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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
GUCY2C 2984 guanylate cyclase 2C (heat stable enterotoxin receptor)  12STAR 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
10610624   1999Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

RT-PCRUp-regulation-Expression of guanylyl cyclase C mRNA in lymph nodes is associated with recurrence of colorectal cancer in patients with stage II disease. Analysis of guanylyl cyclase mRNA expression by RT-PCR may be useful for colorectal cancer staging.

Guanylyl cyclase C mRNA was expressed in lymph nodes from all patients with recurrent disease but not in those from patients without recurrent disease (P = 0.004).

9641495   1998Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

RT-PCRUp-regulation-GCC is heterogeneously expressed by colorectal cancercells in vitro and suggest a role for quantitative RT-PCR analysis in the development of diagnostic tests using GCC as a biomarkerfor metastatic colorectal cancer.


Gene Details



Chromosome 12 - NC_000012.12 (14612632..14696618, complement)

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Gene Type protein coding
Gene Family
Description -  
Chromosome 12
Location 12p12
Start 14612632  
End 14696618  
Strand -  
Gene Sequence

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Length 83987  
OMIM ID 601330   
HGNC ID HGNC:4688   
Unigene ID Hs.524278   
Ensembl ID ENSG00000070019   
PharmGKB ID -   

mRNA Information


mRNA ID NM_004963.3
Exon join(34..387,8556..8668,10394..10458,13362..13577, 15142..15263,16866..16962,19648..19765,21859..21994, 23661..23746,26786..26897,35557..35638,40002..40107, 43605..43667,44589..44660,45108..45212,51304..51390, 52913..53045,55400..55537,56669..56757,67882..67973, 70704..70862,74422..74614,75403..75577,77310..77408, 79892..79986,81676..81752,83328..83987)  
mRNA Sequence

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Length 3850  



CDS Information


   
Location join(171..387,8556..8668,10394..10458,13362..13577, 15142..15263,16866..16962,19648..19765,21859..21994, 23661..23746,26786..26897,35557..35638,40002..40107, 43605..43667,44589..44660,45108..45212,51304..51390, 52913..53045,55400..55537,56669..56757,67882..67973, 70704..70862,74422..74614,75403..75577,77310..77408, 79892..79986,81676..81752,83328..83502)
CDS Sequence

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CCDS ID CCDS8664.1



Protein Information


      
Protein IDNP_004954.2
Protein Nameguanylate cyclase 2C (heat stable enterotoxin receptor)
Molecular Wt. (Da)120741
Protein Sequence

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Length 1073  
Uniprot IDQ92839
Ensembl Protein ID ENSP00000222115  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation965
KAcetylation392

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                             
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
2980GUCA2A767NP_291031.2in vitro;in vivo1   060   186   511   889   120   
6714SRC1819NP_005408.1in vitro;in vivo12649275   
79849PDZD36191NP_079067.2in vitro;in vivo;yeast 2-hybrid11950846   


