrid | 16713569 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam04706 | 146-197 | Dickkopf_N |
| cl04692 | 146-197 | Dickkopf_N superfamily |
| pfam06607 | 208-273 | Prokineticin |
| cl05897 | 208-273 | Prokineticin superfamily |
| pfam11703 | 139-196 | UPF0506 |
| cl13198 | 139-196 | UPF0506 superfamily |
Ontology Information
| HPRD ID | 11131 |
|---|---|
| Molecular Class | Ligand |
| Molecular Function | Structural constituent of cytoskeleton (GO:0005200) |
| Biological Process | Cell growth and/or maintenance (GO:0008151); Cell migration (GO:0016477) |
Drug Information
No matching records could be found.