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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
MAT2B 27430 methionine adenosyltransferase II, beta  5MATIIbeta, SDR23E1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
23325601   2013Cell line : HepG2, Huh7 , RKO

Source : Cell Culture core facility at the University of Southern California Research Center for Liver Diseases. Giordano (Whipps Cross University Hospital, London, UK)

Sample Type : CRC tumor and normal tissue

No. of Sample : 16

Stage : -

Coimmunoprecipitation, immunohistochemistry and western blotting, pull-down assaysUp-regulation-MAT2B and GIT1 form a scaffold, which recruits and activates MEK and ERK to promote growth and tumorigenesis. This novel MAT2B/GIT1 complex may provide a potential therapeutic gateway in human liver and colon cancer


Gene Details



NC_000005.9 (162930070..162946359)

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Gene Type protein coding
Gene Family Short chain dehydrogenase/reductase superfamily / Extended SDR fold
Description The protein encoded by this gene belongs to the methionine adenosyltransferase (MAT) family. MAT catalyzes the biosynthesis of S-adenosylmethionine from methionine and ATP. This protein is the regulatory beta subunit of MAT. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]  
Chromosome 5
Location 5q34-q35
Start 162930070  
End 162946359  
Strand +  
Gene Sequence

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Length 16290  
OMIM ID 605527   
HGNC ID HGNC:6905   
Unigene ID Hs.54642   
Ensembl ID ENSG00000038274   
PharmGKB ID PA30648   

mRNA Information


mRNA ID ?NM_013283.4
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS4364.1



Protein Information


      
Protein IDNP_037415.1
Protein Namemethionine adenosyltransferase II, beta
Molecular Wt. (Da)0
Protein Sequence

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Length 334  
Uniprot IDQ96KP4
Ensembl Protein ID ENSP00000325548  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation282
SPhosphorylation271

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
4144MAT2A3275NP_005902.1in vivo12671891   


Pathway Information


                  
Pathway Name Pathway ID
Biosynthesis of amino acids hsa01230
Cysteine and methionine metabolism hsa00270
Metabolic pathways hsa01100


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0525430-316  dTDP_HR_like_SDR_e
cl2145430-316  NADB_Rossmann superfamily
cd0523230-318  UDP_G4E_4_SDR_e
cd0894631-228  SDR_e
cd0522631-189  SDR_e_a
cd0524130-263  3b-HSD-like_SDR_e
cd0522831-319  AR_FR_like_1_SDR_e
cd0526529-270  SDR_a1
cd0524629-317  dTDP_GD_SDR_e
cd0525829-188  CDP_TE_SDR_e
cd0526331-188  MupV_like_SDR_e
cd0524831-230  ADP_GME_SDR_e
cd0525330-167  UDP_GE_SDE_e
cd0527130-261  NDUFA9_like_SDR_a
cd0981330-188  3b-HSD-NSDHL-like_SDR_e
cd0526430-193  UDP_G4E_5_SDR_e
cd0523728-171  UDP_invert_4-6DH_SDR_e
cd0524730-181  UDP_G4E_1_SDR_e
cd0895730-319  WbmH_like_SDR_e
cd0523830-167  Gne_like_SDR_e
cd0523930-95  GDP_FS_SDR_e
cd0523530-187  SDR_e1
cd0524031-170  UDP_G4E_3_SDR_e
cd0525630-228  UDP_AE_SDR_e
cd0525228-151  CDP_GD_SDR_e
cd0526631-295  SDR_a4
cd0524330-181  SDR_a5
cd0527230-167  TDH_SDR_e
cd0981132-188  3b-HSD_HSDB1_like_SDR_e
cd0523629-168  FAR-N_SDR_e
cd0526030-167  GDP_MD_SDR_e
cd0893231-108  HetN_like_SDR_c
cd0525029-237  CC3_like_SDR_a
cd0533429-76  DHPR_SDR_c_like
cd0523331-125  SDR_c
pfam0107332-248  3Beta_HSD
cd0534631-64  SDR_c5
pfam0432131-323  RmlD_sub_bind
COG109130-305  RfbD
TIGR0121430-319  rmlD
COG045130-323  WcaG
pfam0137031-237  Epimerase
PRK0998774-301  PRK09987
COG108730-169  GalE
TIGR0117930-181  galE
COG108625-168  FlaA1
pfam0271931-171  Polysacc_synt_2
TIGR0118130-328  dTDP_gluc_dehyt
pfam1346031-236  NAD_binding_10
PRK1021729-170  PRK10217
COG070229-192  YbjT
COG108829-163  RfbB
PRK0586530-136  PRK05865
TIGR0219731-164  heptose_epim
TIGR0358928-189  PseB
TIGR0346630-172  HpnA
PRK0757727-67  PRK07577
pfam0799333-188  NAD_binding_4
pfam0010631-136  adh_short
PRK1008430-156  PRK10084
COG422125-63  YdfG
TIGR0177731-96  yfcH
COG102828-136  FabG


Ontology Information


   
HPRD ID6411
Molecular ClassEnzyme: Adenosyltransferase
Molecular FunctionATPase activity (GO:0016887)
Biological ProcessMetabolism (GO:0008152); Energy pathways (GO:0006091)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
Q9NZL9DB00134L-MethionineSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO