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General Information
- Evidence
- Gene
- mRNA
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- Protein
- PTM
- Enzyme
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- Pathway
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21355292 | 2011 | Cell line : SW480, SW480 CPT Source : - Sample Type : - No. of Sample : - Stage : - | Microarray, RT-PCR | Up-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Glutathione S-transferases / Soluble |
| Description | Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class genes that are located in a cluster mapped to chromosome 6. Genes of the alpha class are highly related and encode enzymes with glutathione peroxidase activity. However, during evolution, this alpha class gene diverged accumulating mutations in the active site that resulted in differences in substrate specificity and catalytic activity. The enzyme encoded by this gene catalyzes the double bond isomerization of precursors for progesterone and testosterone during the biosynthesis of steroid hormones. An additional transcript variant has been identified, but its full length sequence has not been determined. [provided by RefSeq, Jul 2008] |
| Chromosome | 6 |
| Location | 6p12.2 |
| Start | 52761437 |
| End | 52774496 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 13060 |
| OMIM ID | 605449 |
| HGNC ID | HGNC:4628 |
| Unigene ID | Hs.102484 |
| Ensembl ID | ENSG00000174156 |
| PharmGKB ID | PA29018 |
mRNA Information
| mRNA ID | NM_000847.4 |
|---|---|
| Exon | join(101..158,3944..4051,6072..6123,7321..7453,9724..9865, 11843..11974,12871..13160) | mRNA Sequence | Download Select all |
| Length | 915 |
Protein Information
| Protein ID | NP_000838.3 |
|---|---|
| Protein Name | glutathione S-transferase alpha 3 |
| Molecular Wt. (Da) | 25171 |
| Protein Sequence | Download Select all |
| Length | 222 |
| Uniprot ID | P31151 |
| Ensembl Protein ID | ENSP00000357711 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 49 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Chemical carcinogenesis | hsa05204 |
| Drug metabolism - cytochrome P450 | hsa00982 |
| Glutathione metabolism | hsa00480 |
| Metabolism of xenobiotics by cytochrome P450 | hsa00980 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd03208 | 86-220 | GST_C_Alpha |
| cl02776 | 86-220 | GST_C_family superfamily |
| cd03077 | Apr-82 | GST_N_Alpha |
| cl00388 | Apr-82 | Thioredoxin_like superfamily |
| cd03039 | May-76 | GST_N_Sigma_like |
| pfam02798 | May-77 | GST_N |
| cd03192 | 88-188 | GST_C_Sigma_like |
| pfam00043 | 100-192 | GST_C |
| cd03210 | 86-207 | GST_C_Pi |
| cd00570 | May-76 | GST_N_family |
| cd03076 | Apr-78 | GST_N_Pi |
| cd03075 | May-79 | GST_N_Mu |
| cd03209 | 87-211 | GST_C_Mu |
| cd03191 | 133-196 | GST_C_Zeta |
| cd10293 | 137-196 | GST_C_Ure2p |
| cd03046 | May-79 | GST_N_GTT1_like |
| cd00299 | 89-188 | GST_C_family |
| cd03181 | 88-198 | GST_C_EF1Bgamma_like |
| cd03178 | 138-196 | GST_C_Ure2p_like |
| cd03056 | 19-76 | GST_N_4 |
| cd03188 | 110-198 | GST_C_Beta |
| cd03053 | 52-78 | GST_N_Phi |
| pfam13417 | 19-79 | GST_N_3 |
| PTZ00057 | 1-198 | PTZ00057 |
| COG0625 | 5-197 | GstA |
| TIGR01262 | 53-207 | maiA |
| PLN02473 | 18-199 | PLN02473 |
| PLN02395 | 52-199 | PLN02395 |
Ontology Information
| HPRD ID | 471 |
|---|---|
| Molecular Class | Enzyme: Glutathione transferase |
| Molecular Function | Calcium ion binding (GO:0005509) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q16772 | DB00143 | Glutathione | SmallMoleculeDrug |