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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21868509 | 2011 | Cell line : - Source : University Hospital Mannheim. Sample Type : CRC tumor and adjacent normal tissues No. of Sample : 32 Stage : TNM Stage I-IV | ELISA, real-time PCR, immunohistochemistry | Up-regulation | - | The expression of TRXR-1, GPX1 and GPX4, but not TRXR-2 is differently regulated in cancer as compared to healthy colonic tissue.GPX4 was also up-regulated at the protein level, except for the samples derived from stage III patients. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the glutathione peroxidase protein family. Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Human plasma glutathione peroxidase has been shown to be a selenium-containing enzyme and the UGA codon is translated into a selenocysteine. The encoded protein has been identified as a moonlighting protein based on its ability to serve dual functions as a peroxidase as well as a structural protein in mature spermatozoa. Through alternative splicing and transcription initiation, rat produces proteins that localize to the nucleus, mitochondrion, and cytoplasm. In humans, alternative transcription initiation and the cleavage sites of the mitochondrial and nuclear transit peptides need to be experimentally verified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] |
| Chromosome | 19 |
| Location | 19p13.3 |
| Start | 1103936 |
| End | 1106787 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 2852 |
| OMIM ID | 138322 |
| HGNC ID | HGNC:4556 |
| Unigene ID | Hs.433951 |
| Ensembl ID | - |
| PharmGKB ID | PA28952 |
mRNA Information
| mRNA ID | NM_001039847.2 |
|---|---|
| Exon | join(1..202,1261..1355,1441..1585,1733..1884,2317..2341, 2453..2534,2615..2864) | mRNA Sequence | Download Select all |
| Length | 958 |
Protein Information
| Protein ID | NP_001034936.1 |
|---|---|
| Protein Name | glutathione peroxidase 4 |
| Molecular Wt. (Da) | 22556 |
| Protein Sequence | Download Select all |
| Length | 227 |
| Uniprot ID | P23921 |
| Ensembl Protein ID | ENSP00000300738 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| K | Acetylation | 47 |
| K | Acetylation | 47 |
| K | Acetylation | 84 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Glutathione metabolism | hsa00480 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00340 | 40-193 | GSH_Peroxidase |
| cl00388 | 40-193 | Thioredoxin_like superfamily |
| COG0386 | 40-192 | BtuE |
| pfam00255 | 41-148 | GSHPx |
| PLN02399 | 39-193 | PLN02399 |
| PLN02412 | 39-193 | PLN02412 |
| PTZ00256 | 38-193 | PTZ00256 |
| PRK10606 | 47-190 | btuE |
| PTZ00056 | 39-193 | PTZ00056 |
| TIGR02540 | 40-187 | gpx7 |
| cd02966 | 43-180 | TlpA_like_family |
Ontology Information
| HPRD ID | 1587 |
|---|---|
| Molecular Class | Enzyme: Peroxidase |
| Molecular Function | Oxidoreductase activity (GO:0016491) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P36969 | DB00143 | Glutathione | SmallMoleculeDrug |