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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
GLDC 2731 glycine dehydrogenase (decarboxylating)  9GCSP, NKH 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25117815   2014Cell line : -

Source : Utilised exome-sequencing data on 25 sporadic microsatellite-instable (MSI) colorectal cancers (CRCs)

Sample Type : Exome-sequencing data

No. of Sample : -

Stage : -

-Mutation--


Gene Details



NC_000009.11 (6532464..6645692, complement)

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Gene Type protein coding
Gene Family -
Description Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).[provided by RefSeq, Jan 2010]  
Chromosome 9
Location 9p22
Start 6532464  
End 6645692  
Strand -  
Gene Sequence

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Length 113229  
OMIM ID 238300   
HGNC ID HGNC:4313   
Unigene ID Hs.584238   
Ensembl ID ENSG00000178445   
PharmGKB ID PA28716   

mRNA Information


mRNA ID NM_000170.2
Exon join(1..448,1001..1079,25374..25509,35337..35501, 39024..39101,40415..40562,40909..41105,43488..43584, 50574..50679,52703..52842,53470..53550,56401..56498, 56991..57075,57251..57292,58410..58552,80264..80339, 87009..87134,89391..89540,90912..91024,92184..92325, 94779..94890,105547..105642,109457..109629,110905..110985, 112533..113229)  
mRNA Sequence

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Length 3820  



CDS Information


   
Location 194..3256
CDS Sequence

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CCDS ID CCDS34987.1



Protein Information


      
Protein ID NP_000161.2
Protein Name
Molecular Wt. (Da)1020
Protein Sequence

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Length 0  
Uniprot IDP35268
Ensembl Protein ID ENSP00000346088  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation39
SPhosphorylation38

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
81793TLR105884NP_112218.2yeast 2-hybrid16482509   


Pathway Information


                        
Pathway Name Pathway ID
Carbon metabolism hsa01200
Glycine, serine and threonine metabolism hsa00260
Glyoxylate and dicarboxylate metabolism hsa00630
Metabolic pathways hsa01100


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00613113-488  GDC-P
cl18945113-488  AAT_I superfamily
cd00613531-923  GDC-P
cl18945531-923  AAT_I superfamily
pfam0234765-488  GDC-P
COG1003518-977  GcvP2
COG040357-489  GcvP1
PRK04366530-953  PRK04366
PRK0045172-458  PRK00451
cd01494597-757  AAT_I
COG0403591-747  GcvP1
COG1003163-349  GcvP2
PRK00451817-923  PRK00451
cd06450623-729  DOPA_deC_like
cd06502586-729  TA_like
PRK00451588-747  PRK00451
TIGR03812530-695  tyr_de_CO2_Arch
PRK0536757-1009  PRK05367
PLN0241451-1009  PLN02414
TIGR0046166-1002  gcvP
PRK1256661-1008  PRK12566
pfam01212586-729  Beta_elim_lyase
TIGR00858590-754  bioF
COG0520577-757  CsdA


Ontology Information


   
HPRD ID1609
Molecular ClassEnzyme: Decarboxylase
Molecular FunctionTransferase activity (GO:0016740)
Biological ProcessProtein metabolism (GO:0019538)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P23378DB00145GlycineSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO