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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ANG | 283 | angiogenin, ribonuclease, RNase A family, 5 | 14 | RNASE5 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25759532 | 2015 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Western blotting | Up-regulation | - | Increased expression of Ang-1, Ang-2, Tie-2, and VEGF in ulcerative colitis-derived colorectal cancer might lead to chronic colitis and pathologic angiogenesis in rats. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Ribonucleases, RNase A |
| Description | The protein encoded by this gene is an exceedingly potent mediator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. In addition, the mature peptide has antimicrobial activity against some bacteria and fungi, including S. pneumoniae and C. albicans. Alternative splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes ribonuclease, RNase A family, 4 share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq, Aug 2014] |
| Chromosome | 14 |
| Location | 14q11.1-q1 |
| Start | 21152336 |
| End | 21162345 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 10010 |
| OMIM ID | 105850 |
| HGNC ID | HGNC:483 |
| Unigene ID | Hs.283749 |
| Ensembl ID | ENSG00000214274 |
| PharmGKB ID | PA24790 |
mRNA Information
| mRNA ID | NM_001145.4 |
|---|---|
| Exon | join(1..582,9371..10010) | mRNA Sequence | Download Select all |
| Length | 1222 |
Protein Information
| Protein ID | NP_001136.1 |
|---|---|
| Protein Name | angiogenin, ribonuclease, RNase A family, 5 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 147 |
| Uniprot ID | P33992 |
| Ensembl Protein ID | ENSP00000216122 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| C | Disulfide Bridge | 50;105 |
| C | Disulfide Bridge | 63;116 |
| C | Disulfide Bridge | 81;131 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 70 | ACTC1 | 15 | NP_005150.1 | in vitro;in vivo;yeast 2-hybrid | 8127865 |
| 88 | ACTN2 | 19 | NP_001094.1 | in vitro;in vivo;yeast 2-hybrid | 15737636 |
| 537 | ATP6AP1 | 2184 | NP_001174.2 | yeast 2-hybrid | 16169070 |
| 5728 | PTEN | 3431 | NP_000305.3 | yeast 2-hybrid | 16169070 |
| 6997 | TDGF1 | 1757 | NP_003203.1 | yeast 2-hybrid | 16169070 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd06265 | 28-141 | RNase_A_canonical |
| cl00128 | 28-141 | RNase_A superfamily |
| smart00092 | 26-143 | RNAse_Pc |
| cd00163 | 28-140 | RNase_A |
| pfam00074 | 26-140 | RnaseA |
Ontology Information
| HPRD ID | 1154 |
|---|---|
| Molecular Class | Ribonuclease |
| Molecular Function | Helicase activity (GO:0004386) |
| Biological Process | DNA replication (GO:0006260) |
Drug Information
No matching records could be found.