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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 15065603 | 2004 | Cell line : - Source : - Sample Type : CRC tumor and normal tissues No. of Sample : 32 Stage : Duke Stage A-D | real time RT-PCR | Up-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Glycosyltransferase family 2 domain containing |
| Description | Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1. [provided by RefSeq, Jul 2008] |
| Chromosome | 8 |
| Location | 8q24.12 |
| Start | 122624356 |
| End | 122653675 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 29320 |
| OMIM ID | 601636 |
| HGNC ID | HGNC:4819 |
| Unigene ID | Hs.159226 |
| Ensembl ID | ENSG00000170961 |
| PharmGKB ID | PA29195 |
mRNA Information
| mRNA ID | XM_011517003.1 |
|---|---|
| Exon | join(200..538,24185..24286,26353..29275) | mRNA Sequence | Download Select all |
| Length | 3364 |
Protein Information
| Protein ID | XP_011515305.1 |
|---|---|
| Protein Name | hyaluronan synthase 2 |
| Molecular Wt. (Da) | 38877 |
| Protein Sequence | Download Select all |
| Length | 337 |
| Uniprot ID | Q9UQD0 |
| Ensembl Protein ID | ENSP00000346534 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd06434 | 84-361 | GT2_HAS |
| cl11394 | 84-361 | Glyco_tranf_GTA_type superfamily |
| cd06423 | 89-314 | CESA_like |
| cd04190 | 177-357 | Chitin_synth_C |
| pfam00535 | 88-294 | Glycos_transf_2 |
| cd06439 | 84-341 | CESA_like_1 |
| cd00761 | 89-240 | Glyco_tranf_GTA_type |
| cd06421 | 84-360 | CESA_CelA_like |
| pfam13632 | 207-411 | Glyco_trans_2_3 |
| cd02525 | 84-147 | Succinoglycan_BP_ExoA |
| cd06433 | 97-127 | GT_2_WfgS_like |
| TIGR04242 | 48-463 | nodulat_NodC |
| COG1215 | 34-491 | BcsA |
| pfam03142 | 89-357 | Chitin_synth_2 |
| pfam13641 | 85-357 | Glyco_tranf_2_3 |
| COG1216 | 96-421 | GT2 |
| PRK14583 | 9-397 | hmsR |
| PRK11204 | 42-419 | PRK11204 |
| TIGR03937 | 206-419 | PgaC_IcaA |
| TIGR03111 | 58-395 | glyc2_xrt_Gpos1 |
| COG0463 | 82-127 | WcaA |
Ontology Information
| HPRD ID | 1149 |
|---|---|
| Molecular Class | Enzyme: Glycosyltransferase |
| Molecular Function | Chemokine activity (GO:0008009) |
| Biological Process | Immune response (GO:0006955) |
Drug Information
No matching records could be found.