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General Information
- Evidence
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 16733264 | 2006 | Cell line : - Source : Tissue Bank Network of the CNIO in collaboration with the following hospitals in Spain: Virgen de la Salud (Toledo), Cartagena (Murcia), Puerta de Hierro (Madrid), Clnico de San Carlos (Madrid), Ram?n y Cajal (Madrid), and Alcorcn (Madrid). Sample Type : CRC tumor and Normal tissue No. of Sample : 22 Stage : Duke stage A,B, C | Immunoblotting and tissue microarray analysis | Up-regulation | - | May be used as potent Biomarker. It show overexpression in CRC |
| 19795455 | 2010 | Cell line : - Source : Greater Toronto Area and surrounding region and also in the United States. Sample Type : Blood samples No. of Sample : 314 CRC blood and 228 blood control Stage : TNM Stage I-IV | real time RT-PCR | Up-regulation | 1.67 | Seven genes were selected for the development of our CRC biomarker panel. Six of them (ANXA3, CLEC4D, LMNB1, PRRG4, TNFAIP6 and VNN1) were overexpressed (1.31- to 1.67-fold), and 1 (IL2RB) was underexpressed (0.84-fold) in CRC. |
| 20846378 | 2010 | Cell line : - Source : Lam Wah Ee Hospital, Penang, Malaysia. Sample Type : Blood samples No. of Sample : 210 patients (99 CRC and 111 controls) Stage : - | real time RT-PCR | Up-regulation | 1.71 - 2.06 | ANXA3 can acts as a biomarker for colorectal cancer along with other gene. |
| 23011854 | 2013 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Up-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Annexins |
| Description | This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phopholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation. [provided by RefSeq, Jul 2008] |
| Chromosome | 4 |
| Location | 4q21.21 |
| Start | 78551588 |
| End | 78610451 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 58864 |
| OMIM ID | 106490 |
| HGNC ID | HGNC:541 |
| Unigene ID | Hs.480042 |
| Ensembl ID | ENSG00000138772 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_005139.2 |
|---|---|
| Exon | join(1..272,2849..2901,21593..21680,27440..27534, 30590..30703,34673..34763,39957..40036,43794..43850, 44207..44300,45732..45827,49923..49981,52690..52812, 58469..58864) | mRNA Sequence | Download Select all |
| Length | 1634 |
CDS Information
| Location | join(2887..2901,21593..21680,27440..27534,30590..30703, 34673..34763,39957..40036,43794..43850,44207..44300, 45732..45827,49923..49981,52690..52812,58469..58528) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS3584.1 |
Protein Information
| Protein ID | NP_005130.1 |
|---|---|
| Protein Name | Annexin A3 |
| Molecular Wt. (Da) | 36244 |
| Protein Sequence | Download Select all |
| Length | 323 |
| Uniprot ID | Q03154 |
| Ensembl Protein ID | ENSP00000384296 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 7157 | TP53 | 1859 | NP_000537.3 | yeast 2-hybrid | 16169070 |
| 9094 | UNC119 | 4927 | NP_005139.1 | yeast 2-hybrid | 16169070 |
| 10436 | EMG1 | 12803 | NP_006322.4 | yeast 2-hybrid | 16169070 |
| 84966 | IGSF21 | 11309 | NP_116269.2 | yeast 2-hybrid | 16169070 |
| 197131 | UBR1 | 9342 | NP_777576.1 | yeast 2-hybrid | 16169070 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00191 | 94-159 | Annexin |
| cl02574 | 94-159 | Annexin superfamily |
| pfam00191 | 23-87 | Annexin |
| cl02574 | 23-87 | Annexin superfamily |
| pfam00191 | 255-318 | Annexin |
| cl02574 | 255-318 | Annexin superfamily |
| pfam00191 | 177-243 | Annexin |
| cl02574 | 177-243 | Annexin superfamily |
| smart00335 | 35-87 | ANX |
| smart00335 | 107-159 | ANX |
| smart00335 | 266-316 | ANX |
| smart00335 | 191-243 | ANX |
Ontology Information
| HPRD ID | 92 |
|---|---|
| Molecular Class | Calcium binding protein |
| Molecular Function | Hydrolase activity (GO:0016787) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.