Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| GLI1 | 2735 | Glioma-associated oncogene homolog 1 (zinc finger protein) | 12 | GLI |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 16701100 | 2006 | Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 44 Stage : TNM Stage I-III | real time RT-PCR | Up-regulation | - | Increased expression of SHh mRNA in human colonic adenocarcinomas and in a colorectal cell line with downstream increased expression of GLI1 and FOXM1 mRNA known to promote cell proliferation.
|
| 17461467 | 2007 | Cell line : - Source : Shandong Qilu Hospital, Jinan, China. Sample Type : CRC tumor and Normal tissue No. of Sample : 25 Stage : TNM Stage I-III | RT-PCR, in situ hybridization and immunohistochemistry | Up-regulation | - | - |
| 20854074 | 2010 | Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 36 CRCs, 21 hyperplastic polyps and 32 colorectal adenomas Stage : - | RT-PCR and immunohistochemistry | Up-regulation | - | Expressions of SHH and GLI1 proteins were increased significantly in CRCs compared with those in hyperplastic polyps and colorectal adenomas. |
| 22901214 | 2012 | Cell line : - Source : Guangzhou First Municipal People Hospital Affiliated to Guangzhou Medical College. Sample Type : CRC tumor and Normal tissue No. of Sample : 43 CRC patients and 22 normal colorectal tissue Stage : TNM Stage I-IV | RT-PCR and immunohistochemistry | Up-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Zinc fingers, C2H2-type |
| Description | This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009] |
| Chromosome | 12 |
| Location | 12q13.2-q1 |
| Start | 57460135 |
| End | 57472268 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 12134 |
| OMIM ID | 165220 |
| HGNC ID | HGNC:4317 |
| Unigene ID | Hs.632702 |
| Ensembl ID | ENSG00000111087 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001160045.1 |
|---|---|
| Exon | join(1..67,4539..4734,4977..5121,5473..5562,5654..5791, 6106..6255,7199..7363,7860..8090,9297..9564,10183..12134) | mRNA Sequence | Download Select all |
| Length | 3414 |
CDS Information
| Location | join(3558..3657,3865..3957,4539..4734,4977..5121, 5473..5562,5654..5791,6106..6255,7199..7363,7860..8090, 9297..9564,10183..11927) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS8940.1 |
Protein Information
| Protein ID | NP_001153517.1 |
|---|---|
| Protein Name | Glioma-associated oncogene homolog 1 (zinc finger protein) |
| Molecular Wt. (Da) | 104497 |
| Protein Sequence | Download Select all |
| Length | 978 |
| Uniprot ID | Q12982 |
| Ensembl Protein ID | ENSP00000412767 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1859 | DYRK1A | 9018 | NP_001387.2 | in vitro;in vivo | 12138125 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Basal cell carcinoma | hsa05217 |
| cAMP signaling pathway | hsa04024 |
| Hedgehog signaling pathway | hsa04340 |
| Pathways in cancer | hsa05200 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam13465 | 317-344 | zf-H2C2_2 |
| cl22375 | 317-344 | zf-H2C2_2 superfamily |
| pfam13465 | 287-314 | zf-H2C2_2 |
| cl22375 | 287-314 | zf-H2C2_2 superfamily |
| PHA03247 | 562-1081 | PHA03247 |
| COG5189 | 297-387 | SFP1 |
| PRK10263 | 725-877 | PRK10263 |
| PHA03247 | 511-870 | PHA03247 |
| COG5048 | 299-379 | COG5048 |
| COG5048 | 291-347 | COG5048 |
| PRK14086 | 763-983 | dnaA |
| PHA03247 | 562-1039 | PHA03247 |
| pfam09770 | 756-946 | PAT1 |
| PRK12323 | 520-652 | PRK12323 |
| COG5048 | 275-382 | COG5048 |
| COG5236 | 196-433 | COG5236 |
| pfam09770 | 642-909 | PAT1 |
| COG5048 | 228-364 | COG5048 |
| PRK03427 | 807-929 | PRK03427 |
Ontology Information
| HPRD ID | 4481 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | GTPase activator activity (GO:0005096) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.