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General Information
- Evidence
- Gene
- mRNA
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- Protein
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24958816 | 2014 | Cell line : Caco 2, HT 29 Source : Gift from Richard Benya, Loyola Medicine Chicago Sample Type : - No. of Sample : - Stage : - | Western Blotting, Pull-Down Assay,Coimmunoprecipitation Assay,Cell Migration Assays,ELISA | Up-regulation | - | Results have uncovered a key mechanism for GRPR-regulated colon cancer cell migration through the G?13-PRG-RhoA-ROCK pathway. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | GPCR / Class A : Bombesin receptors |
| Description | Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene. [provided by RefSeq, Jul 2008] |
| Chromosome | X |
| Location | Xp22.2 |
| Start | 16141424 |
| End | 16171641 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 30218 |
| OMIM ID | 305670 |
| HGNC ID | HGNC:4609 |
| Unigene ID | Hs.567282 |
| Ensembl ID | ENSG00000126010 |
| PharmGKB ID | PA29002 |
mRNA Information
| mRNA ID | NM_005314.2 |
|---|---|
| Exon | join(1..1066,27005..27356,28956..30218) | mRNA Sequence | Download Select all |
| Length | 2681 |
Protein Information
| Protein ID | NP_005305.1 |
|---|---|
| Protein Name | gastrin-releasing peptide receptor |
| Molecular Wt. (Da) | 43068 |
| Protein Sequence | Download Select all |
| Length | 384 |
| Uniprot ID | P19793 |
| Ensembl Protein ID | ENSP00000419692 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Calcium signaling pathway | hsa04020 |
| Neuroactive ligand-receptor interaction | hsa04080 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00001 | 64-320 | 7tm_1 |
| PHA03087 | 101-331 | PHA03087 |
| PHA02834 | 104-351 | PHA02834 |
| PHA02638 | 104-330 | PHA02638 |
| PHA03235 | 102-333 | PHA03235 |
Ontology Information
| HPRD ID | 1508 |
|---|---|
| Molecular Class | G protein coupled receptor |
| Molecular Function | Calcium ion binding (GO:0005509) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.