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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
LAMA1 284217 laminin, alpha 1  18- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21298349   2011Cell line : -

Source : Samsung Medical Center (Seoul, Korea)

Sample Type : CRC tumor and normal tissue

No. of Sample : 22

Stage : Stage I-IV.

Microarray,pyrosequencing Hypermethylation-CpG sites that were hypermethylated (ADHFE1, BOLL, SLC6A15, ADAMTS5, TFPI2, EYA4, NPY, TWIST1, LAMA1, GAS7) in CRC compared to the normal mucosa in the array.

25257191   2015Cell line : -

Source : Koreans patients

Sample Type : Methacarn-fixed tumor

No. of Sample : 88 GC , 139 CRC

Stage : TNM Stage I-IV

SSCP,Immunohistochemistry.Mutation- Frameshift mutations of LAMA1, LAMA3, LAMB1 and LAMB4, and loss of LAMB4 may be features of GC and CRC with MSI-H.


Gene Details



NC_000018.9 (6941743..7117813, complement)

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Gene Type protein coding
Gene Family Laminins
Description This gene encodes one of the alpha 1 subunits of laminin. The laminins are a family of extracellular matrix glycoproteins that have a heterotrimeric structure consisting of an alpha, beta and gamma chain. These proteins make up a major component of the basement membrane and have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Mutations in this gene may be associated with Poretti-Boltshauser syndrome. [provided by RefSeq, Sep 2014]  
Chromosome 18
Location 18p11.3
Start 6941743  
End 7117813  
Strand -  
Gene Sequence

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Length 176071  
OMIM ID 150320   
HGNC ID HGNC:6481   
Unigene ID Hs.270364   
Ensembl ID ENSG00000101680   
PharmGKB ID PA30270   

mRNA Information


mRNA ID ?NM_005559.3
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS32787.1



Protein Information


      
Protein IDNP_005550.2
Protein Namelaminin, alpha 1
Molecular Wt. (Da)0
Protein Sequence

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Length 3075  
Uniprot IDA6NDB9
Ensembl Protein ID ENSP00000344996  



Post-translational Modification Information (Source : HPRD)


Residue Type site
TPhosphorylation351;-
TPhosphorylation2039
SPhosphorylation2040
SPhosphorylation2042

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                   
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
43ACHE10NP_056646.1in vitro12524166   
325APCS101NP_001630.1in vitro8999915   
351APP100NP_000475.1in vitro9136074   
718C3400NP_000055.2in vitro3488995   
1294COL7A1358NP_000085.1in vitro9169408   
1605DAG1546NP_004384.3in vitro;in vivo11   798   066   792   594   100   000   000   
2199FBLN2630NP_001004019.1in vitro;in vivo900   692   210   934   193   
3339HSPG2804NP_005520.4in vitro9688542   
3688ITGB1628NP_391987.1in vitro9688542   
4811NID1574NP_002499.2in vitro8995276   
4907NT5E552NP_002517.1in vivo10470109   
6288SAA197NP_000322.2in vitro8995276   
6289SAA298NP_110381.2in vitro8995276   


Pathway Information


                                          
Pathway Name Pathway ID
Amoebiasis hsa05146
ECM-receptor interaction hsa04512
Focal adhesion hsa04510
Pathways in cancer hsa05200
PI3K-Akt signaling pathway hsa04151
Small cell lung cancer hsa05222
Toxoplasmosis hsa05145


