Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| GNA11 | 2767 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) | 19 | FBH, FBH2, FHH2 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20454457 | 2010 | Cell line : RKO, HCT116, SW480, SW837, Colo205, CaCo2 and DLD1b,CCD841 Source : ATCC Sample Type : - No. of Sample : - Stage : - | Chromatin immunoprecipitation,CGI microarray,ChIP-Chop analysis,MassARRAY analysis . | Methylation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene belongs to the family of guanine nucleotide-binding proteins (G proteins), which function as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes one of the alpha subunits (subunit alpha-11). Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2). Patients with HHC2 and HYPOC2 exhibit decreased or increased sensitivity, respectively, to changes in extracellular calcium concentrations. [provided by RefSeq, Dec 2013] |
| Chromosome | 19 |
| Location | 19p13.3 |
| Start | 3094408 |
| End | 3121468 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 27061 |
| OMIM ID | 139313 |
| HGNC ID | HGNC:4379 |
| Unigene ID | Hs.650575 |
| Ensembl ID | ENSG00000088256 |
| PharmGKB ID | PA28764 |
mRNA Information
| mRNA ID | NM_002067.4 |
|---|---|
| Exon | join(1..378,15740..15924,18921..19075,20535..20663, 24515..24644,24797..24950,26580..29593) | mRNA Sequence | Download Select all |
| Length | 4145 |
Protein Information
| Protein ID | NP_002058.2 |
|---|---|
| Protein Name | 41992 |
| Molecular Wt. (Da) | 359 |
| Protein Sequence | Download Select all |
| Length | 0 |
| Uniprot ID | Q15418 |
| Ensembl Protein ID | ENSP00000363283 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| C | Palmitoylation | 10 |
| C | Palmitoylation | 9 |
| T | Phosphorylation | 162 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 147 | ADRA1B | 80 | NP_000670.1 | in vivo | 9481484 |
| 154 | ADRB2 | 187 | NP_000015.1 | in vivo | 7797501 |
| 624 | BDKRB2 | 213 | NP_000614.1 | in vitro;in vivo | 12130679 |
| 1129 | CHRM2 | 328 | NP_000730.1 | in vivo | 7797501 |
| 1909 | EDNRA | 571 | NP_001948.1 | in vitro | 10789830 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Aldosterone synthesis and secretion | hsa04925 |
| Amoebiasis | hsa05146 |
| Calcium signaling pathway | hsa04020 |
| cGMP-PKG signaling pathway | hsa04022 |
| Chagas disease (American trypanosomiasis) | hsa05142 |
| Cholinergic synapse | hsa04725 |
| Gap junction | hsa04540 |
| GnRH signaling pathway | hsa04912 |
| Insulin secretion | hsa04911 |
| Long-term depression | hsa04730 |
| Pathways in cancer | hsa05200 |
| Vascular smooth muscle contraction | hsa04270 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00066 | 40-353 | G-alpha |
| cl21455 | 40-353 | P-loop_NTPase superfamily |
| cd00878 | 184-281 | Arf_Arl |
| pfam00025 | 184-282 | Arf |
| cd04156 | 184-278 | ARLTS1 |
| PLN00223 | 184-278 | PLN00223 |
| PTZ00133 | 184-278 | PTZ00133 |
| cd04150 | 184-278 | Arf1_5_like |
| cd04149 | 184-278 | Arf6 |
| smart00177 | 184-278 | ARF |
| cd00879 | 159-278 | Sar1 |
| cd04151 | 184-278 | Arl1 |
| cd04160 | 184-278 | Arfrp1 |
| cd04161 | 185-278 | Arl2l1_Arl13_like |
| cd04158 | 176-278 | ARD1 |
| cd04155 | 185-280 | Arl3 |
| cd04157 | 184-278 | Arl6 |
| cd04154 | 185-278 | Arl2 |
| cd04153 | 185-278 | Arl5_Arl8 |
| smart00275 | 19-357 | G_alpha |
| pfam00503 | 38-348 | G-alpha |
Ontology Information
| HPRD ID | 3403 |
|---|---|
| Molecular Class | G protein |
| Molecular Function | Protein serine/threonine kinase activity (GO:0004674) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.