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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
NR3C1 2908 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)  5GR 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
17167179   2006Cell line : -

Source : -

Sample Type : CRC tumor and adjacent normal tissues

No. of Sample : Tumors (n=198), normal tissues (n=44), and cell lines (n=30)

Stage : -

Microarrays,methylation-specific PCR, bisulphite sequencing, and quantitative gene expression analysisMethylation-Genes with cancer-specific hypermethylation in colorectal tumors, ADAMTS1, CRABP1, and NR3C1.


Gene Details



NC_000005.9 (142657496..143113322, complement)

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Gene Type protein coding
Gene Family Nuclear hormone receptors
Description This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]  
Chromosome 5
Location 5q31-q32
Start 142657496  
End 143113322  
Strand -  
Gene Sequence

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Length 455827  
OMIM ID 138040   
HGNC ID HGNC:7978   
Unigene ID Hs.122926   
Ensembl ID ENSG00000113580   
PharmGKB ID PA181   

mRNA Information


mRNA ID NM_001018075.1
Exon join(1..212,34661..35857,121345..121511,125300..125416, 134750..135028,136701..136845,139923..140053, 152788..152945,153472..157582)  
mRNA Sequence

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Length 6517  



CDS Information


   
Location 226..2559
CDS Sequence

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CCDS ID CCDS34258.1



Protein Information


      
Protein IDNP_001018085.1
Protein Namenuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Molecular Wt. (Da)85529
Protein Sequence

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Length 777  
Uniprot IDP31350
Ensembl Protein ID ENSP00000302955  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation113
SPhosphorylation141
SPhosphorylation203
SPhosphorylation211
KSumoylation277
KSumoylation293
KUbiquitination419
KSumoylation703
SPhosphorylation113
SPhosphorylation141
SPhosphorylation203
SPhosphorylation211
KSumoylation277
KSumoylation293
KUbiquitination419
KSumoylation703
SPhosphorylation113
SPhosphorylation141
SPhosphorylation203
SPhosphorylation211
KSumoylation277
KSumoylation293
KUbiquitination419
KSumoylation703
SPhosphorylation113
SPhosphorylation141
SPhosphorylation203
SPhosphorylation211
KSumoylation277
KSumoylation293
KUbiquitination419
KSumoylation703
SPhosphorylation113
SPhosphorylation141
SPhosphorylation203
SPhosphorylation211
KSumoylation277
KSumoylation293
KUbiquitination419
KSumoylation703
SPhosphorylation113
SPhosphorylation141
SPhosphorylation203
SPhosphorylation211
KSumoylation277
KSumoylation293
KUbiquitination419
KSumoylation703
SPhosphorylation113
SPhosphorylation141
SPhosphorylation203
SPhosphorylation211
KSumoylation277
KSumoylation293
KUbiquitination419
KSumoylation704
SPhosphorylation226
SPhosphorylation226
SPhosphorylation226
SPhosphorylation226
SPhosphorylation226
SPhosphorylation226
SPhosphorylation226
SPhosphorylation508
SPhosphorylation508
SPhosphorylation508
SPhosphorylation508
SPhosphorylation508
SPhosphorylation508
SPhosphorylation509
SPhosphorylation226
SPhosphorylation226
SPhosphorylation226
SPhosphorylation226
SPhosphorylation226
SPhosphorylation226
SPhosphorylation226
KSumoylation277
KSumoylation293
KSumoylation703
KSumoylation277
KSumoylation293
KSumoylation703
KSumoylation277
KSumoylation293
KSumoylation703
KSumoylation277
KSumoylation293
KSumoylation703
KSumoylation277
KSumoylation293
KSumoylation703
KSumoylation277
KSumoylation293
KSumoylation703
TPhosphorylation8
TPhosphorylation8
TPhosphorylation8
TPhosphorylation8
TPhosphorylation8
TPhosphorylation8
TPhosphorylation8
SPhosphorylation45
SPhosphorylation45
SPhosphorylation45
SPhosphorylation45
SPhosphorylation45
SPhosphorylation45
SPhosphorylation45
SPhosphorylation134
SPhosphorylation134
SPhosphorylation134
SPhosphorylation134
SPhosphorylation134
SPhosphorylation134
SPhosphorylation134
SPhosphorylation234
SPhosphorylation234
SPhosphorylation234
SPhosphorylation234
SPhosphorylation234
SPhosphorylation234
SPhosphorylation234
SPhosphorylation267
SPhosphorylation267
SPhosphorylation267
SPhosphorylation267
SPhosphorylation267
SPhosphorylation267
SPhosphorylation267
SPhosphorylation266
SPhosphorylation266
SPhosphorylation266
SPhosphorylation266
SPhosphorylation266
SPhosphorylation266
SPhosphorylation266
TPhosphorylation32
TPhosphorylation38
TPhosphorylation32
TPhosphorylation38
TPhosphorylation32
TPhosphorylation38
TPhosphorylation32
TPhosphorylation38
TPhosphorylation32
TPhosphorylation38
TPhosphorylation32
TPhosphorylation38
TPhosphorylation32
TPhosphorylation38
YPhosphorylation648
SPhosphorylation650
SPhosphorylation651
YPhosphorylation648
SPhosphorylation650
SPhosphorylation651
YPhosphorylation648
SPhosphorylation650
SPhosphorylation651
YPhosphorylation648
SPhosphorylation650
SPhosphorylation651
YPhosphorylation648
SPhosphorylation650
SPhosphorylation651
YPhosphorylation648
SPhosphorylation650
SPhosphorylation651
YPhosphorylation649
SPhosphorylation651
SPhosphorylation652

