Search results:


General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
GNAI1 2770 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1  7- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21978696   2011Cell line : HT 29

Source : -

Sample Type : -

No. of Sample : -

Stage : -

MTT assay,immunohistochemistry,scanning electron microscopy,real time RT-PCRUp-regulation--


Gene Details



NC_000007.13 (79764140..79848725)

View Larger Image
   
Gene Type protein coding
Gene Family -
Description Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The alpha subunit binds guanine nucleotide, can hydrolyze GTP, and can interact with other proteins. The protein encoded by this gene represents the alpha subunit of an inhibitory complex. The encoded protein is part of a complex that responds to beta-adrenergic signals by inhibiting adenylate cyclase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]  
Chromosome 7
Location 7q21-q22
Start 79764140  
End 79848725  
Strand +  
Gene Sequence

   Download   Select all

Length 84586  
OMIM ID 139310   
HGNC ID HGNC:4384   
Unigene ID Hs.134587   
Ensembl ID ENSG00000127955   
PharmGKB ID PA172   

mRNA Information


mRNA ID NM_002069.5
Exon join(1..455,54128..54170,54267..54408,64402..64559, 68881..69009,76146..76275,77893..78046,82480..84586)  
mRNA Sequence

   Download   Select all

Length 3318  



CDS Information


   
Location 338..1402
CDS Sequence

   Download   Select all

CCDS ID CCDS5595.1



Protein Information


      
Protein IDNP_002060.4
Protein Name1..354
Molecular Wt. (Da)354
Protein Sequence

   Download   Select all

Length 0  
Uniprot IDP23443
Ensembl Protein ID ENSP00000225577  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                         
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
150ADRA2A78NP_000672.3in vitro11732925   
1268CNR1259NP_057167.2in vivo11168387   
1814DRD3540NP_000787.2in vivo10978845   
2057EPOR587NP_000112.1in vivo12538595   
4926NUMA11236CAA77669.1in vitro;in vivo15537540   
8936WASF15434NP_003922.1in vitro16530190   
29899GPSM26609NP_037428.3in vitro;in vivo15537540   


Pathway Information


                                                                                                                                                                                                            
Pathway Name Pathway ID
Adrenergic signaling in cardiomyocytes hsa04261
Alcoholism hsa05034
Axon guidance hsa04360
cAMP signaling pathway hsa04024
cGMP-PKG signaling pathway hsa04022
Chagas disease (American trypanosomiasis) hsa05142
Chemokine signaling pathway hsa04062
Cholinergic synapse hsa04725
Circadian entrainment hsa04713
Cocaine addiction hsa05030
Dopaminergic synapse hsa04728
Estrogen signaling pathway hsa04915
GABAergic synapse hsa04727
Gap junction hsa04540
Gastric acid secretion hsa04971
Glutamatergic synapse hsa04724
Leukocyte transendothelial migration hsa04670
Long-term depression hsa04730
Melanogenesis hsa04916
Morphine addiction hsa05032
Oxytocin signaling pathway hsa04921
Parkinson's disease hsa05012
Pathways in cancer hsa05200
Pertussis hsa05133
Platelet activation hsa04611
Progesterone-mediated oocyte maturation hsa04914
Rap1 signaling pathway hsa04015
Regulation of lipolysis in adipocytes hsa04923
Renin secretion hsa04924
Retrograde endocannabinoid signaling hsa04723
Serotonergic synapse hsa04726
Sphingolipid signaling pathway hsa04071
Tight junction hsa04530
Toxoplasmosis hsa05145


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0006634-348  G-alpha
cl2145534-348  P-loop_NTPase superfamily
cd00878185-273  Arf_Arl
pfam00025185-273  Arf
cd04149177-273  Arf6
smart00177177-273  ARF
PLN00223177-273  PLN00223
cd04150177-273  Arf1_5_like
PTZ00133177-273  PTZ00133
cd04151177-273  Arl1
cd04156173-273  ARLTS1
cd04153189-273  Arl5_Arl8
cd04154189-273  Arl2
cd00879154-273  Sar1
cd04157179-286  Arl6
cd04155193-273  Arl3
cd04159197-273  Arl10_like
cd04158171-273  ARD1
cd04160194-273  Arfrp1
cd00882177-310  Ras_like_GTPase
cd04161181-273  Arl2l1_Arl13_like
smart0027514-352  G_alpha
pfam0050332-343  G-alpha
smart00178160-272  SAR
TIGR00231196-281  small_GTP


Ontology Information


   
HPRD ID10203
Molecular ClassG protein
Molecular FunctionProtein serine/threonine kinase activity (GO:0004674)
Biological ProcessProtein metabolism (GO:0019538); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO