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General Information
- Evidence
- Gene
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- Protein
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- Enzyme
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 18097579 | 2008 | Cell line : SW480 Source : - Sample Type : CRC tumor and normal tissues No. of Sample : - Stage : - | Bioinformatics tools | Up-regulation | - | This study demonstrates that the glycolytic pathway and glycolysis-related genes may play an important role in the tumorigenesis of CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus; the remainder of the protein is identical among all the isoforms. A sixth transcript variant has been described, but due to the presence of several stop codons, it is not thought to encode a protein. [provided by RefSeq, Apr 2009] |
| Chromosome | 10 |
| Location | 10q22 |
| Start | 71029740 |
| End | 71161638 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 131899 |
| OMIM ID | 142600 |
| HGNC ID | HGNC:4922 |
| Unigene ID | Hs.370365 |
| Ensembl ID | ENSG00000156515 |
| PharmGKB ID | PA29300 |
mRNA Information
| mRNA ID | XM_005269736.1 |
|---|---|
| Exon | join(1..125,18688..18787,25650..25697,73844..74006, 89914..90062,94800..94919,98553..98648,99254..99353, 99458..99641,106951..107106,109879..110112,112504..112808, 114350..114498,114813..114932,116340..116435, 119214..119313,122142..122325,124967..125122, 128612..128845,131008..131899) | mRNA Sequence | Download Select all |
| Length | 3711 |
Protein Information
| Protein ID | XP_005269793.1 |
|---|---|
| Protein Name | hexokinase 1 |
| Molecular Wt. (Da) | 102608 |
| Protein Sequence | Download Select all |
| Length | 921 |
| Uniprot ID | P78556 |
| Ensembl Protein ID | ENSP00000351671 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 305 |
| Y | Phosphorylation | 301 |
| Y | Phosphorylation | 300 |
| Y | Phosphorylation | 289 |
| Y | Phosphorylation | 305 |
| S | Phosphorylation | 302 |
| S | Phosphorylation | 298 |
| S | Phosphorylation | 297 |
| S | Phosphorylation | 286 |
| S | Phosphorylation | 302 |
| S | Phosphorylation | 36 |
| S | Phosphorylation | 32 |
| S | Phosphorylation | 31 |
| S | Phosphorylation | 20 |
| S | Phosphorylation | 36 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 22955 | SCMH1 | 11540 | AAH09752.1 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Amino sugar and nucleotide sugar metabolism | hsa00520 |
| Butirosin and neomycin biosynthesis | hsa00524 |
| Carbohydrate digestion and absorption | hsa04973 |
| Carbon metabolism | hsa01200 |
| Central carbon metabolism in cancer | hsa05230 |
| Fructose and mannose metabolism | hsa00051 |
| Galactose metabolism | hsa00052 |
| Glycolysis / Gluconeogenesis | hsa00010 |
| HIF-1 signaling pathway | hsa04066 |
| Insulin signaling pathway | hsa04910 |
| Metabolic pathways | hsa01100 |
| Starch and sucrose metabolism | hsa00500 |
| Type II diabetes mellitus | hsa04930 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00012 | 529-692 | NBD_sugar-kinase_HSP70_actin |
| cl17037 | 529-692 | NBD_sugar-kinase_HSP70_actin superfamily |
| cd00012 | 81-262 | NBD_sugar-kinase_HSP70_actin |
| cl17037 | 81-262 | NBD_sugar-kinase_HSP70_actin superfamily |
| pfam03727 | 672-907 | Hexokinase_2 |
| cl08402 | 672-907 | Hexokinase_2 superfamily |
| pfam03727 | 223-460 | Hexokinase_2 |
| cl08402 | 223-460 | Hexokinase_2 superfamily |
| pfam00349 | 465-669 | Hexokinase_1 |
| pfam00349 | 17-221 | Hexokinase_1 |
| PTZ00107 | 12-460 | PTZ00107 |
| PTZ00107 | 462-907 | PTZ00107 |
| COG5026 | 468-907 | COG5026 |
| PLN02914 | 28-458 | PLN02914 |
| PLN02914 | 484-906 | PLN02914 |
| COG5026 | 34-460 | COG5026 |
| PLN02405 | 484-906 | PLN02405 |
| PLN02362 | 484-906 | PLN02362 |
| PLN02405 | 38-458 | PLN02405 |
| PLN02362 | 46-458 | PLN02362 |
| PLN02596 | 58-458 | PLN02596 |
| PLN02596 | 484-908 | PLN02596 |
Ontology Information
| HPRD ID | 4113 |
|---|---|
| Molecular Class | Enzyme: Sugar phosphotransferase |
| Molecular Function | Chemokine activity (GO:0008009) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.