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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| GSTT2 | 2953 | glutathione S-transferase theta 2 (gene/pseudogene) | 22 | - |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17250773 | 2007 | Cell line : - Source : Seoul National University Hospital and the National Cancer Center Hospital, Korea. Sample Type : CRC tumor and normal tissues No. of Sample : 436 Stage : TNM stage I-IV | Genotyping,real-time TaqMan assay,direct sequencing,EMSA | Polymorhpism | - | SNPs and haplotypes of the GSTT2 promoter region are associated with colorectal cancer risk in the Korean population. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Glutathione S-transferases / Soluble |
| Description | The protein encoded by this gene, glutathione S-transferase (GST) theta 2 (GSTT2), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT2 and GSTT2B are nearly identical to each other, and share 55% amino acid identity with GSTT1. All three genes may play a role in human carcinogenesis. The GSTT2 gene is a pseudogene in some populations. [provided by RefSeq, Sep 2015] |
| Chromosome | 22 |
| Location | 22q11.23 |
| Start | 24322291 |
| End | 24326106 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 3816 |
| OMIM ID | 600437 |
| HGNC ID | HGNC:4642 |
| Unigene ID | Hs.654462 |
| Ensembl ID | ENSG00000099984 |
| PharmGKB ID | - |
Protein Information
| Protein ID | |
|---|---|
| Protein Name | glutathione S-transferase theta 2 (gene/pseudogene) |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 0 |
| Uniprot ID | P31949 |
| Ensembl Protein ID | ENSP00000271638 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 137 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Chemical carcinogenesis | hsa05204 |
| Drug metabolism - cytochrome P450 | hsa00982 |
| Glutathione metabolism | hsa00480 |
| Metabolism of xenobiotics by cytochrome P450 | hsa00980 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd03183 | 91-216 | GST_C_Theta |
| cl02776 | 91-216 | GST_C_family superfamily |
| cd03050 | Mar-78 | GST_N_Theta |
| cl00388 | Mar-78 | Thioredoxin_like superfamily |
| cd03045 | Mar-74 | GST_N_Delta_Epsilon |
| cd00570 | Mar-74 | GST_N_family |
| cd03056 | 25-75 | GST_N_4 |
| cd03053 | Mar-77 | GST_N_Phi |
| cd03046 | 25-78 | GST_N_GTT1_like |
| cd03048 | 17-80 | GST_N_Ure2p_like |
| cd03042 | 25-74 | GST_N_Zeta |
| cd03051 | May-74 | GST_N_GTT2_like |
| cd03057 | 14-74 | GST_N_Beta |
| cd03177 | 124-210 | GST_C_Delta_Epsilon |
| pfam00043 | 128-199 | GST_C |
| cd00299 | 95-197 | GST_C_family |
| pfam02798 | 19-74 | GST_N |
| pfam13417 | 14-74 | GST_N_3 |
| cd03044 | 14-75 | GST_N_EF1Bgamma |
| cd03047 | 44-75 | GST_N_2 |
| pfam13409 | 14-74 | GST_N_2 |
| cd03181 | 112-169 | GST_C_EF1Bgamma_like |
| pfam13410 | 132-196 | GST_C_2 |
| cd03182 | 125-199 | GST_C_GTT2_like |
| cd03188 | 91-199 | GST_C_Beta |
| cd03207 | 98-199 | GST_C_8 |
| cd03059 | Aug-78 | GST_N_SspA |
| cd03187 | 115-193 | GST_C_Phi |
| cd03192 | 126-197 | GST_C_Sigma_like |
| cd03209 | 148-199 | GST_C_Mu |
| cd03189 | 140-199 | GST_C_GTT1_like |
| cd03190 | 141-167 | GST_C_Omega_like |
| cd03043 | 21-74 | GST_N_1 |
| cd03039 | 52-74 | GST_N_Sigma_like |
| cd03205 | 132-199 | GST_C_6 |
| cd03054 | 16-74 | GST_N_Metaxin |
| COG0625 | 14-210 | GstA |
| PRK15113 | 16-101 | PRK15113 |
| PLN02395 | 1-193 | PLN02395 |
| TIGR01262 | 25-167 | maiA |
| PRK10542 | 14-199 | PRK10542 |
| PLN02473 | 13-199 | PLN02473 |
| PRK11752 | 33-169 | PRK11752 |
| PLN02378 | 20-181 | PLN02378 |
| PRK13972 | 7-167 | PRK13972 |
| COG0435 | 133-166 | ECM4 |
Ontology Information
| HPRD ID | 1505 |
|---|---|
| Molecular Class | Enzyme: Glutathione transferase |
| Molecular Function | Calcium ion binding (GO:0005509) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.