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General Information
- Evidence
- Gene
- mRNA
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- Protein
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- Enzyme
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- Domain
- Ontology
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26296979 | 2015 | Cell line : - Source : Renming Hospital Wuhan University, China. Sample Type : CRC tumor No. of Sample : 176 Stage : - | Cellular proliferation, migration, invasion Assay | Up-regulation | - | HDGF and ?-catenin interacts as a positive feedback loop, which plays an important role in carcinogenesis and progression of CRC.Significant positive correlation between HDGF expression and ?-catenin abnormal expression was found in CRC tissues. |
| 19924574 | 2010 | Cell line : - Source : Department of Pathology, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China Sample Type : CRC tumor No. of Sample : - Stage : - | Immunohistochemistry, flow cytometry, DNA ladder analysis, and Hoechst 33258 staining,Western Blotting, real time RT-PCR. | Unknown | - | HDGF might be a potential therapeutic target for human colorectal cancer. These findings may have major implications in the treatment of colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the hepatoma-derived growth factor family. The encoded protein has mitogenic and DNA-binding activity and may play a role in cellular proliferation and differentiation. High levels of expression of this gene enhance the growth of many tumors. This gene was thought initially to be located on chromosome X; however, that location has been determined to correspond to a related pseudogene. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2016] |
| Chromosome | 1 |
| Location | 1q23.1 |
| Start | 156711899 |
| End | 156722240 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 10342 |
| OMIM ID | 600339 |
| HGNC ID | HGNC:4856 |
| Unigene ID | Hs.743948 |
| Ensembl ID | ENSG00000143321 |
| PharmGKB ID | PA29234 |
mRNA Information
| mRNA ID | NM_001126050.1 |
|---|---|
| Exon | join(1..220,7076..7152,7303..7441,8101..8286,8571..8797, 8994..10342) | mRNA Sequence | Download Select all |
| Length | 2208 |
Protein Information
| Protein ID | NP_001119522.1 |
|---|---|
| Protein Name | hepatoma-derived growth factor |
| Molecular Wt. (Da) | 28133 |
| Protein Sequence | Download Select all |
| Length | 256 |
| Uniprot ID | P13501 |
| Ensembl Protein ID | ENSP00000474412 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 132 |
| S | Phosphorylation | 133 |
| S | Phosphorylation | 165 |
| T | Phosphorylation | 200 |
| S | Phosphorylation | 202 |
| S | Phosphorylation | 206 |
| S | Phosphorylation | 165;- |
| S | Phosphorylation | 239 |
| S | Phosphorylation | 107 |
| K | Acetylation | 44 |
| S | Phosphorylation | 199 |
| S | Phosphorylation | 103 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 4089 | SMAD4 | 2995 | NP_005350.1 | in vivo | 15761153 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd05834 | Aug-92 | HDGF_related |
| cl02554 | Aug-92 | PWWP superfamily |
| cd05162 | Oct-91 | PWWP |
| pfam00855 | Oct-91 | PWWP |
| smart00293 | Oct-67 | PWWP |
| cd05836 | Oct-91 | N_Pac_NP60 |
| cd05841 | 15-90 | BS69_related |
| cd05840 | Oct-80 | SPBC215_ISWI_like |
| cd05837 | Sep-81 | MSH6_like |
| cd05835 | 13-80 | Dnmt3b_related |
| cd05838 | 13-88 | WHSC1_related |
| cd06080 | Oct-80 | MUM1_like |
| cd05839 | Oct-80 | BR140_related |
Ontology Information
| HPRD ID | 1150 |
|---|---|
| Molecular Class | Growth factor |
| Molecular Function | Chemokine activity (GO:0008009) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.