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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PDCD4 | 27250 | programmed cell death 4 (neoplastic transformation inhibitor) | 10 | H731 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17828298 | 2008 | Cell line : HT29 Source : ATCC and human colon tissue array slides were purchased from Imgenex (IMH-306, IMH-339 and IMH-359) and Cybrdi (CC05-02). Sample Type : Human colon tissue array slides No. of Sample : - Stage : - | Plasmids construction, virus production and transduction,qPCR,Immunoprecipitation and immunoblotting,Cell transfection,Matrigel invasion assay and luciferase activity assays. | Down-regulation | - | Reduced Pdcd4 expression promotes invasion appears to involve the activation of beta-catenin/Tcf and AP-1-dependent transcription. |
| 21546206 | 2011 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 48 colorectal tumours, 61 normal tissues and 7 polyps and A subset of 48 specimens (31 tumours and 17 normal tissues) Stage : - | real time RT-PCR, immunohistochemistry | Down-regulation | - | miR-21/PDCD4 axis could represent a novel therapeutic strategy in the treatment of colorectal cancer. |
| 22267128 | 2012 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 326 CRC (Dukes' stage A, 44 cases; Dukes' B, 118 cases; Dukes' C, 100 cases; Dukes' D, 64 cases) Stage : Dukes' stage A, B, C and D. | real time RT-PCR,TaqMan microRNA assay | Down-regulation | - | PDCD4 mRNA levels were negatively regulated by miR-21in each tumor stage of CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010] |
| Chromosome | 10 |
| Location | 10q24 |
| Start | 112631553 |
| End | 112659764 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 28212 |
| OMIM ID | 608610 |
| HGNC ID | HGNC:8763 |
| Unigene ID | Hs.711490 |
| Ensembl ID | ENSG00000150593 |
| PharmGKB ID | PA33113 |
Protein Information
| Protein ID | NP_055271.2 |
|---|---|
| Protein Name | programmed cell death 4 (neoplastic transformation inhibitor) |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 469 |
| Uniprot ID | Q3V6T2 |
| Ensembl Protein ID | ENSP00000263630 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 457 |
| S | Phosphorylation | 446 |
| Y | Phosphorylation | 152;- |
| Y | Phosphorylation | 141;- |
| T | Phosphorylation | 93;- |
| T | Phosphorylation | 82;- |
| S | Phosphorylation | 94;- |
| S | Phosphorylation | 83;- |
| S | Phosphorylation | 76;- |
| S | Phosphorylation | 65;- |
| S | Phosphorylation | 78;- |
| S | Phosphorylation | 67;- |
| S | Phosphorylation | 80;- |
| S | Phosphorylation | 69;- |
| S | Phosphorylation | 71;- |
| S | Phosphorylation | 60;- |
| S | Phosphorylation | 317 |
| S | Phosphorylation | 306 |
| S | Phosphorylation | 313 |
| S | Phosphorylation | 302 |
| S | Phosphorylation | 49 |
| S | Phosphorylation | 38 |
| T | Phosphorylation | 397 |
| T | Phosphorylation | 386 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1981 | EIF4G1 | 6774 | NP_886553.2 | in vitro | 12054647 |
| 6125 | RPL5 | 4699 | NP_000960.2 | in vitro;yeast 2-hybrid | 12054647 |
| 6176 | RPLP1 | 1611 | NP_000994.1 | in vitro | 12054647 |
| 6207 | RPS13 | 1604 | NP_001008.1 | in vitro;yeast 2-hybrid | 12054647 |
| 8945 | BTRC | 4596 | NP_378663.1 | in vivo | 18296647 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| MicroRNAs in cancer | hsa05206 |
| Proteoglycans in cancer | hsa05205 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| smart00544 | 327-440 | MA3 |
| cl02653 | 327-440 | MA3 superfamily |
| smart00544 | 164-275 | MA3 |
| cl02653 | 164-275 | MA3 superfamily |
| pfam02847 | 329-440 | MA3 |
| pfam02847 | 164-275 | MA3 |
Ontology Information
| HPRD ID | 6085 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Transporter activity (GO:0005215) |
| Biological Process | Transport (GO:0006810) |
Drug Information
No matching records could be found.