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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| HINT1 | 3094 | histidine triad nucleotide binding protein 1 | 5 | PKCI-1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17510397 | 2007 | Cell line : SW480, Caco2, HCT116, HT29, SW837, HCT15, NCI-H522 NSCLC,HEK 293, NIH3T3 Source : ATCC Sample Type : - No. of Sample : - Stage : - | Methylation-Specific PCR,Luciferase Reporter Assays,Immunoprecipitation | Methylation | - | HINT1 inhibits AP-1 activity by binding to a POSH-JNK2 complex, thus inhibiting the phosphorylation of c-Jun. This effect could contribute to the tumor suppressor activity of HINT1. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a protein that hydrolyzes purine nucleotide phosphoramidates substrates, including AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester, and AMP-NH2. The encoded protein interacts with these substrates via a histidine triad motif. This gene is considered a tumor suppressor gene. In addition, mutations in this gene can cause autosomal recessive neuromyotonia and axonal neuropathy. There are several related pseudogenes on chromosome 7. Several transcript variants have been observed. [provided by RefSeq, Dec 2015] |
| Chromosome | 5 |
| Location | 5q31.2 |
| Start | 130494976 |
| End | 130501041 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 6066 |
| OMIM ID | 601314 |
| HGNC ID | HGNC:4912 |
| Unigene ID | Hs.483305 |
| Ensembl ID | ENSG00000169567 |
| PharmGKB ID | PA29286 |
mRNA Information
| mRNA ID | XM_011516115.1 |
|---|---|
| Exon | join(1..148,426..555,7567..7732,11635..11747,13136..13250, 18192..18319,25319..25439,26968..27086,40660..40834, 44422..44549,49592..49694,53074..53207,58920..58958, 60196..60292,63075..63149,64012..64152,64686..64792, 64904..65049,67682..71433) | mRNA Sequence | Download Select all |
| Length | 5937 |
Protein Information
| Protein ID | XP_011514417.1 |
|---|---|
| Protein Name | histidine triad nucleotide binding protein 1 |
| Molecular Wt. (Da) | 82471 |
| Protein Sequence | Download Select all |
| Length | 723 |
| Uniprot ID | Q99731 |
| Ensembl Protein ID | ENSP00000308815 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| K | Acetylation | 21 |
| K | Acetylation | 30 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01276 | 16-118 | PKCI_related |
| cl00228 | 16-118 | HIT_like superfamily |
| pfam01230 | 24-121 | HIT |
| pfam11969 | 16-122 | DcpS_C |
| COG0537 | 16-126 | Hit |
| PRK10687 | 16-121 | PRK10687 |
| cd00468 | 32-117 | HIT_like |
| cd01277 | 16-115 | HINT_subgroup |
| cd01278 | 23-116 | aprataxin_related |
| cd01275 | 18-116 | FHIT |
Ontology Information
| HPRD ID | 3571 |
|---|---|
| Molecular Class | ATPase |
| Molecular Function | Chemokine activity (GO:0008009) |
| Biological Process | Immune response (GO:0006955) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P49773 | DB00131 | Adenosine monophosphate | SmallMoleculeDrug |