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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| GSTM3 | 2947 | glutathione S-transferase mu 3 (brain) | 1 | GST5 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22430872 | 2012 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 189 Stage : UICC stage II,III. | MALDI imaging,immunohistochemistry. | Up-regulation | - | GSTM3 was more highly expressed in UICC III patient tumour tissues. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Glutathione S-transferases / Soluble |
| Description | Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008] |
| Chromosome | 1 |
| Location | 1p13.3 |
| Start | 110276554 |
| End | 110283660 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 7107 |
| OMIM ID | 138390 |
| HGNC ID | HGNC:4635 |
| Unigene ID | Hs.2006 |
| Ensembl ID | ENSG00000134202 |
| PharmGKB ID | PA29024 |
mRNA Information
| mRNA ID | NM_000849.4 |
|---|---|
| Exon | join(1..86,528..799,1131..1206,1546..1610,2673..2754, 2848..2948,3288..3383,3472..3582,3870..7107) | mRNA Sequence | Download Select all |
| Length | 4144 |
Protein Information
| Protein ID | NP_000840.2 |
|---|---|
| Protein Name | glutathione S-transferase mu 3 (brain) |
| Molecular Wt. (Da) | 26429 |
| Protein Sequence | Download Select all |
| Length | 225 |
| Uniprot ID | P06702 |
| Ensembl Protein ID | ENSP00000357727 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 75 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2946 | GSTM2 | 710 | NP_000839.1 | in vitro | 1530570 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Chemical carcinogenesis | hsa05204 |
| Drug metabolism - cytochrome P450 | hsa00982 |
| Glutathione metabolism | hsa00480 |
| Metabolism of xenobiotics by cytochrome P450 | hsa00980 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd03209 | 96-216 | GST_C_Mu |
| cl02776 | 96-216 | GST_C_family superfamily |
| cd03075 | Jul-88 | GST_N_Mu |
| cl00388 | Jul-88 | Thioredoxin_like superfamily |
| cd03039 | Jul-86 | GST_N_Sigma_like |
| cd03210 | 95-213 | GST_C_Pi |
| pfam02798 | Jul-86 | GST_N |
| pfam00043 | 108-196 | GST_C |
| cd03192 | 96-188 | GST_C_Sigma_like |
| cd03076 | Aug-87 | GST_N_Pi |
| cd00570 | Jul-85 | GST_N_family |
| cd00299 | 101-191 | GST_C_family |
| cd03077 | Aug-90 | GST_N_Alpha |
| pfam14497 | 133-194 | GST_C_3 |
| cd03183 | 125-194 | GST_C_Theta |
| cd03053 | 61-87 | GST_N_Phi |
| cd03056 | 16-85 | GST_N_4 |
| cd10295 | 95-187 | GST_C_Sigma |
| cd03188 | 111-202 | GST_C_Beta |
| PTZ00057 | 6-204 | PTZ00057 |
| COG0625 | 7-195 | GstA |
| PLN02395 | 61-161 | PLN02395 |
Ontology Information
| HPRD ID | 232 |
|---|---|
| Molecular Class | Enzyme: Glutathione transferase |
| Molecular Function | Calcium ion binding (GO:0005509) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P21266 | DB00163 | Vitamin E | SmallMoleculeDrug |
| P21266 | DB00143 | Glutathione | SmallMoleculeDrug |