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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24970398 | 2014 | Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 10 Stage : - | Immunohistochemistry, western blotting, methylation-specific PCR, chromatin immunoprecipitation | Methylation, Up-regulation | - | GSTP-1 may serve as a clinically useful biomarker of colon cancer and a target for anti-colon cancer drugs. expression of GSTP-1 protein was higher in tumor tissues than in paired adjacent normal tissues. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Glutathione S-transferases / Soluble |
| Description | Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. |
| Chromosome | 11 |
| Location | 11q13.2 |
| Start | 67583595 |
| End | 67586653 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 3059 |
| OMIM ID | 134660 |
| HGNC ID | HGNC:4638 |
| Unigene ID | Hs.523836 |
| Ensembl ID | ENSG00000084207 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_000852.3 |
|---|---|
| Exon | join(1..250,540..575,870..976,1091..1178,1544..1647, 2510..2617,2795..3059) | mRNA Sequence | Download Select all |
| Length | 986 |
CDS Information
| Location | join(250,540..575,870..976,1091..1178,1544..1647, 2510..2617,2795..2983) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS41679.1 |
Protein Information
| Protein ID | NP_000843.1 |
|---|---|
| Protein Name | glutathione S-transferase pi 1 |
| Molecular Wt. (Da) | 23225 |
| Protein Sequence | Download Select all |
| Length | 210 |
| Uniprot ID | P0C0S5 |
| Ensembl Protein ID | ENSP00000296417 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| K | Acetylation | 128 |
| K | Acetylation | 121 |
| S | Phosphorylation | 43 |
Enzyme Information
| EC | 2.5.1.18 |
|---|---|
| Name | glutathione transferase glutathione S-transferase glutathione S-alkyltransferase glutathione S-aryltransferase S-(hydroxyalkyl)glutathione lyase glutathione S-aralkyltransferase glutathione S-alkyl transferase GST |
| Class | Transferases; Transferring alkyl or aryl groups, other than methyl groups; Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date) |
| Sysname | RX:glutathione R-transferase |
| Substrate | RX [CPD:C01322]; glutathione [CPD:C00051] |
| Product | HX [CPD:C00462]; R-S-glutathione [CPD:C02320] |
| Reaction (IUBMB) |  |
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2176 | FANCC | 1967 | NP_000127.2 | in vitro;in vivo | 11433346 |
| 5764 | PTN | 1199 | NP_002816.1 | yeast 2-hybrid | 16169070 |
| 7186 | TRAF2 | 3538 | NP_066961.2 | in vitro;in vivo | 16636664 |
| 56902 | PNO1 | 14250 | NP_064528.1 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Chemical carcinogenesis | hsa05204 |
| Drug metabolism - cytochrome P450 | hsa00982 |
| Glutathione metabolism | hsa00480 |
| Metabolism of xenobiotics by cytochrome P450 | hsa00980 |
| Pathways in cancer | hsa05200 |
| Prostate cancer | hsa05215 |
Structure Information
| PDB ID | 10GS |
|---|---|
| Resolution | 2.2 |
| Method | ?? X-RAY DIFFRACTION |
| Chains | A, B |
| Molecule | GLUTATHIONE S-TRANSFERASE P1-1 |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd03210 | 84-210 | GST_C_Pi |
| cl02776 | 84-210 | GST_C_family superfamily |
| cd03076 | Mar-76 | GST_N_Pi |
| cl00388 | Mar-76 | Thioredoxin_like superfamily |
| cd03209 | 85-206 | GST_C_Mu |
| cd03039 | Apr-75 | GST_N_Sigma_like |
| cd03192 | 85-183 | GST_C_Sigma_like |
| pfam00043 | 97-188 | GST_C |
| pfam02798 | Apr-75 | GST_N |
| cd03208 | 84-195 | GST_C_Alpha |
| cd00570 | Apr-73 | GST_N_family |
| cd03207 | 134-189 | GST_C_8 |
| cd00299 | 88-184 | GST_C_family |
| cd03075 | May-75 | GST_N_Mu |
| cd03183 | 117-187 | GST_C_Theta |
| cd03053 | 50-75 | GST_N_Phi |
| pfam14497 | 82-186 | GST_C_3 |
| cd03184 | 102-198 | GST_C_Omega |
| cd03047 | 51-74 | GST_N_2 |
| cd03077 | Aug-80 | GST_N_Alpha |
| cd03188 | 114-194 | GST_C_Beta |
| PTZ00057 | 8-196 | PTZ00057 |
| COG0625 | 4-198 | GstA |
| TIGR01262 | 51-198 | maiA |
Ontology Information
| HPRD ID | 5521 |
|---|---|
| Molecular Class | Enzyme: Glutathione transferase |
| Molecular Function | Transcription regulator activity (GO:0030528); DNA binding (GO:0003677) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P09211 | DB00163 | Vitamin E | SmallMoleculeDrug |
| P09211 | DB00291 | Chlorambucil | SmallMoleculeDrug |
| P09211 | DB00515 | Cisplatin | SmallMoleculeDrug |
| P09211 | DB00526 | Oxaliplatin | SmallMoleculeDrug |
| P09211 | DB00773 | Etoposide | SmallMoleculeDrug |
| P09211 | DB00958 | Carboplatin | SmallMoleculeDrug |
| P09211 | DB01008 | Busulfan | SmallMoleculeDrug |
| P09211 | DB00143 | Glutathione | SmallMoleculeDrug |
| P09211 | DB01242 | Clomipramine | SmallMoleculeDrug |
| P09211 | DB04339 | Carbocisteine | SmallMoleculeDrug |