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                    
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
100ADA38NP_000013.2in vitro9154805   
291SLC25A458NP_001142.2in vivo12039962   
801CALM1241NP_008819.1in vitro;in vivo7887964   
811CALR169NP_004334.1in vivo81   078   089   089   287   
1050CEBPA296NP_004355.2in vitro;in vivo11818365   
1385CREB1442NP_604391.1in vitro76   219   018   449   898   
2063NR2F6583NP_005225.2in vitro10713182   
2534FYN655NP_002028.1in vivo16888650   
3932LCK1080NP_005347.3in vivo16888650   
6774STAT326NP_644805.1in vivo145   229   529   388   192   
7026NR2F2139NP_066285.1in vitro;in vivo;yeast 2-hybrid14739255   
7533YWHAH215NP_003396.1in vitro;yeast 2-hybrid90   796   301   273   023   700   000   000   


Pathway Information


      
Pathway Name Pathway ID
Neuroactive ligand-receptor interaction hsa04080


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd07076531-777  NR_LBD_GR
cl11397531-777  NR_LBD superfamily
cd07172417-494  NR_DBD_GR_PR
cl02596417-494  NR_DBD_like superfamily
pfam0215526-401  GCR
cl0346926-401  GCR superfamily
cd06947531-775  NR_LBD_GR_Like
cd07075531-777  NR_LBD_MR
cd07074532-777  NR_LBD_PR
cd07073532-775  NR_LBD_AR
cd06930560-728  NR_LBD_F2
cd06963421-493  NR_DBD_GR_like
cd07173416-495  NR_DBD_AR
cd06157561-728  NR_LBD
cd06916421-492  NR_DBD_like
pfam00105419-488  zf-C4
cd07068532-722  NR_LBD_ER_like
pfam00104542-737  Hormone_recep
smart00399420-489  ZnF_C4
smart00430569-728  HOLI
cd07171417-496  NR_DBD_ER
cd06960421-490  NR_DBD_HNF4A
cd06946532-674  NR_LBD_ERR
cd07167421-490  NR_DBD_Lrh-1_like
cd06949532-722  NR_LBD_ER
cd06961420-498  NR_DBD_TR
cd07155421-486  NR_DBD_ER_like
cd07170416-486  NR_DBD_ERR
cd06969419-493  NR_DBD_NGFI-B
cd07168418-490  NR_DBD_DHR4_like
cd07164421-490  NR_DBD_PNR_like_1
cd06956420-490  NR_DBD_RXR
cd07154421-490  NR_DBD_PNR_like
cd06970414-502  NR_DBD_PNR
cd06967416-496  NR_DBD_TR2_like
cd07169419-490  NR_DBD_GCNF_like
cd06964419-496  NR_DBD_RAR
cd06959420-486  NR_DBD_EcR_like
cd07156421-486  NR_DBD_VDR_like
cd07179421-492  2DBD_NR_DBD2
cd07163421-490  NR_DBD_TLX
cd06958421-490  NR_DBD_COUP_TF
cd07160415-498  NR_DBD_LXR
cd06957421-495  NR_DBD_PNR_like_2
cd07165421-490  NR_DBD_DmE78_like
cd06968421-492  NR_DBD_ROR
cd07161419-489  NR_DBD_EcR
cd06966419-489  NR_DBD_CAR
cd06962419-498  NR_DBD_FXR
cd07166420-492  NR_DBD_REV_ERB
cd07162420-489  NR_DBD_PXR
cd07158421-490  NR_DBD_Ppar_like
cd06955418-498  NR_DBD_VDR
cd07157419-488  2DBD_NR_DBD1
cd06965420-490  NR_DBD_Ppar
cd06943569-690  NR_LBD_RXR_like
cd06944572-673  NR_LBD_Ftz-F1_like
cd07070572-673  NR_LBD_SF-1
cd06929575-734  NR_LBD_F1
cd06950527-681  NR_LBD_Tlx_PNR_like
cd06945548-697  NR_LBD_Nurr1_like
cd06948566-674  NR_LBD_COUP-TF
cd06931570-671  NR_LBD_HNF4_like
cd07069566-674  NR_LBD_Lrh-1
cd06953566-734  NR_LBD_DHR4_like
cd07348576-681  NR_LBD_NGFI-B
cd06941575-674  NR_LBD_DmE78_like
cd06935571-723  NR_LBD_TR
cd07072577-697  NR_LBD_DHR38_like
cd06940575-725  NR_LBD_REV_ERB
cd06942573-733  NR_LBD_Sex_1_like
cd06932576-598  NR_LBD_PPAR
cd06952567-673  NR_LBD_TR2_like
cd07071554-728  NR_LBD_Nurr1


