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General Information
- Evidence
- Gene
- mRNA
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- Protein
- PTM
- Enzyme
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21355292 | 2011 | Cell line : SW480, SW480 CPT Source : - Sample Type : - No. of Sample : - Stage : - | Microarray, RT-PCR | Up-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Glutathione S-transferases / Soluble |
| Description | Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation. [provided by RefSeq, Jul 2008] |
| Chromosome | 6 |
| Location | 6p12.2 |
| Start | 52614885 |
| End | 52628361 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 13477 |
| OMIM ID | 138360 |
| HGNC ID | HGNC:4627 |
| Unigene ID | Hs.94107 |
| Ensembl ID | ENSG00000244067 |
| PharmGKB ID | PA29017 |
mRNA Information
| mRNA ID | NM_000846.4 |
|---|---|
| Exon | join(1..120,5587..5703,7255..7306,8489..8621,10569..10710, 11856..11987,12865..13477) | mRNA Sequence | Download Select all |
| Length | 1320 |
Protein Information
| Protein ID | NP_000837.3 |
|---|---|
| Protein Name | glutathione S-transferase alpha 2 |
| Molecular Wt. (Da) | 25533 |
| Protein Sequence | Download Select all |
| Length | 222 |
| Uniprot ID | P06703 |
| Ensembl Protein ID | ENSP00000357708 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2938 | GSTA1 | 708 | NP_665683.1 | in vitro | 1530570 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Chemical carcinogenesis | hsa05204 |
| Drug metabolism - cytochrome P450 | hsa00982 |
| Glutathione metabolism | hsa00480 |
| Metabolism of xenobiotics by cytochrome P450 | hsa00980 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd03208 | 86-220 | GST_C_Alpha |
| cl02776 | 86-220 | GST_C_family superfamily |
| cd03077 | Apr-82 | GST_N_Alpha |
| cl00388 | Apr-82 | Thioredoxin_like superfamily |
| cd03039 | May-76 | GST_N_Sigma_like |
| pfam00043 | 99-192 | GST_C |
| pfam02798 | May-77 | GST_N |
| cd03192 | 88-188 | GST_C_Sigma_like |
| cd03210 | 86-207 | GST_C_Pi |
| cd00570 | May-76 | GST_N_family |
| cd03076 | Apr-78 | GST_N_Pi |
| cd03075 | May-79 | GST_N_Mu |
| cd03046 | May-79 | GST_N_GTT1_like |
| cd03181 | 88-198 | GST_C_EF1Bgamma_like |
| cd03209 | 87-207 | GST_C_Mu |
| cd03191 | 116-196 | GST_C_Zeta |
| cd10293 | 130-196 | GST_C_Ure2p |
| cd03056 | 19-76 | GST_N_4 |
| cd00299 | 90-188 | GST_C_family |
| cd03053 | 23-78 | GST_N_Phi |
| cd03188 | 118-198 | GST_C_Beta |
| cd03178 | 137-196 | GST_C_Ure2p_like |
| PTZ00057 | 1-198 | PTZ00057 |
| COG0625 | 5-197 | GstA |
| TIGR01262 | 53-207 | maiA |
| PLN02473 | 27-199 | PLN02473 |
| PLN02395 | 23-199 | PLN02395 |
Ontology Information
| HPRD ID | 2645 |
|---|---|
| Molecular Class | Enzyme: Glutathione transferase |
| Molecular Function | Calcium ion binding (GO:0005509) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P09210 | DB00143 | Glutathione | SmallMoleculeDrug |
| P09210 | DB00163 | Vitamin E | SmallMoleculeDrug |
| P09210 | DB00636 | Clofibrate | SmallMoleculeDrug |
| P09210 | DB00903 | Ethacrynic acid | SmallMoleculeDrug |
| P09210 | DB00993 | Azathioprine | SmallMoleculeDrug |
| P09210 | DB01008 | Busulfan | SmallMoleculeDrug |
| P09210 | DB00143 | Glutathione | SmallMoleculeDrug |
| P09210 | DB00608 | Chloroquine | SmallMoleculeDrug |