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General Information
- Evidence
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22539391 | 2012 | Cell line : - Source : Third Affiliated Hospital of Nanjing University of TCM Sample Type : CRC tumor and normal tissues No. of Sample : 146 Stage : - | Tissue microarray by immunohistochemistry | Up-regulation | - | The expressions of JAG1 and DLL1 are related to tumor differentiation and tumor location. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication. [provided by RefSeq, Jul 2008] |
| Chromosome | 6 |
| Location | 6q13-q22.3 |
| Start | 170591288 |
| End | 170599815 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 8528 |
| OMIM ID | 606582 |
| HGNC ID | HGNC:2908 |
| Unigene ID | Hs.379912 |
| Ensembl ID | ENSG00000198719 |
| PharmGKB ID | PA27364 |
Protein Information
| Protein ID | NP_005609.3 |
|---|---|
| Protein Name | delta-like 1 (Drosophila) |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 723 |
| Uniprot ID | Q9Y4C1 |
| Ensembl Protein ID | ENSP00000323659 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 4851 | NOTCH1 | 1827 | NP_060087.3 | in vitro;in vivo | 11006133 |
| 4853 | NOTCH2 | 2606 | NP_077719.2 | in vivo | 10958687 |
| 4854 | NOTCH3 | 2607 | NP_000426.2 | in vitro;in vivo | 1 248 295 411 006 130 |
| 4856 | NOV | 1291 | NP_002505.1 | in vitro;in vivo | 12050162 |
| 5663 | PSEN1 | 87 | NP_000012.1 | in vitro | 12794186 |
| 9863 | MAGI2 | 16212 | NP_036433.2 | in vitro;yeast 2-hybrid | 14529612 |
| 23509 | POFUT1 | 6319 | NP_056167.1 | in vivo | 12036964 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Notch signaling pathway | hsa04330 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00054 | 329-364 | EGF_CA |
| cl21504 | 329-364 | EGF_CA superfamily |
| cd00054 | 443-478 | EGF_CA |
| cl21504 | 443-478 | EGF_CA superfamily |
| cd00054 | 288-326 | EGF_CA |
| cl21504 | 288-326 | EGF_CA superfamily |
| cd00054 | 406-440 | EGF_CA |
| cl21504 | 406-440 | EGF_CA superfamily |
| cd00054 | 373-403 | EGF_CA |
| cl21504 | 373-403 | EGF_CA superfamily |
| cd00054 | 489-517 | EGF_CA |
| cl21504 | 489-517 | EGF_CA superfamily |
| pfam07657 | 21-95 | MNNL |
| cl06622 | 21-95 | MNNL superfamily |
| pfam01414 | 159-221 | DSL |
| cl19567 | 159-221 | DSL superfamily |
| smart00051 | 159-221 | DSL |
| smart00179 | 329-364 | EGF_CA |
| smart00179 | 443-478 | EGF_CA |
| smart00179 | 288-326 | EGF_CA |
| cd00053 | 448-477 | EGF |
| smart00179 | 406-441 | EGF_CA |
| cd00053 | 292-326 | EGF |
| cd00053 | 331-361 | EGF |
| pfam00008 | 450-477 | EGF |
| pfam00008 | 333-361 | EGF |
Ontology Information
| HPRD ID | 18180 |
|---|---|
| Molecular Class | Calcium binding protein |
| Molecular Function | Extracellular matrix structural constituent (GO:0005201) |
| Biological Process | Cell-matrix adhesion (GO:0007160) |
Drug Information
No matching records could be found.