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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
PDLIM3 27295 PDZ and LIM domain 3  4ALP 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22276141   2012Cell line : -

Source : UAB Hospital

Sample Type : CRC tumor and normal tissues

No. of Sample : 304 Stage III CRC

Stage : TNM Stage III.

Microarray for expression profiling,p53 mutational analysis,Microsatellite instability analysis,qNPA, qRT-PCR, and IHC platforms.Down-regulation--


Gene Details



NC_000004.11 (186421814..186456712, complement)

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Gene Type protein coding
Gene Family -
Description The protein encoded by this gene contains a PDZ domain and a LIM domain, indicating that it may be involved in cytoskeletal assembly. In support of this, the encoded protein has been shown to bind the spectrin-like repeats of alpha-actinin-2 and to colocalize with alpha-actinin-2 at the Z lines of skeletal muscle. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Aberrant alternative splicing of this gene may play a role in myotonic dystrophy. [provided by RefSeq, Apr 2012]  
Chromosome 4
Location 4q35
Start 186421814  
End 186456712  
Strand -  
Gene Sequence

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Length 34899  
OMIM ID 605889   
HGNC ID HGNC:20767   
Unigene ID Hs.701364   
Ensembl ID ENSG00000154553   
PharmGKB ID PA134970631   

mRNA Information


mRNA ID ?NM_001114107.4
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS3844.1



Protein Information


      
Protein IDNP_001107579.1
Protein NamePDZ and LIM domain 3
Molecular Wt. (Da)0
Protein Sequence

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Length 364  
Uniprot IDQ96QK1
Ensembl Protein ID ENSP00000299138  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation361

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd09450294-346  LIM_ALP
cl02475294-346  LIM superfamily
cd00992Feb-80  PDZ_signaling
cl00117Feb-80  PDZ superfamily
cd09360294-345  LIM_ALP_like
cd09448294-345  LIM_CLP36
cd09451294-346  LIM_RIL
smart00228Jan-83  PDZ
pfam00595Apr-80  PDZ
cd09449294-345  LIM_Mystique
cd08368294-345  LIM
pfam00412294-344  LIM
smart00132294-344  LIM
cd09327294-341  LIM1_abLIM
smart00735184-209  ZM
cl00302184-209  ZM superfamily
cd09391294-343  LIM1_Lrg1p_like
cd09361294-344  LIM1_Enigma_like
cd0013614-72  PDZ
cd09336294-343  LIM1_Paxillin_like
cd09352294-342  LIM1_Ajuba_like
cd09406294-342  LIM1_Leupaxin
cd09338294-344  LIM3_Paxillin_like
cd09351294-342  LIM1_LPP
cd09456294-342  LIM2_Enigma
cd09340294-344  LIM1_Testin_like
cd09334292-344  LIM4_PINCH
cd0098820-92  PDZ_CTP_protease
cd09377287-344  LIM2_Lhx2_Lhx9
cd09405293-342  LIM1_Paxillin
cd0098716-54  PDZ_serine_protease
cd09457294-343  LIM2_ENH
cd09410294-344  LIM3_Leupaxin
cd09337294-343  LIM2_Paxillin_like
cd09350294-342  LIM1_TRIP6
cd09443294-345  LIM_Ltd-1
cd09483294-344  LIM1_Prickle_1
cd09332294-333  LIM2_PINCH
cd09462282-344  LIM1_LIMK1
cd09445294-344  LIM_Mical_like_2
cd09409294-344  LIM3_Paxillin
cd09415294-344  LIM1_Prickle
cd09349288-342  LIM1_Zyxin
cd09484294-344  LIM1_Prickle_2
cd09362294-343  LIM2_Enigma_like
cd0098925-86  PDZ_metalloprotease
cd09447294-344  LIM_LASP
cd09841294-344  LIM1_Prickle_3
cd09414294-344  LIM1_LIMPETin
cd09392294-344  LIM2_Lrg1p_like
cd09453294-342  LIM1_ENH
cd09407294-341  LIM2_Paxillin
cd09413310-344  LIM1_Testin
cd09452294-341  LIM1_Enigma
cd09328294-323  LIM2_abLIM
cd09379294-344  LIM2_AWH
cd09439308-344  LIM_Mical
cd09359294-344  LIM_LASP_like
cd09363314-345  LIM3_Enigma_like
pfam1318028-54  PDZ_2
cd09440314-344  LIM1_SF3
cd09397294-344  LIM1_UF1
cd09455294-342  LIM1_Enigma_like_1
cd09331294-342  LIM1_PINCH
cd09330294-338  LIM4_abLIM
cd09372294-341  LIM2_FBLP-1
cd09348294-346  LIM4_FHL1
cd09387294-343  LIM2_LMO4
cd09461306-345  LIM3_Enigma_like_1
cd09358314-344  LIM_Mical_like
cd09467291-342  LIM1_Lhx3b
cd09342294-341  LIM3_Testin_like
cd09429294-341  LIM3_FHL1
cd09412294-343  LIM4_Leupaxin
cd09840294-342  LIM2_CRP2
cd09471294-341  LIM2_Isl2
cd09474294-344  LIM2_Lhx2
cd09432294-341  LIM6_LIMPETin
cd09346294-327  LIM3_FHL
cd09339294-342  LIM4_Paxillin_like
cd09475294-344  LIM2_Lhx9
cd09468294-342  LIM1_Lhx4
cd09374294-341  LIM2_Isl
cd09400290-343  LIM_like_1
cd09486314-344  LIM_Eplin_like_1
cd09465293-341  LIM2_LIMK2
cd09404294-343  LIM1_MLP84B_like
cd09347294-341  LIM4_FHL
cd09396294-340  LIM_DA1
cd09466291-342  LIM1_Lhx3a
PLN0004927-83  PLN00049
TIGR0390019-73  prc_long_Delta
COG026517-54  DegQ
TIGR0022527-70  prc
COG3975Jul-75  COG3975
TIGR0203819-54  protease_degS
PRK1089819-54  PRK10898
TIGR0203720-54  degP_htrA_DO
COG07502-125  RseP


Ontology Information


   
HPRD ID9893
Molecular ClassUnclassified
Molecular FunctionMetallopeptidase activity (GO:0008237)
Biological ProcessProtein metabolism (GO:0019538)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO