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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CXCR3 | 2833 | chemokine (C-X-C motif) receptor 3 | X | GPR9; MigR; CD182; CD183; Mig-R; CKR-L2; CMKAR3; IP10-R |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17297455 | 2007 | Cell line : Colo205, WiDr, DLD 1, SW480, LS174T, HCT15 , HCT116, HT29, RKO Caco2 Source : Cell Resource Center for Biomedical Research, Tohoku University and ATCC. Sample Type : - No. of Sample : - Stage : - | Immunohistochemistry, immunofluorescence microscopy | Up-regulation | - | Activation of CXCR3 with its ligands stimulates colon cancer metastasis preferentially to the draining lymph nodes with poorer prognosis. |
| 22401929 | 2012 | Cell line : - Source : - Sample Type : CRC tumor No. of Sample : 112 Stage : TNM Stage I-IV | Univariate and multivariate analysis | Up-regulation | - | CXCR3 is an indicator of a poor prognosis and a promising target for cancer therapy in colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Chemokine (C-X-C motif) receptors |
| Description | This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011] |
| Chromosome | X |
| Location | Xq13 |
| Start | 70835766 |
| End | 70838367 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 2602 |
| OMIM ID | 300574 |
| HGNC ID | HGNC:4540 |
| Unigene ID | - |
| Ensembl ID | ENSG00000186810 |
| PharmGKB ID | - |
Protein Information
| Protein ID | |
|---|---|
| Protein Name | chemokine (C-X-C motif) receptor 3 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 0 |
| Uniprot ID | Q9P2E9 |
| Ensembl Protein ID | ENSP00000354045 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3627 | CXCL10 | 930 | NP_001556.2 | in vitro;in vivo | 1 257 123 410 233 760 |
| 5196 | PF4 | 1426 | NP_002610.1 | in vitro | 12782716 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Chemokine signaling pathway | hsa04062 |
| Cytokine-cytokine receptor interaction | hsa04060 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00001 | 76-318 | 7tm_1 |
| PHA03087 | 74-329 | PHA03087 |
| PHA02834 | 74-327 | PHA02834 |
| PHA02638 | 73-336 | PHA02638 |
| PHA03235 | 78-329 | PHA03235 |
| PHA03234 | 77-330 | PHA03234 |
Ontology Information
| HPRD ID | 3733 |
|---|---|
| Molecular Class | Not Available |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.