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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
HGF 3082 hepatocyte growth factor (hepapoietin A; scatter factor)  7SF, F-TCF, HGFB, HPTA 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21447729   2011Cell line : -

Source : IRCC, Ordine Mauriziano, and San Giovanni Battista Hospitals (Torino, Italy).

Sample Type : CRC Tumor and adjecent normal tissue

No. of Sample : 103

Stage : Stage I,II, III

PCR, In silico analysis,Gene copy number and expression analysisAmplification-High-grade amplifications of MET, MACC1, or HGF were detected.

23532910   2013Cell line : -

Source : Shandong Cancer Hospital.

Sample Type : CRC Tumor

No. of Sample : 253

Stage : -

 Immunohistochemistry, real time RT-PCRUp-regulation-Synchronous liver metastasis (SLM) remains a significant problem in newly diagnosed colorectal cancer (CRC).HGF and Met may exert functions in the development of SLM when concurrent with lymph node metastases.Expression of HGF and Met at the protein level and the RNA level in primary CRCs with SLM were significantly higher than that in primary colorectal carcinomas without liver metastases.

24953371   2014Cell line : -

Source : -

Sample Type : CRC Tumor

No. of Sample : 30

Stage : TNM stage I,II,III,IV

ImmunohistochemistryUp-regulation-HGF-c-Met may play a role in colorectal cancer patients with synchronous liver metastasis.


Gene Details



NC_000007.13 (81331444..81399452, complement)

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Gene Type protein coding
Gene Family -
Description This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss. [provided by RefSeq, Nov 2015]  
Chromosome 7
Location 7q21.1
Start 81331444  
End 81399452  
Strand -  
Gene Sequence

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Length 68009  
OMIM ID 142409   
HGNC ID HGNC:4893   
Unigene ID Hs.396530   
Ensembl ID ENSG00000019991   
PharmGKB ID PA29269   

mRNA Information


mRNA ID XM_011516115.1
Exon join(1..148,426..555,7567..7732,11635..11747,13136..13250, 18192..18319,25319..25439,26968..27086,40660..40834, 44422..44549,49592..49694,53074..53207,58920..58958, 60196..60292,63075..63149,64012..64152,64686..64792, 64904..65049,67682..71433)  
mRNA Sequence

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Length 5937  



CDS Information


   
Location 191..2362
CDS Sequence

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CCDS ID CCDS47626.1



Protein Information


      
Protein ID XP_011514417.1
Protein Namehepatocyte growth factor (hepapoietin A; scatter factor)
Molecular Wt. (Da)82471
Protein Sequence

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Length 723  
Uniprot IDP55774
Ensembl Protein ID ENSP00000483144  



Post-translational Modification Information (Source : HPRD)


Residue Type site
RProteolytic Cleavage494
RProteolytic Cleavage489
RProteolytic Cleavage494
RProteolytic Cleavage489
RProteolytic Cleavage494
RProteolytic Cleavage489
RProteolytic Cleavage424
RProteolytic Cleavage424
RProteolytic Cleavage419
RProteolytic Cleavage419

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                            
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
3249HPN801NP_892028.1in vitro15792801   
3934LCN22551NP_005555.2in vitro15637066   
5328PLAU1883NP_002649.1in vitro1334458   
7448VTN1902NP_000629.3in vitro15717924   


Pathway Information


                                                            
Pathway Name Pathway ID
Cytokine-cytokine receptor interaction hsa04060
Focal adhesion hsa04510
Malaria hsa05144
Melanoma hsa05218
Pathways in cancer hsa05200
PI3K-Akt signaling pathway hsa04151
Proteoglycans in cancer hsa05205
Rap1 signaling pathway hsa04015
Ras signaling pathway hsa04014
Renal cell carcinoma hsa05211


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00190495-719  Tryp_SPc
cl21584495-719  Tryp_SPc superfamily
cd00108208-289  KR
cl00100208-289  KR superfamily
cd00108126-207  KR
cl00100126-207  KR superfamily
cd00108302-384  KR
cl00100302-384  KR superfamily
cd00108388-470  KR
cl00100388-470  KR superfamily
cd0012939-122  PAN_APPLE
cl0011239-122  PAN_APPLE superfamily
smart00130210-290  KR
pfam00051211-288  Kringle
smart00130126-208  KR
smart00130304-384  KR
pfam00051305-383  Kringle
smart00130389-471  KR
pfam00051128-206  Kringle
pfam00051391-469  Kringle
cd0109940-122  PAN_AP_HGF
smart0047337-122  PAN_AP
pfam0002441-121  PAN_1
cd0110059-97  APPLE_Factor_XI_like
smart00020494-716  Tryp_SPc
pfam00089495-716  Trypsin
COG5640494-727  COG5640


Ontology Information


   
HPRD ID3750
Molecular ClassGrowth factor
Molecular FunctionCytokine activity (GO:0005125)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO