Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| GLS2 | 27165 | glutaminase 2 (liver, mitochondrial) | 12 | GA, GLS, LGA, hLGA |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24330717 | 2013 | Cell line : HT-29, SW480, SW620, HCT116, LoVo, WiDr Source : ATCC, Huashan Hospital (Shanghai, China) Sample Type : CRC tumor and normal tissue No. of Sample : 5 Stage : - | Real-time PCR ,bisulfite genome sequencing,Methylation-specific PCR | Methylation | - | Epigenetic silencing of Gls2 via promoter hypermethylation is common in human liver and colon cancers and Gls2 appears to be a functional tumor suppressor involved in the liver and colon tumorigenesis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Ankyrin repeat domain containing |
| Description | The protein encoded by this gene is a mitochondrial phosphate-activated glutaminase that catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. Originally thought to be liver-specific, this protein has been found in other tissues as well. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013] |
| Chromosome | 12 |
| Location | 12q13 |
| Start | 56864728 |
| End | 56882198 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 17471 |
| OMIM ID | 606365 |
| HGNC ID | HGNC:29570 |
| Unigene ID | Hs.212606 |
| Ensembl ID | ENSG00000135423 |
| PharmGKB ID | PA134933506 |
Protein Information
| Protein ID | NP_001267727.1 |
|---|---|
| Protein Name | glutaminase 2 (liver, mitochondrial) |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 602 |
| Uniprot ID | Q3BBV0 |
| Ensembl Protein ID |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1739 | DLG1 | 3007 | NP_004078.2 | in vitro | 16637659 |
| 1740 | DLG2 | 4663 | NP_001136171.1 | in vitro | 16637659 |
| 1741 | DLG3 | 2177 | NP_066943.2 | in vitro | 16637659 |
| 5998 | RGS3 | 3720 | NP_652759.3 | in vitro | 16637659 |
| 6640 | SNTA1 | 3009 | NP_003089.1 | in vivo | 11163757 |
| 8573 | CASK | 2164 | NP_003679.2 | in vitro | 16637659 |
| 10207 | INADL | 4434 | NP_733750.2 | in vitro | 16637659 |
| 55824 | PAG1 | 5772 | NP_060910.3 | in vitro | 11163757 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Alanine, aspartate and glutamate metabolism | hsa00250 |
| Arginine biosynthesis | hsa00220 |
| Central carbon metabolism in cancer | hsa05230 |
| D-Glutamine and D-glutamate metabolism | hsa00471 |
| GABAergic synapse | hsa04727 |
| Glutamatergic synapse | hsa04724 |
| Metabolic pathways | hsa01100 |
| MicroRNAs in cancer | hsa05206 |
| Proximal tubule bicarbonate reclamation | hsa04964 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00204 | 490-575 | ANK |
| cl02529 | 490-575 | ANK superfamily |
| pfam04960 | 177-463 | Glutaminase |
| cl00907 | 177-463 | Glutaminase superfamily |
| TIGR03814 | 164-448 | Gln_ase |
| PRK00971 | 164-461 | PRK00971 |
| COG2066 | 164-454 | GlsA |
| PRK12356 | 153-447 | PRK12356 |
| PRK12357 | 177-458 | PRK12357 |
| cd00204 | 490-572 | ANK |
| cd00204 | 514-572 | ANK |
| cd00204 | 490-539 | ANK |
| pfam00023 | 520-551 | Ank |
| smart00248 | 518-541 | ANK |
| pfam13606 | 520-541 | Ank_3 |
| pfam13637 | 520-572 | Ank_4 |
| pfam13637 | 490-539 | Ank_4 |
| pfam12796 | 490-572 | Ank_2 |
| PTZ00322 | 488-575 | PTZ00322 |
| COG0666 | 490-582 | ANKYR |
| pfam12796 | 490-550 | Ank_2 |
| PLN03192 | 439-539 | PLN03192 |
| COG0666 | 483-575 | ANKYR |
| PHA03100 | 479-576 | PHA03100 |
| PLN03192 | 489-572 | PLN03192 |
| pfam13857 | 516-558 | Ank_5 |
| PHA02874 | 508-572 | PHA02874 |
| pfam13857 | 538-585 | Ank_5 |
| COG0666 | 490-573 | ANKYR |
Ontology Information
| HPRD ID | 17154 |
|---|---|
| Molecular Class | Enzyme: Hydrolase |
| Molecular Function | Transporter activity (GO:0005215) |
| Biological Process | Transport (GO:0006810) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q9UI32 | DB00130 | L-Glutamine | SmallMoleculeDrug |