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General Information
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25862913 | 2015 | Cell line : - Source : - Sample Type : CRC tumor and normal tissues No. of Sample : - Stage : - | Immunohistochemistry | Up-regulation | - | A high p-H2AX expression in CRC tissues is associated with a more malignant cancer behavior |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Histones / Replication-independent |
| Description | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Oct 2015] |
| Chromosome | 11 |
| Location | 11q23.3 |
| Start | 118964580 |
| End | 118966177 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 1598 |
| OMIM ID | 601772 |
| HGNC ID | HGNC:4739 |
| Unigene ID | Hs.477879 |
| Ensembl ID | - |
| PharmGKB ID | PA29116 |
Protein Information
| Protein ID | NP_002096.1 |
|---|---|
| Protein Name | H2A histone family, member X |
| Molecular Wt. (Da) | 15013 |
| Protein Sequence | Download Select all |
| Length | 143 |
| Uniprot ID | P0DJI8 |
| Ensembl Protein ID | ENSP00000348918 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 137 |
| S | Phosphorylation | 2 |
| K | Ubiquitination | 119 |
| S | Phosphorylation | 140 |
| S | Dephosphorylation | 140 |
| S | Phosphorylation | 122 |
| K | Acetylation | 6 |
| K | Acetylation | 10 |
| T | Phosphorylation | 121 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 672 | BRCA1 | 218 | NP_009231.2 | in vivo | 12419185 |
| 4361 | MRE11A | 2889 | NP_005582.1 | in vitro;in vivo | 12419185 |
| 6829 | SUPT5H | 3655 | NP_003160.2 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Alcoholism | hsa05034 |
| Systemic lupus erythematosus | hsa05322 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00074 | 6-120 | H2A |
| cl00074 | 6-120 | H2A superfamily |
| smart00414 | 17-121 | H2A |
| COG5262 | 3-121 | HTA1 |
| PLN00154 | 1-121 | PLN00154 |
| PTZ00252 | 10-131 | PTZ00252 |
| pfam00125 | 18-91 | Histone |
| PLN00155 | Mar-59 | PLN00155 |
| COG5247 | 25-106 | BUR6 |
| COG2036 | Jul-89 | HHT1 |
| pfam00808 | 26-88 | CBFD_NFYB_HMF |
| PTZ00017 | 1-131 | PTZ00017 |
| PLN00157 | 1-127 | PLN00157 |
| PLN00156 | 1-143 | PLN00156 |
| PLN00153 | 3-126 | PLN00153 |
Ontology Information
| HPRD ID | 3647 |
|---|---|
| Molecular Class | DNA binding protein |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.