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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 15526283 | 2005 | Cell line : HT 29, Caco 2 Source : - Sample Type : - No. of Sample : - Stage : - | - | Up-regulation | - | Human colon adenocarcinoma cell differentiation is associated with an up-regulation of AnxA1, AnxA2, and AnxA5 and with a subcellular relocation of these proteins. Up-regulation of AnxA1 could contribute to the reported anti-inflammatory effects of butyrate in colon inflammatory diseases. |
| 18071363 | 2008 | Cell line : - Source : Aberdeen colorectal tumour bank Sample Type : CRC tumor and Normal tissue No. of Sample : 10 pairs of tumour and normal samples Stage : Duke Stage C | 2-D Gelelectrophoresis, MALDITOF MS, Immunohistochemistry | Up-regulation | - | - |
| 19737943 | 2009 | Cell line : - Source : University of Maryland Medical Center or Baltimore Veterans Administration Medical Center, Queen Mary Hospital in Hong Kong. Sample Type : CRC tumor and Normal tissue No. of Sample : 196 Stage : TNM Stage I-IV | real time RT-PCR | Up-regulation | - | - |
| 23567825 | 2013 | Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : - Stage : - | Lectin microarray, lectin histochemistry and nano liquid chromatography-mass spectrometry/mass spectrometry | Up-regulation | - | Annexin A1 and HSP90 were GlcNAcylated, and their protein expressions were elevated in colon cancer, compared to normal tissues. Specific changes of GlcNAc abundances in Annexin A1 and HSP90 suggested that tumor-specific glycan patterns could serve as candidate biomarkers of colon cancer for distinguishing cancer patients from healthy individuals. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Annexins, Endogenous ligands |
| Description | Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity. [provided by RefSeq, Jul 2008] |
| Chromosome | 9 |
| Location | 9q21.13 |
| Start | 73151731 |
| End | 73170393 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 18663 |
| OMIM ID | 151690 |
| HGNC ID | HGNC:533 |
| Unigene ID | Hs.494173 |
| Ensembl ID | ENSG00000135046 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_000700.2 |
|---|---|
| Exon | join(1..194,6792..6871,6965..7073,7599..7693,8533..8646, 9073..9163,11052..11131,11746..11802,13386..13479, 14367..14462,15767..15825,17302..17424,18321..18663) | mRNA Sequence | Download Select all |
| Length | 1399 |
CDS Information
| Location | join(2594..2612,6792..6871,6965..7073,7599..7693, 8533..8646,9073..9163,11052..11131,11746..11802, 13386..13479,14367..14462,15767..15825,17302..17424, 18321..18377) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_000691.1 |
|---|---|
| Protein Name | Annexin A1 |
| Molecular Wt. (Da) | 38583 |
| Protein Sequence | Download Select all |
| Length | 346 |
| Uniprot ID | Q04771 |
| Ensembl Protein ID | ENSP00000263640 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 216 |
| Y | Phosphorylation | 21 |
| S | Phosphorylation | 5 |
| S | Phosphorylation | 27 |
| Y | Phosphorylation | 207;- |
| Y | Phosphorylation | 39;- |
| Y | Phosphorylation | 207;- |
| S | Phosphorylation | 37 |
| S | Phosphorylation | 170 |
| K | Acetylation | 161 |
| K | Acetylation | 312 |
| K | Acetylation | 239 |
| K | Acetylation | 250 |
| K | Acetylation | 281 |
| K | Acetylation | 53 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1956 | EGFR | 579 | NP_005219.2 | in vivo | 15581623 |
| 2357 | FPR1 | 646 | NP_002020.1 | in vitro;in vivo | 10882119 |
| 3856 | KRT8 | 1015 | NP_002264.1 | in vivo | 9459484 |
Pathway Information
No matching records could be found.
Structure Information
| PDB ID | 1AIN |
|---|---|
| Resolution | 2.5 |
| Method | X-RAY DIFFRACTION |
| Chains | A |
| Molecule | ANNEXIN I |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00191 | 118-183 | Annexin |
| cl02574 | 118-183 | Annexin superfamily |
| pfam00191 | 277-342 | Annexin |
| cl02574 | 277-342 | Annexin superfamily |
| smart00335 | 131-183 | ANX |
| pfam00191 | 47-111 | Annexin |
| cl02574 | 47-111 | Annexin superfamily |
| smart00335 | 290-342 | ANX |
| pfam00191 | 202-267 | Annexin |
| cl02574 | 202-267 | Annexin superfamily |
| smart00335 | 59-111 | ANX |
| smart00335 | 215-267 | ANX |
| COG5118 | 13-144 | BDP1 |
Ontology Information
| HPRD ID | 21 |
|---|---|
| Molecular Class | Calcium binding protein |
| Molecular Function | Receptor signaling protein serine/threonine kinase activity (GO:0004702) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P04083 | DB00288 | Amcinonide | SmallMoleculeDrug |
| P04083 | DB00741 | Hydrocortisone | SmallMoleculeDrug |
| P04083 | DB01234 | Dexamethasone | SmallMoleculeDrug |