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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| AGO2 | 27161 | argonaute RISC catalytic component 2 | 8 | hAGO2, Q10 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20146808 | 2010 | Cell line : - Source : Department of Surgical Gastroenterology, the Tongji Hospital of Tongji University and National Engineering Center for Biochip at Shanghai. Sample Type : CRC tumor and normal tissue No. of Sample : 90 Stage : - | Tissue microarray,immunohistochemistry | Up-regulation | - | The expression of EIF2C2-4 and PIWIL4 appears increased in advanced tumors with distant metastasis, suggesting it may promote tumor invasion. |
| 23411422 | 2013 | Cell line : - Source : Shanghai Outdo Biotech Co., Ltd. � Sample Type : CRC tumor and normal tissues No. of Sample : 75 Stage : Duke stage A-D | Tissue microarray | Up-regulation | - | Abnormal expression of Argonaute2 (EIF2C2) may be correlated with colon tumorigenesis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Argonaute/PIWI family |
| Description | This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Chromosome | 8 |
| Location | 8q24.3 |
| Start | 140520156 |
| End | 140642326 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 122171 |
| OMIM ID | 606229 |
| HGNC ID | HGNC:3263 |
| Unigene ID | Hs.743313 |
| Ensembl ID | ENSG00000123908 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_011516968.1 |
|---|---|
| Exon | join(1..134,57016..57208,69395..69515,79693..79874, 81817..81953,82798..82932,83755..83842,85091..85238, 86041..86160,86309..86431,90891..91024,93029..93213, 94700..94859,98024..98114,100969..101163,102873..103007, 106758..106859,109712..109911,110175..122171) | mRNA Sequence | Download Select all |
| Length | 3418 |
CDS Information
| Location | join(6821..6842,57016..57208,69395..69515,79693..79874, 81817..81953,82798..82932,83755..83842,85091..85238, 86041..86160,86309..86431,90891..91024,93029..93213, 94700..94859,98024..98114,100969..101163,102873..103007, 109712..109911,110175..110283) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS55279.1 |
Protein Information
| Protein ID | NP_001158095.1 |
|---|---|
| Protein Name | argonaute RISC catalytic component 2 |
| Molecular Wt. (Da) | 93489 |
| Protein Sequence | Download Select all |
| Length | 825 |
| Uniprot ID | O00505 |
| Ensembl Protein ID | ENSP00000261667 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 387 |
| S | Phosphorylation | 824 |
| T | Phosphorylation | 251 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 11218 | DDX20 | 5859 | NP_009135.4 | in vitro;in vivo | 1 191 427 714 970 380 |
| 23405 | DICER1 | 5875 | NP_803187.1 | in vivo | 12526743 |
Pathway Information
No matching records could be found.
Structure Information
| PDB ID | 3LUC |
|---|---|
| Resolution | 1.69 |
| Method | X-RAY DIFFRACTION |
| Chains | A,B,C |
| Molecule | Protein argonaute-2 |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd04657 | 392-817 | Piwi_ago-like |
| cl00628 | 392-817 | Piwi-like superfamily |
| cd02846 | 227-347 | PAZ_argonaute_like |
| cl00301 | 227-347 | PAZ superfamily |
| cd02826 | 392-815 | Piwi-like |
| smart00950 | 517-818 | Piwi |
| pfam02171 | 517-818 | Piwi |
| cd04658 | 368-811 | Piwi_piwi-like_Euk |
| pfam02170 | 235-354 | PAZ |
| cd02825 | 227-347 | PAZ |
| pfam08699 | 175-227 | DUF1785 |
| cl07356 | 175-227 | DUF1785 superfamily |
| smart00949 | 235-369 | PAZ |
| cd04659 | 506-810 | Piwi_piwi-like_ProArk |
| PLN03202 | 25-858 | PLN03202 |
Ontology Information
| HPRD ID | 3597 |
|---|---|
| Molecular Class | Translation regulatory protein |
| Molecular Function | Transporter activity (GO:0005215) |
| Biological Process | Transport (GO:0006810) |
Drug Information
No matching records could be found.