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd001102307-2463  LamG
cl228612307-2463  LamG superfamily
cd001102892-3043  LamG
cl228612892-3043  LamG superfamily
cd001102731-2867  LamG
cl228612731-2867  LamG superfamily
cd001102129-2278  LamG
cl228612129-2278  LamG superfamily
cd001102488-2653  LamG
cl228612488-2653  LamG superfamily
cd00055901-949  EGF_Lam
cl22875901-949  EGF_Lam superfamily
cd000551509-1546  EGF_Lam
cl228751509-1546  EGF_Lam superfamily
cd00055848-900  EGF_Lam
cl22875848-900  EGF_Lam superfamily
cd00055997-1042  EGF_Lam
cl22875997-1042  EGF_Lam superfamily
cd000551043-1086  EGF_Lam
cl228751043-1086  EGF_Lam superfamily
cd00055396-450  EGF_Lam
cl22875396-450  EGF_Lam superfamily
cd00055741-789  EGF_Lam
cl22875741-789  EGF_Lam superfamily
cd00055950-996  EGF_Lam
cl22875950-996  EGF_Lam superfamily
cd00055453-500  EGF_Lam
cl22875453-500  EGF_Lam superfamily
cd000551089-1147  EGF_Lam
cl228751089-1147  EGF_Lam superfamily
cd000551402-1440  EGF_Lam
cl228751402-1440  EGF_Lam superfamily
cd00055270-317  EGF_Lam
cl22875270-317  EGF_Lam superfamily
cd00055790-844  EGF_Lam
cl22875790-844  EGF_Lam superfamily
cd000551452-1507  EGF_Lam
cl228751452-1507  EGF_Lam superfamily
pfam0005522-268  Laminin_N
cl0280622-268  Laminin_N superfamily
smart0013616-268  LamNT
pfam000521218-1360  Laminin_B
cl025481218-1360  Laminin_B superfamily
pfam060092011-2145  Laminin_II
cl055152011-2145  Laminin_II superfamily
pfam00052568-707  Laminin_B
cl02548568-707  Laminin_B superfamily
smart002811213-1344  LamB
pfam000542743-2872  Laminin_G_1
smart00281563-695  LamB
smart002822328-2465  LamG
pfam000542920-3050  Laminin_G_1
smart002822738-2869  LamG
smart002822141-2280  LamG
smart002822915-3043  LamG
pfam000542146-2283  Laminin_G_1
pfam000542514-2658  Laminin_G_1
pfam022102333-2463  Laminin_G_2
pfam000542333-2465  Laminin_G_1
pfam022102920-3043  Laminin_G_2
smart002822512-2653  LamG
pfam022102146-2280  Laminin_G_2
pfam022102743-2869  Laminin_G_2
pfam022102514-2653  Laminin_G_2
pfam00053902-948  Laminin_EGF
smart00180902-948  EGF_Lam
pfam00053454-500  Laminin_EGF
pfam000531044-1092  Laminin_EGF
pfam000531090-1147  Laminin_EGF
pfam000531509-1556  Laminin_EGF
pfam00053951-998  Laminin_EGF
smart00180951-995  EGF_Lam
pfam00053397-456  Laminin_EGF
pfam000531403-1449  Laminin_EGF
pfam00053998-1041  Laminin_EGF
pfam00053849-902  Laminin_EGF
smart001801509-1546  EGF_Lam
smart00180998-1041  EGF_Lam
smart00180397-451  EGF_Lam
smart001801044-1087  EGF_Lam
smart00180454-500  EGF_Lam
smart001801090-1147  EGF_Lam
pfam00053742-788  Laminin_EGF
pfam00053791-846  Laminin_EGF
pfam000531452-1506  Laminin_EGF
smart00180849-892  EGF_Lam
smart001801403-1441  EGF_Lam
smart00180742-783  EGF_Lam
smart007211609-1841  BAR
cl120131609-1841  BAR superfamily
smart00180791-839  EGF_Lam
pfam133852894-3024  Laminin_G_3
smart00180289-313  EGF_Lam
pfam00053270-316  Laminin_EGF
cd13406872-957  TNFRSF4
cl22855872-957  TNFRSF superfamily
cd13406979-1052  TNFRSF4
cl22855979-1052  TNFRSF superfamily
pfam0075481-153  F5_F8_type_C
cl1906781-153  FA58C superfamily
pfam12785868-985  VESA1_N
cl20469868-985  VESA1_N superfamily
cd001761758-1922  SPEC
cl024881758-1922  SPEC superfamily
pfam060081567-1831  Laminin_I
TIGR021681591-2122  SMC_prok_B
COG11961591-2138  Smc
pfam054831610-2135  SCP-1
COG11961591-2125  Smc
TIGR021681591-1920  SMC_prok_B
PRK047781593-1842  PRK04778
pfam061601593-1885  EzrA
COG04191640-2111  SbcC
pfam024631599-2125  SMC_N
TIGR021681598-2016  SMC_prok_B
pfam054831594-1935  SCP-1
COG11961603-1921  Smc
COG11961595-2136  Smc
TIGR021691607-2114  SMC_prok_A
COG15791602-1797  COG1579
pfam03302706-1018  VSP
pfam015761591-2108  Myosin_tail_1
COG04191590-2117  SbcC
TIGR021681652-1985  SMC_prok_B
PTZ004401564-1828  PTZ00440
pfam015761594-2129  Myosin_tail_1
pfam03302720-1047  VSP
pfam055571591-1895  MAD
TIGR045231589-1762  Mplasa_alph_rch
COG11961591-1777  Smc
COG11961720-1986  Smc
TIGR045231591-1995  Mplasa_alph_rch
COG11961703-2014  Smc
TIGR045231592-1808  Mplasa_alph_rch
COG04971585-1841  RecN
PRK039181595-2131  PRK03918
COG04191591-2129  SbcC
pfam122971530-1842  EVC2_like
COG44771596-1993  EzrA
pfam03302816-1112  VSP
COG08401608-2052  Tar
TIGR021691589-1855  SMC_prok_A
pfam156191702-1835  Lebercilin
pfam057011593-1835  WEMBL


Ontology Information


   
HPRD ID19558
Molecular ClassExtracellular matrix protein
Molecular FunctionNucleotide binding (GO:0000166)
Biological ProcessBiological_process unknown (GO:0000004)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO