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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| GPD1 | 2819 | glycerol-3-phosphate dehydrogenase 1 (soluble) | 12 | - |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19425502 | 2009 | Cell line : - Source : - Sample Type : Tumors and adjacent normal tissues No. of Sample : - Stage : - | 2-D PAGE and MALDI-TOF mass-spectrometry | Up-regulation | - | Overexpression of GPD1 and RRBP1 proteins and lack of expression for HNRNPH1 and SERPINB6 proteins which are new candidate biomarkers of colon cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encoded protein plays a critical role in carbohydrate and lipid metabolism by catalyzing the reversible conversion of dihydroxyacetone phosphate (DHAP) and reduced nicotine adenine dinucleotide (NADH) to glycerol-3-phosphate (G3P) and NAD+. The encoded cytosolic protein and mitochondrial glycerol-3-phosphate dehydrogenase also form a glycerol phosphate shuttle that facilitates the transfer of reducing equivalents from the cytosol to mitochondria. Mutations in this gene are a cause of transient infantile hypertriglyceridemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012] |
| Chromosome | 12 |
| Location | 12q13.12 |
| Start | 50497602 |
| End | 50505103 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 7502 |
| OMIM ID | 138420 |
| HGNC ID | HGNC:4455 |
| Unigene ID | Hs.524418 |
| Ensembl ID | ENSG00000167588 |
| PharmGKB ID | PA28836 |
mRNA Information
| mRNA ID | NM_005276.3 |
|---|---|
| Exon | join(1..273,756..933,1730..1870,2470..2608,2987..3099, 3749..3982,4206..4312,5605..7502) | mRNA Sequence | Download Select all |
| Length | 3083 |
Protein Information
| Protein ID | NP_005267.2 |
|---|---|
| Protein Name | 37437 |
| Molecular Wt. (Da) | 349 |
| Protein Sequence | Download Select all |
| Length | 0 |
| Uniprot ID | P39019 |
| Ensembl Protein ID | ENSP00000470004 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 5764 | PTN | 1199 | NP_002816.1 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Glycerophospholipid metabolism | hsa00564 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam07479 | 192-342 | NAD_Gly3P_dh_C |
| cl08454 | 192-342 | NAD_Gly3P_dh_C superfamily |
| pfam01210 | 5-172 | NAD_Gly3P_dh_N |
| cl21454 | 5-172 | NADB_Rossmann superfamily |
| TIGR03376 | 5-342 | glycerol3P_DH |
| PTZ00345 | 1-344 | PTZ00345 |
| COG0240 | 4-343 | GpsA |
| PRK00094 | 4-342 | gpsA |
| PRK12439 | 5-287 | PRK12439 |
| PRK14618 | 2-347 | PRK14618 |
| PRK14620 | 5-339 | PRK14620 |
| PRK14619 | 1-316 | PRK14619 |
Ontology Information
| HPRD ID | 11796 |
|---|---|
| Molecular Class | Enzyme: Dehydrogenase |
| Molecular Function | Transmembrane receptor activity (GO:0004888) |
| Biological Process | Transport (GO:0006810) |
Drug Information
No matching records could be found.