Pathway Information


      
Pathway Name Pathway ID
Purine metabolism hsa00230


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0636935-415  PBP1_GC_C_enterotoxin_receptor
cl1001135-415  Periplasmic_Binding_Protein_Type_1 superfamily
cd14044480-750  PK_GC-C
cl21453480-750  PKc_like superfamily
cd07302822-1000  CHD
cl11967822-1000  Nucleotidyl_cyc_III superfamily
cd13992493-748  PK_GC
pfam00211815-1002  Guanylate_cyc
cd0635237-407  PBP1_NPR_GC_like
cd14042498-749  PK_GC-A_B
cd14043533-741  PK_GC-2D
cd13999507-745  STKc_MAP3K-like
cd00192510-741  PTKc
cd14045508-748  PK_GC_unk
cd07556822-963  Nucleotidyl_cyc_III
cd00180505-741  PKc
cd05039508-748  PTKc_Csk_like
cd14058526-753  STKc_TAK1
cd14060526-745  STKc_MLTK
cd05122506-736  PKc_STE
cd13978541-738  STKc_RIP
cd05059521-746  PTKc_Tec_like
cd05113505-745  PTKc_Btk_Bmx
cd14066532-748  STKc_IRAK
cd14059527-741  STKc_MAP3K12_13
cd05063513-748  PTKc_EphR_A2
cd05040532-746  PTKc_Ack_like
cd05112509-746  PTKc_Itk
cd05033513-747  PTKc_EphR
cd05083505-747  PTKc_Chk
cd05038506-738  PTKc_Jak_rpt2
cd14154513-748  STKc_LIMK
cd05148509-748  PTKc_Srm_Brk
cd05066513-748  PTKc_EphR_A
cd05041536-745  PTKc_Fes_like
cd05082508-748  PTKc_Csk
cd05034532-738  PTKc_Src_like
cd05048556-745  PTKc_Ror
cd14205503-748  PTKc_Jak2_rpt2
cd05072529-745  PTKc_Lyn
cd05099513-762  PTKc_FGFR4
cd05084536-745  PTKc_Fes
cd05045513-750  PTKc_RET
cd05067532-749  PTKc_Lck_Blk
cd05060513-748  PTKc_Syk_like
cd14222511-745  STKc_LIMK2
cd05032538-741  PTKc_InsR_like
cd05081506-745  PTKc_Jak3_rpt2
cd14065510-745  PKc_LIMK_like
cd05055512-747  PTKc_PDGFR
cd05057597-747  PTKc_EGFR_like
cd05065502-748  PTKc_EphR_B
cd05101488-751  PTKc_FGFR2
cd14155533-748  PKc_TESK
cd06612522-736  STKc_MST1_2
cd14027560-742  STKc_RIP1
cd14025560-741  STKc_RIP4_like
cd05053560-748  PTKc_FGFR
cd05080513-741  PTKc_Tyk2_rpt2
cd05098530-756  PTKc_FGFR1
cd05114521-748  PTKc_Tec_Rlk
cd05079506-741  PTKc_Jak1_rpt2
cd14001487-741  PKc_TOPK
cd14221539-745  STKc_LIMK1
cd05046513-747  PTK_CCK4
cd05037509-741  PTK_Jak_rpt1
cd14063585-748  PK_KSR
cd05092509-745  PTKc_TrkA
cd05047532-748  PTKc_Tie
cd14026558-740  STKc_RIP2
cd14156528-741  PKc_LIMK_like_unk
cd05044512-745  PTKc_c-ros
cd14062530-745  STKc_Raf
cd05100530-762  PTKc_FGFR3
cd06373118-397  PBP1_NPR_like
cd05049509-747  PTKc_Trk
cd14203512-745  PTKc_Src_Fyn_like
cd05085509-746  PTKc_Fer
cd13979558-736  STKc_Mos
cd14664532-741  STK_BAK1_like
cd05091513-745  PTKc_Ror2
cd06614503-739  STKc_PAK
cd05073532-745  PTKc_Hck
cd05035596-748  PTKc_TAM
cd05050596-745  PTKc_Musk
cd05074591-750  PTKc_Tyro3
cd05052507-749  PTKc_Abl
cd05104562-741  PTKc_Kit
cd05070512-749  PTKc_Fyn
cd06627511-740  STKc_Cdc7_like
cd06610527-737  STKc_OSR1_SPAK
cd05068514-749  PTKc_Frk_like
cd14061560-748  STKc_MLK
cd05058560-750  PTKc_Met_Ron
cd05090513-745  PTKc_Ror1
cd14014509-736  STKc_PknB_like
cd05051557-745  PTKc_DDR
cd05075591-748  PTKc_Axl
cd05064538-748  PTKc_EphR_A10
cd05069529-749  PTKc_Yes
cd06609517-674  STKc_MST3_like
cd06641517-769  STKc_MST3
cd05093509-748  PTKc_TrkB
cd06626532-736  STKc_MEKK4
cd05105591-749  PTKc_PDGFR_alpha
cd05056509-748  PTKc_FAK
cd05061591-741  PTKc_InsR
cd05062532-745  PTKc_IGF-1R
cd05089532-748  PTKc_Tie1
cd05107486-750  PTKc_PDGFR_beta
cd05109597-748  PTKc_HER2
cd05088532-765  PTKc_Tie2
cd05094509-745  PTKc_TrkC
cd14207591-748  PTKc_VEGFR1
cd05106595-750  PTKc_CSF-1R
cd14145528-748  STKc_MLK1
cd05116505-745  PTKc_Syk
cd14150530-745  STKc_A-Raf
cd13997562-736  PKc_Wee1_like
cd14008508-735  STKc_LKB1_CaMKK
cd05071512-749  PTKc_Src
cd06640517-673  STKc_MST4
cd06606517-736  STKc_MAPKKK
cd14149532-745  STKc_C-Raf
cd06623507-677  PKc_MAPKK_plant_like
cd14007543-741  STKc_Aurora
cd06632487-736  STKc_MEKK1_plant
cd14148560-748  STKc_MLK2
cd05095560-745  PTKc_DDR2
cd13996502-736  STKc_EIF2AK
cd06631518-736  STKc_YSK4
cd14012513-736  PK_eIF2AK_GCN2_rpt1
cd05115497-745  PTKc_Zap-70
cd14064532-746  PKc_TNNI3K
cd08220507-741  STKc_Nek8
cd14160560-674  PK_IRAK3
cd06605526-741  PKc_MAPKK
cd05108597-748  PTKc_EGFR
cd05111597-748  PTK_HER3
cd14158511-748  STKc_IRAK4
cd14046502-736  STKc_EIF2AK4_GCN2_rpt2
cd05097532-745  PTKc_DDR_like
cd05054560-750  PTKc_VEGFR
cd14146528-748  STKc_MLK4
cd14147560-745  STKc_MLK3
cd05117501-736  STKc_CAMK
cd14204594-748  PTKc_Mer
cd08529507-741  STKc_FA2-like
cd13989561-712  STKc_IKK
cd06642517-673  STKc_STK25
cd06628509-736  STKc_Byr2_like
cd14057562-748  PK_ILK
cd13998560-748  STKc_TGFbR-like
cd05043597-755  PTK_Ryk
cd14152522-748  STKc_KSR1
cd14159502-685  STKc_IRAK1
cd05096576-747  PTKc_DDR1
cd05103584-741  PTKc_VEGFR2
cd05102595-750  PTKc_VEGFR3
cd05036540-741  PTKc_ALK_LTK
cd14151530-741  STKc_B-Raf
cd14153515-748  PK_KSR2
cd08225503-680  STKc_Nek5
cd06655528-674  STKc_PAK2
cd14187527-685  STKc_PLK1
cd14052511-673  PTKc_Wee1_fungi
cd14009511-738  STKc_ATG1_ULK_like
cd08215505-741  STKc_Nek
cd06648524-674  STKc_PAK_II
cd06621531-673  PKc_Pek1_like
cd14054508-735  STKc_BMPR2_AMHR2
cd06647524-674  STKc_PAK_I
cd14000560-736  STKc_LRRK
cd05110597-748  PTKc_HER4
cd08222511-736  STKc_Nek11
cd06637523-673  STKc_TNIK
cd14188529-741  STKc_PLK2
cd06607506-677  STKc_TAO
cd06635513-778  STKc_TAO1
cd06633508-684  STKc_TAO3
cd06613513-741  STKc_MAP4K3_like
cd06624510-736  STKc_ASK
cd06654553-674  STKc_PAK1
cd14080532-736  STKc_TSSK-like
cd06656553-674  STKc_PAK3
cd08221530-736  STKc_Nek9
cd05572503-674  STKc_cGK
cd14053507-676  STKc_ACVR2
cd14003510-736  STKc_AMPK-like
cd07863599-695  STKc_CDK4
cd06622547-738  PKc_PBS2_like
cd07843494-694  STKc_CDC2L1
cd06917533-673  STKc_NAK1_like
cd14201521-710  STKc_ULK2
cd14116528-741  STKc_Aurora-A
cd06650532-668  PKc_MEK1
cd14037511-737  STKc_NAK_like
cd07838593-695  STKc_CDK4_6_like
cd05581509-644  STKc_PDK1
cd14206506-746  PTKc_Aatyk3
cd14055563-735  STKc_TGFbR2_like
cd06629511-736  STKc_Bck1_like
cd06649532-673  PKc_MEK2
cd06658507-674  STKc_PAK5
cd06638527-736  STKc_myosinIIIA_N
cd14002528-684  STKc_STK36
cd14038561-674  STKc_IKK_beta
cd14069517-669  STKc_Chk1
cd08217507-737  STKc_Nek2
cd13994560-741  STKc_HAL4_like
cd14011594-742  PK_SCY1_like
cd07833513-737  STKc_CDKL
cd14202521-726  STKc_ULK1
cd07862593-695  STKc_CDK6
cd06620511-677  PKc_Byr1_like
cd14047507-745  STKc_EIF2AK2_PKR
cd13982532-743  STKc_IRE1
cd08218507-741  STKc_Nek1
cd06636527-673  STKc_MAP4K4_6_N
cd14093543-685  STKc_PhKG
cd13975585-748  PKc_Dusty
cd14039561-751  STKc_IKK_alpha
cd14056560-748  STKc_TGFbR_I
cd06630532-736  STKc_MEKK1
cd14068560-736  STKc_LRRK2
cd14185543-735  STKc_DCKL3
cd08528538-746  STKc_Nek10
cd07861578-695  STKc_CDK1_euk
cd06608527-673  STKc_myosinIII_N_like
cd06639527-673  STKc_myosinIIIB_N
cd13968514-634  PKc_like
cd08219507-736  STKc_Nek3
cd13984515-736  PK_NRBP1_like
cd14193527-728  STKc_MLCK4
cd06625528-736  STKc_MEKK3_like
cd07829514-695  STKc_CDK_like
cd06659540-711  STKc_PAK6
cd13990482-737  STKc_TLK
cd06611521-673  STKc_SLK_like
cd13993532-735  STKc_Pat1_like
cd14140543-748  STKc_ACVR2b
cd0638697-397  PBP1_NPR_C_like
cd07853594-680  STKc_NLK
cd08223507-741  STKc_Nek4
cd14048506-674  STKc_EIF2AK3_PERK
cd14049556-679  STKc_EIF2AK1_HRI
cd14095507-669  STKc_DCKL
cd06634513-684  STKc_TAO2
cd14067514-736  STKc_LRRK1
cd14099528-669  STKc_PLK
cd14197543-684  STKc_DRAK1
cd14010539-735  STKc_ULK4
cd14034527-741  PK_NRBP1
cd05578597-690  STKc_Yank1
cd14097544-688  STKc_STK33
cd14192527-669  STKc_MLCK3
cd08228506-737  STKc_Nek6
cd07840506-680  STKc_CDK9_like
cd14072511-741  STKc_MARK
cd14663509-669  STKc_SnRK3
cd05078510-741  PTK_Jak2_rpt1
cd05042508-736  PTKc_Aatyk
cd14098511-736  STKc_Rad53_Cds1
cd06385118-398  PBP1_NPR_A
cd08229532-737  STKc_Nek7
cd13983526-667  STKc_WNK
cd14181539-653  STKc_PhKG2
cd05086512-736  PTKc_Aatyk2
cd14071510-669  STKc_SIK
cd14190531-669  STKc_MLCK2
cd14107544-736  STKc_obscurin_rpt1
cd05619510-735  STKc_nPKC_theta
cd07856594-680  STKc_Sty1_Hog1
cd07845532-680  STKc_CDK10
cd06646541-743  STKc_MAP4K5
cd14120505-738  STKc_ULK1_2-like
cd06619527-675  PKc_MKK5
cd06657540-674  STKc_PAK4
cd14220555-748  STKc_BMPR1a
cd07835592-695  STKc_CDK1_CdkB_like
cd13995543-667  STKc_MAP3K8
cd14079527-669  STKc_AMPK_alpha
cd06644527-736  STKc_STK10
cd06645543-741  STKc_MAP4K3
cd14143555-748  STKc_TGFbR1_ACVR1b_ACVR1c
cd14084507-741  STKc_Chk2
cd13988527-634  STKc_TBK1
cd07855594-680  STKc_ERK5
cd06615547-668  PKc_MEK
cd07872532-695  STKc_PCTAIRE2
cd14117528-696  STKc_Aurora-B_like
cd07841560-695  STKc_CDK7
cd14004592-741  STKc_PASK
cd05087512-746  PTKc_Aatyk1
cd14142554-748  STKc_ACVR1_ALK1
cd08216511-672  PK_STRAD
cd07834594-736  STKc_MAPK
cd14110532-670  STKc_obscurin_rpt2
cd14108532-670  STKc_SPEG_rpt1
cd06653530-677  STKc_MEKK3_like_u1
cd08224505-737  STKc_Nek6_7
cd13981560-652  STKc_Bub1_BubR1
cd06651597-677  STKc_MEKK3
cd05077489-741  PTK_Jak1_rpt1
cd14184532-709  STKc_DCKL2
cd07830592-680  STKc_MAK_like
cd14077597-669  STKc_Kin1_2
cd13985501-748  STKc_GAK_like
cd14121557-692  STKc_ULK3
cd07860592-695  STKc_CDK2_3
cd14050562-668  PKc_Myt1
cd05076512-741  PTK_Tyk2_rpt1
cd08530509-741  STKc_CNK2-like
cd07858594-680  STKc_TEY_MAPK
cd06652532-677  STKc_MEKK2
cd14141528-732  STKc_ACVR2a
cd14162543-669  STKc_TSSK4-like
cd14078530-685  STKc_MELK
cd14198543-736  STKc_DRAK2
cd0626971-287  PBP1_glutamate_receptors_like
cd05580512-692  STKc_PKA_like
cd14167593-735  STKc_CaMKI_alpha
cd05118510-695  STKc_CMGC
cd14186512-692  STKc_PLK4
cd14163532-669  STKc_TSSK3-like
cd05612526-681  STKc_PRKX_like
cd07846532-736  STKc_CDKL2_3
cd06617590-757  PKc_MKK3_6
cd07876585-674  STKc_JNK2
cd14144555-748  STKc_BMPR1
cd14111560-692  STKc_SPEG_rpt2
cd05620510-745  STKc_nPKC_delta
cd06384118-397  PBP1_NPR_B
cd14106560-736  STKc_DRAK
cd07877593-695  STKc_p38alpha
cd05594596-695  STKc_PKB_alpha
cd07849594-680  STKc_ERK1_2_like
cd05123495-690  STKc_AGC
cd07847560-652  STKc_CDKL1_4
cd07850594-680  STKc_JNK
cd14182543-669  STKc_PhKG1
cd07848507-673  STKc_CDKL5
cd07874585-680  STKc_JNK3
cd08226567-736  PK_STRAD_beta
cd14118560-735  STKc_CAMKK
cd14119560-634  STKc_LKB1
cd07857592-680  STKc_MPK1
cd14070512-740  STKc_HUNK
cd07852590-695  STKc_MAPK15-like
cd07880593-680  STKc_p38gamma
cd07842552-737  STKc_CDK8_like
cd14081528-669  STKc_BRSK1_2
cd14219555-748  STKc_BMPR1b
cd07875585-680  STKc_JNK1
cd07865485-634  STKc_CDK9
cd14133592-737  PKc_DYRK_like
cd07879588-722  STKc_p38delta
cd14103528-670  STKc_MLCK
cd07836532-695  STKc_Pho85
cd07867592-735  STKc_CDC2L6
cd05593596-735  STKc_PKB_gamma
cd14085500-681  STKc_CaMKIV
cd07868592-735  STKc_CDK8
cd14137595-634  STKc_GSK3
smart00044788-979  CYCc
pfam0109454-384  ANF_receptor
pfam07714502-745  Pkinase_Tyr
smart00221502-745  STYKc
smart00219516-741  TyrKc
COG2114788-999  AcyC
pfam00069507-741  Pkinase
smart00220507-741  S_TKc
COG0515508-736  SPS1
PHA02988507-741  PHA02988
PLN00113532-677  PLN00113
PTZ00267505-687  PTZ00267
PLN00034560-639  PLN00034
TIGR03903554-672  TOMM_kin_cyc
PTZ00283532-749  PTZ00283
PTZ00263488-735  PTZ00263
PLN00009532-695  PLN00009
PHA03209597-681  PHA03209
PTZ00024560-680  PTZ00024
PTZ00426500-681  PTZ00426


Ontology Information


   
HPRD ID2079
Molecular ClassGuanylate cyclase
Molecular FunctionGrowth factor activity (GO:0008083)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P25092DB08890LinaclotideSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO