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General Information
- Evidence
- Gene
- mRNA
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- Protein
- PTM
- Enzyme
- PPi
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26137091 | 2015 | Cell line : - Source : Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology (Warsaw, Poland) Sample Type : CRC tumor and normal tissue No. of Sample : 26 cancer patients, with 15 samples of corresponding normal colonic (NC) mucosa sections, and 42 colorectal adenoma samples Stage : - | Assessment of gene expression levels | Down-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Cadherins / Major cadherins |
| Description | This gene is one of three related type II cadherin genes situated in a cluster on chromosome 18. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein containing five extracellular cadherin repeats. Loss of cadherins may be associated with cancer formation. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Aug 2012] |
| Chromosome | 18 |
| Location | 18q22.1 |
| Start | 64168320 |
| End | 64271375 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 103056 |
| OMIM ID | 603016 |
| HGNC ID | HGNC:1758 |
| Unigene ID | Hs.42771 |
| Ensembl ID | ENSG00000071991 |
| PharmGKB ID | PA26292 |
Protein Information
| Protein ID | NP_001257957.1 |
|---|---|
| Protein Name | cadherin 19, type 2 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 772 |
| Uniprot ID | Q7L7V1 |
| Ensembl Protein ID | ENSP00000284690 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1004 | CDH6 | 4305 | NP_004923.1 | in vivo | 10861224 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd11304 | 152-252 | Cadherin_repeat |
| cl15786 | 152-252 | CA_like superfamily |
| cd11304 | 375-466 | Cadherin_repeat |
| cl15786 | 375-466 | CA_like superfamily |
| cd11304 | 261-366 | Cadherin_repeat |
| cl15786 | 261-366 | CA_like superfamily |
| cd11304 | 49-144 | Cadherin_repeat |
| cl15786 | 49-144 | CA_like superfamily |
| cd11304 | 474-572 | Cadherin_repeat |
| cl15786 | 474-572 | CA_like superfamily |
| pfam01049 | 619-766 | Cadherin_C |
| cl03079 | 619-766 | Cadherin_C superfamily |
| smart00112 | 171-254 | CA |
| pfam00028 | 153-246 | Cadherin |
| smart00112 | 68-146 | CA |
| smart00112 | 393-468 | CA |
| pfam00028 | 375-461 | Cadherin |
| pfam00028 | 49-121 | Cadherin |
| pfam00028 | 261-362 | Cadherin |
| pfam00028 | 474-571 | Cadherin |
| smart00112 | 280-368 | CA |
| cd00031 | 52-144 | CA_like |
| smart00112 | 492-575 | CA |
Ontology Information
| HPRD ID | 18305 |
|---|---|
| Molecular Class | Adhesion molecule |
| Molecular Function | Ubiquitin-specific protease activity (GO:0004843) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.