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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| HIST1H1C | 3006 | Histone cluster 1, H1c | 6 | H1C; H1.2; H1F2; H1s-1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20089989 | 2010 | Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : - No. of Sample : - Stage : - | Biochemical isolation to nano-LC-MS/MS analysis using spectral counting combined with statistics. | Up-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Histones / Replication-dependent |
| Description | Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Jul 2008] |
| Chromosome | 6 |
| Location | 6p21.3 |
| Start | 26055740 |
| End | 26056471 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 732 |
| OMIM ID | 142710 |
| HGNC ID | HGNC:4716 |
| Unigene ID | Hs.7644 |
| Ensembl ID | ENSG00000187837 |
| PharmGKB ID | - |
Protein Information
| Protein ID | NP_005310.1 |
|---|---|
| Protein Name | Histone cluster 1, H1c |
| Molecular Wt. (Da) | 21234 |
| Protein Sequence | Download Select all |
| Length | 213 |
| Uniprot ID | O60566 |
| Ensembl Protein ID | ENSP00000287598 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Acetylation | 2 |
| T | Phosphorylation | 146 |
| S | Phosphorylation | 173 |
| S | Phosphorylation | 2 |
| K | Acetylation | 17 |
| K | Acetylation | 52 |
| K | Acetylation | 85 |
| K | Acetylation | 97 |
| K | Acetylation | 169 |
| K | Ubiquitination | 46 |
| T | Phosphorylation | 165 |
| K | Acetylation | 90 |
| K | Acetylation | 64 |
| K | Acetylation | 46 |
| S | Phosphorylation | 36 |
| K | Acetylation | 34 |
| K | Methylation | 26 |
| K | Methylation | 34 |
| K | Methylation | 46 |
| S | Phosphorylation | 41 |
| K | Methylation | 63 |
| K | Methylation | 75 |
| T | Phosphorylation | 31;- |
| T | Phosphorylation | 4;- |
| S | Phosphorylation | 104 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 4678 | NASP | 4423 | NP_751896.1 | in vitro | 10893414 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00073 | 34-119 | H15 |
| cl00073 | 34-119 | H15 superfamily |
| pfam00538 | 36-109 | Linker_histone |
| smart00526 | 34-98 | H15 |
Ontology Information
| HPRD ID | 4176 |
|---|---|
| Molecular Class | DNA binding protein |
| Molecular Function | Protein serine/threonine kinase activity (GO:0004674) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.