Ontology Information


   
HPRD ID2921
Molecular ClassNuclear receptor
Molecular FunctionSignal transducer activity (GO:0004871)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P04150DB00180FlunisolideSmallMoleculeDrug
P04150DB00223DiflorasoneSmallMoleculeDrug
P04150DB00240AlclometasoneSmallMoleculeDrug
P04150DB00253MedrysoneSmallMoleculeDrug
P04150DB00288AmcinonideSmallMoleculeDrug
P04150DB00324FluorometholoneSmallMoleculeDrug
P04150DB00351Megestrol acetateSmallMoleculeDrug
P04150DB00394BeclomethasoneSmallMoleculeDrug
P04150DB00421SpironolactoneSmallMoleculeDrug
P04150DB00443BetamethasoneSmallMoleculeDrug
P04150DB00547DesoximetasoneSmallMoleculeDrug
P04150DB00588Fluticasone PropionateSmallMoleculeDrug
P04150DB00591Fluocinolone AcetonideSmallMoleculeDrug
P04150DB00596Halobetasol PropionateSmallMoleculeDrug
P04150DB00620TriamcinoloneSmallMoleculeDrug
P04150DB00635PrednisoneSmallMoleculeDrug
P04150DB00663Flumethasone PivalateSmallMoleculeDrug
P04150DB00687FludrocortisoneSmallMoleculeDrug
P04150DB00741HydrocortisoneSmallMoleculeDrug
P04150DB00764MometasoneSmallMoleculeDrug
P04150DB00769HydrocortamateSmallMoleculeDrug
P04150DB00834MifepristoneSmallMoleculeDrug
P04150DB00838ClocortoloneSmallMoleculeDrug
P04150DB00846FlurandrenolideSmallMoleculeDrug
P04150DB00860PrednisoloneSmallMoleculeDrug
P04150DB00873LoteprednolSmallMoleculeDrug
P04150DB00896RimexoloneSmallMoleculeDrug
P04150DB00959MethylprednisoloneSmallMoleculeDrug
P04150DB01013Clobetasol propionateSmallMoleculeDrug
P04150DB01047FluocinonideSmallMoleculeDrug
P04150DB01130PrednicarbateSmallMoleculeDrug
P04150DB01185FluoxymesteroneSmallMoleculeDrug
P04150DB01222BudesonideSmallMoleculeDrug
P04150DB01234DexamethasoneSmallMoleculeDrug
P04150DB01260DesonideSmallMoleculeDrug
P04150DB01380Cortisone acetateSmallMoleculeDrug
P04150DB01384ParamethasoneSmallMoleculeDrug
P04150DB01410CiclesonideSmallMoleculeDrug
P04150DB06781DifluprednateSmallMoleculeDrug
P04150DB08867UlipristalSmallMoleculeDrug
P04150DB08906Fluticasone furoateSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO