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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
GSPT1 2935 G1 to S phase transition 1  16GST1, ETF3A, eRF3a 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
26349975   2015Cell line : HCT116

Source : -

Sample Type : -

No. of Sample : -

Stage : -

 luciferase reporter assayUp-regulation-miRNA-144 suppressed the expression of GSPT1 to regulate the expression of c-myc, survivin and Bcl2L15 which are involved in cell proliferation, and that metastasis related factor MMP28 was also down-regulated by miRNA144.


Gene Details



NC_000016.9 (11961985..12010519, complement)

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Gene Type protein coding
Gene Family -
Description -  
Chromosome 16
Location 16p13.1
Start 11961985  
End 12010519  
Strand -  
Gene Sequence

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Length 48535  
OMIM ID 139259   
HGNC ID HGNC:4621   
Unigene ID Hs.528780   
Ensembl ID -   
PharmGKB ID PA29012   

mRNA Information


mRNA ID NM_001130007.1
Exon join(1..621,18628..18669,18782..18823,19878..20105, 21676..21709,25524..25601,28913..29093,29732..29886, 30052..30192,31389..31482,33568..33648,39083..39256, 40488..40577,40734..40902,43492..48535)  
mRNA Sequence

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Length 7190  



CDS Information


   
Location684..2183
CDS Sequence

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CCDS ID CCDS45412.1



Protein Information


      
Protein IDNP_001123479.1
Protein NameG1 to S phase transition 1
Molecular Wt. (Da)55625
Protein Sequence

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Length 499  
Uniprot IDP33764
Ensembl Protein ID ENSP00000357701  



Post-translational Modification Information (Source : HPRD)


Residue Type site
KAcetylation631
KAcetylation628
KAcetylation246
KAcetylation334
TPhosphorylation227
TPhosphorylation236

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
6310ATXN13333NP_000323.2yeast 2-hybrid16713569   


Pathway Information


      
Pathway Name Pathway ID
mRNA surveillance pathway hsa03015


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0188376-292  EF1_alpha
cl2145576-292  P-loop_NTPase superfamily
cd03704388-494  eRF3c_III
cl02786388-494  Translation_factor_III superfamily
cd04089301-382  eRF3_II
cl02787301-382  Translation_Factor_II_like superfamily
pfam0000972-271  GTP_EFTU
cd0416676-292  CysN_ATPS
cd0088176-266  GTP_translation_factor
cd03698301-382  eRF3_II_like
cd0188474-223  EF_Tu
cd04093391-494  HBS1_C
cd03705392-491  EF1_alpha_III
pfam03143391-495  GTP_EFTU_D3
cd0417181-271  SelB
cd01513393-491  Translation_factor_III
cd0188875-251  eIF2_gamma
cd0188777-271  IF2_eIF5B
cd0416882-253  TetM_like
cd0188975-266  SelB_euk
cd0417076-243  EF-G_bact
cd03696303-382  selB_II
cd03708391-494  GTPBP_III
cd01342303-382  Translation_Factor_II_like
cd03693298-385  EF1_alpha_II
pfam03144314-381  GTP_EFTU_D2
cd0189076-271  LepA
cd0416776-223  Snu114p
cd0189176-225  TypA_BipA
cd0416980-226  RF3
cd0088278-271  Ras_like_GTPase
cd03697304-384  EFTU_II
cd00880173-271  Era_like
cd0188676-165  EF-G
cd03694314-380  GTPBP_II
COG525672-496  TEF1
PRK1231769-498  PRK12317
PTZ0014172-499  PTZ00141
TIGR0048369-498  EF-1_alpha
PLN0004371-499  PLN00043
COG289571-498  CysN
TIGR0203481-491  CysN
PRK0550681-489  PRK05506
PRK0512481-398  cysN
COG005072-400  TufB
COG327675-433  SelB
TIGR0048571-400  EF-Tu
CHL0007171-400  tufA
PLN0312671-495  PLN03126
PRK1273672-400  PRK12736
PLN0312772-400  PLN03127
PRK1273571-384  PRK12735
PRK0004972-399  PRK00049
TIGR0047575-438  selB
COG525872-456  GTPBP1
TIGR0368075-269  eif2g_arch
PRK1021876-386  PRK10218
PRK1051281-374  PRK10512
PRK0400075-246  PRK04000
COG525775-246  GCD11
COG048076-223  FusA
PRK1274080-241  PRK12740
TIGR0048768-271  IF-2
COG053277-271  InfB
TIGR0139376-360  lepA
PRK1335176-223  PRK13351
TIGR0139476-385  TypA_BipA
COG121776-385  TypA
COG048180-360  LepA
PTZ0032775-336  PTZ00327
CHL0018977-271  infB
PRK05306145-228  infB
TIGR0023175-269  small_GTP
TIGR0050376-225  prfC
PRK0543380-360  PRK05433
COG410880-223  PrfC
COG116066-271  Der
TIGR0048476-231  EF-G


Ontology Information


   
HPRD ID15914
Molecular ClassCell cycle control protein
Molecular FunctionCalcium ion binding (GO:0005509)
Biological ProcessCell growth and/or maintenance (GO:0008151)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO