CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
HMGB1	3146	High-mobility group box 1	13	HMG1; HMG3; SBP-1

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
20089989	2010	Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tumor and control tissue No. of Sample : - Stage : -	Biochemical isolation to nano-LC-MS/MS analysis and using spectral counting combined with statistics	Down-regulation	-	This genes are differenitially expressed between colorectal adenoma and Colorectal cancer tissue. CRC tissue was collected at the VU University Medical Center, Amsterdam, The Netherlands.
23047645	2013	Cell line : - Source : - Sample Type : - No. of Sample : - Stage : -	-	Up-regulation	-	HMGB1 is a valuable serum biomarker for early estimation of therapy response and prognosis in colorectal cancer patients with liver metastases undergoing RE therapy. Sample size: 49 consecutive colorectal cancer patients with extensive hepatic metastases.

Gene Details

Chromosome: 13; NC_000013.10 (31032877..31040081, complement)
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Gene Type	protein coding
Gene Family	High-mobility group / Canonical
Description	-
Chromosome	13
Location	13q12
Start	30458740
End	30465944
Strand	-
Gene Sequence	>gi\|568815585:c30465944-30458740 Homo sapiens chromosome 13, GRCh38.p2 Primary Assembly TGGAGAGTAATGTTACAGAGCGGAGAGAGTGAGGAGGCTGCGTCTGGCTCCCGCTCTCACAGCCATTGCA GTACATTGAGCTCCATAGAGACAGCACCGGGGCAAGTGAGAGCCGGACGGGCACTGGGCGACTCTGTGCC TCGCTGAGGGTGAGTCTGGGGCAGCGCCGCGGCGGGGAGAGCGCCTCCGGCAGCTCCCCAGCCCGCGCGG CGGCCGGATCCCCGCGGCCGGGAGCCGGCGGGTCAGGATCCACACAAAGGCAAATGAGGGGGGACCGTGG GGGGAACTGCGCACGGAGCGAGCCTCTGCCCGGGCGCCGGGAACGCTGCCCCGCGCCGGTGCCCCGGCCC TCAGGCAGCCTGAGGCGCCGGGAGCCCCGCGCCCCGCGAGTTTCCACCCCCGGCGGCGTCCGCGCTGACT GGCGCAAAAAAAAAAATTTTTTTTTTAATTAAAAAAATTTTGAACGTGTTTTGGGCCCTCGGGCCGGGCG TTCGGGCGGGCGGCGTGCGCGGAGCGCGGCCGGGGCGGCGGGGCCGGCGCGGCTCGGCGGCGGCGGCGGG AGGGCAGCGGCGGCGCTTCCCCGGGCTGCATTGGCCGCCGCCGCAGCGAGCCGGGCGCTGGCGGGGAGCG CGGCCAGCCGGGCGGGCGGCGGGGCGGGCGGGGCGCCGCGGCGGGCGAGGGCGGCGCGGGGGCCTGGGGG CGGCAGTGCGGGCCCGGCCGGCCTCGGCCCGGTCGCGGCGGCGGCGGCGGCCGGGCGGCGGGGGGAGCGG CGCCGCTGCGCTCGCTGGAACATGGCTGACTCGGGCCCGGCGCTGCTGGCTGGAGAGAAAACAAGGCGGG CGGGCGGGGGAGCTGGGCGCAGCAGTTCCGAGGCAACTTTTTTTTTCCTCTCTCTTTTCACAGCCCCGCG TTCTCCGTGCGGGGGCGGCGGGGCGCGCGGCCCGCGCGGAGGGAGACGGGGAGTGGCGGGCGGGTGGGCC CTCGGGCGGCCCCCACCGCGGCGGGGGGAGGGGAGCGGCGCGGAGGGGAGGGCCCGGCCGCGCGCCCCCC GCCCCTCCCCCGGCCGTAATGGCCGAGTGTGTGCGCCAGAGCGCGGCTCGCACCCCGCCCGCCGCCGCCG CCGCGCCCGCACCCTCGCACTCACACACTCTCTCATACACACACACACACACACACACACACAAAGGGAA GGAGCCATATTCTCGCTCGCGCTCGCCCTCGCGGCGGCGGCGGCGCAGGCGGAGAAGACGCGCAGCGGCC ATTCCGTGCGCGCCGGCCCCGGCGGCCGCGGGCGGAGCCAGCCCCCATTTCGAGCGGGGCTTCTCCCTGC GCCGAGCCTGACAAAATGGGGGCGGCGGCGGCGCGGGCCTGCAGGGCCTGCCGGGCGCACGTGGCGGCCT CGGGCCTGGGAGCCGGGCCGCGTCCTCTCTCCTCGGCCGCGCGGCCACCGGCGAAGTTCTAGGGGCGGGG GGCTCGCCCCGCGCAGGAGTCACCCCAACTTTCACGGCTCCAAAAAATACTTCCCGAGTTGGGGGAGGGG GCCACCGAGCCACGAGCAGGAGTGGCTTTTGTCCCTCATCCTTGTTTACTCGGAGAAACTTCAGACCGGA CGTGTTTAGTCAGAACAGAAATACATCTCAGGGCCAAACCGATAGGAAACGAGGCTGCCTCGCGGTGGCA CCGCCACCCCCCAACCGGGTTCCGAGCACCGGAGCTGGCTGCTGCTCCCTCTTTGGAGCAAAGTTTTATG CAAAGAGGGTGTTTTTTGAAACTTTCGGTGCACGGTGATTTTTTTTTTTTAAGGTCCCATAATTAGGAAG AGTCGACTCGCTTAGGCCCTTGTTTATTCCCTATCTAGTGCAAAGCCACGAATTGGCAGCATGTTTTCTG ACCTTTGGTTTGGTTGGTTTAAAATGGTGTTCTAGATTTTAAAATCGTTTAAGTGACCAGTTAGATACTC ATTCAGAGCAGACTCGGGCGGATAGATAGGGAATACTGTATGGGTATATCTTTGTGTCTAGACTTTTTGA GATCGCCCTGAAGGACTGTTTTTGTTTTGTTTTGTTTGCTTGGCATAGCCCCTTCAAGGAATTTAATCTC TCGGCCATATTCTTGTCTGATTTTACGGAGGTTGATGTCGCTACTGTGTTAAATAACCAGTACTTTGGTT TTCATTCCCTTACTAAGTACTTTAAGGTCTTATATGTCATAATTTTATTGCTAACATCAAATATTTATTT TATTTTTTAGAAAAATAACTAAACATGGGCAAAGGAGATCCTAAGAAGCCGAGAGGCAAAATGTCATCAT ATGCATTTTTTGTGCAAACTTGTCGGGAGGAGCATAAGAAGAAGCACCCAGATGCTTCAGTCAACTTCTC AGAGTTTTCTAAGAAGTGCTCAGAGAGGTGGAAGGTAAGAGGGCTTAAAACATGCTAACAAGGTAATTAA AAGACAGTTTCCAATTGAGGATGCAAAAAAAAGCCTAGTTGGCATTCTCGTAGTGGGACGCTATTACATA GCAAAAGACATTGGTTTTGAGGATAATTTACTTAAATGTTACAACTTAAACTTACAAATAATTATTTTGT AGACCATGTCTGCTAAAGAGAAAGGAAAATTTGAAGATATGGCAAAAGCGGACAAGGCCCGTTATGAAAG AGAAATGAAAACCTATATCCCTCCCAAAGGGGAGACAAAAAAGAAGTTCAAGGATCCCAATGCACCCAAG AGGCCTCCGTGAGTATCTTGCCTGTTTTTACTTCCCAGACACGTTTTACAGTAGAATCTGAGAGAAATTT AGCAAGCTACTTTGTCAGTTTAGAGTGTAAATGTACAATCAAAGTTTCTTAGCTAATACTTGTTCATATT GGTTATATTTAAATAGTATAAAATTCCTGTTGGGTGGGAGTGTTCCCAGAGCATTTGAATTAGACATTTG GTCTCCTTTGCCCAGTGTATCTCCTTTTGATCTTTTTATTTCTTGAAAAATACTATCCCTTTGAAATAGT GTAATTGTAGAATGTTCATCTAGGGTTCTAGCTAGTATAAATTAAATAGTTGTAAATTAAGCTTTGGTTG TGAAGGATATTTAGTATATTATAGTATTTGCACCCTGTCCAATGCATCACAGAAATTCACAGGCAGCTTT AAATAGCAATGCAGTGTACACTTGATAGTATTTGTTTTTGTGATCTGTTAACTTAAAATCCTAAAATTAA TTTTTTTTTTAGTTCGGCCTTCTTCCTCTTCTGCTCTGAGTATCGCCCAAAAATCAAAGGAGAACATCCT GGCCTGTCCATTGGTGATGTTGCGAAGAAACTGGGAGAGATGTGGAATAACACTGCTGCAGATGACAAGC AGCCTTATGAAAAGAAGGCTGCGAAGCTGAAGGAAAAATATGAAAAGGTAAGAAGTGTGGGTTTGCTTGG TAAAATGATGACAAGTACGCCAGATGTATGATTGTACTTAGTTTGAGGTGTAATAAGTTTTTAGGGTAAC AGCTACATTAAGTATGGTGTTGATATAAGTCCTCATCCTTCAAAGAATGCAGAGGACCAAATAAATTAGG GTTTTTTTGACTAAAATGTAATCAGACTCAGACAAAGGCTGTGTACATTTATGTTGGTTTTGTTATTCCC CAGTATCTTGAAGTTCATGAAAATGTTGGTAGTCACTTCAAGTCAAAAATGAGCATTTTCAAATGGCTTG GCATACAGTACAAAAACAGGCTAGACAAAGTAATATAGGCTATATTTTTCTTAGTCATATCCTGAAACAT TTATGTTCTTTTCCTTTAGATACTCAAAAAACCACAGCATCACTAAGTTAAATTACAAGTCTGCTGCTCT GTCCAGTAAATTAATAAGATTAAGGAAATCTATAACTCTTATAGTTCAGTAAATTGAAATATTAAATACT TAATTTTCAGCTTTAGTCATTCTGAAAAGTGTTTATTTCTAGATGTTTCTTAACCTAATTGCATGTTTAT TGACAAATTACCTTTTTTTTTTAAGACCACATTTCCTACTAAGGATTAAGGTCTGACAGTGTAAACCTGT AGAGTGCTTTTTTGCATTCAGAAGGTGGCAGTGTCTACCCTTTAATCAAAGTCTCTACATTCTGGTTTTA ATAGAGTTAGGATGTGGTACATAATTGCACCTCAATGAGGCATAACTTTGCAAATATTAGACTATGCCAT TTCATGAGTTATAGATTGTTATAATGATCTTGTATTTTTATGTTCATTTATTGAAGTTCTAGTTATTTCT GGAGTTGCTGTGGATCTACAGATACGTGATATTTTGGTATAACTAGAATCTTGATTTCTTTCATAAAGTT CTGCCATGTTCTATTTCTTTCCTTAATGTTTTTTTCTTCCCTACTGTTTTATCCTCCCTTTGCTTTGGAA GGATATTGCTGCATATCGAGCTAAAGGAAAGCCTGATGCAGCAAAAAAGGGAGTTGTCAAGGCTGAAAAA AGCAAGAAAAAGAAGGAAGAGGAGGAAGATGAGGAAGATGAAGAGGATGAGGAGGAGGAGGAAGATGAAG AAGATGAAGATGAAGAAGAAGATGATGATGATGAATAAGTTGGTTCTAGCGCAGTTTTTTTTTTCTTGTC TATAAAGCATTTAACCCCCCTGTACACAACTCACTCCTTTTAAAGAAAAAAATTGAAATGTAAGGCTGTG TAAGATTTGTTTTTAAACTGTACAGTGTCTTTTTTTGTATAGTTAACACACTACCGAATGTGTCTTTAGA TAGCCCTGTCCTGGTGGTATTTTCAATAGCCACTAACCTTGCCTGGTACAGTATGGGGGTTGTAAATTGG CATGGAAATTTAAAGCAGGTTCTTGTTGGTGCACAGCACAAATTAGTTATATATGGGGATGGTAGTTTTT TCATCTTCAGTTGTCTCTGATGCAGCTTATACGAAATAATTGTTGTTCTGTTAACTGAATACCACTCTGT AATTGCAAAAAAAAAAAAAAAGTTGCAGCTGTTTTGTTGACATTCTGAATGCTTCTAAGTAAATACAATT TTTTTTATTAGTATTGTTGTCCTTTTCATAGGTCTGAAATTTTTCTTCTTGAGGGGAAGCTAGTCTTTTG CTTTTGCCCATTTTGAATCACATGAATTATTACAGTGTTTATCCTTTCATATAGTTAGCTAATAAAAAGC TTTTGTCTACACACCCTGCATATCATAATGGGGGTAAAGTTAAGTTGAGATAGTTTTCATCCATAACTGA ACATCCAAAATCTTGATCAGTTAAGAAATTTCACATAGCCCACTTACATTTACAAACTGAAGAGTAATCA ATCTACTCAAAGCATGGGATTATTAGAATCAAACATTTTGAAAGTCTGTCCTTGAAGGACTAATAGAAAA GTATGTTCTAACCTTTACATGAGGACTCTATTCTTTAACTCCCATTACCATGTAATGGCAGTTATATTTT GCAGTTCCCACATTAAAGAAGACCTGAGAATGTATCCCCAAAAGCGTGAGCTTAAAATACAAGACTGCCA TATTAAATTTTTTGTTGACATTAGTCTCAGTGAAGACTATGAAAATGCTGGCTATAGATGTCTTTTCCCA TTTATCTAAATATGGACTGCTCAGGAAACGAGACTTTCCATTACAAGTATTTTTAATTAATTGGGCCAGC TTTTCAAACAAAGATGCCACATTCAAAATAGGGTATATTTTCCTATATTACGGTTTGCCCCTTTATAAAT CCAAGTAGATAGGAAGAAAGAAGACAAACTTTGCATCTCAGTATGAATTATTCAATTTATTTGAATGATT TTTCTTTACAAAACAAACTCATTCATTAGTCATGTTTATCTGCTTAGGAGTTTAGGGAACAATTTGGCAA TTTTGTGGTTTTCGAGATTATCGTTTTCTTAAAGTGCCAGTATTTTAAAATAGCGTTCTTGTAATTTTAC ACGCTTTTGTGATGGAGTGCTGTTTTGTTATATAATTTAGACTTGGATTCTTTCCATTTGCATTTGTTTA TGTAATTTCAGGAGGAATACTGAACATCTGAGTCCTGGATGATACTAATAAACTAATAATTGCAGAGGTT TTAAATACTAGTTAAATGGCTTTCACTTAAGAACTTAAGATTTTGTTACATATTTTTAAATCTTGTTTCT AATAATACCTCTTAGCAGTACCTTTTAAATAAGTATAAGGGATGGCAAAGTTTTTCCCTTTAAAAATACT CACTTTATGCTTATAAATAGGTTAATGGGCTGATAAAAGGTTTTGTCAAACATTGCAAGTATTCGGTGCT ATATATAAAGGAGGAAAAACTAGTTTTACTTTCAGAATGATTTAAACAAGATTTTTAAAAACAAGATACA TGCAAGCGAACAGCAGGGTTAGTGATAGGCTGCAATTGTGTCGAACATCAGATTTTTTGTTAAGAGGAGC AAATGACTCAATCTGATTTAGATGGAAGTTTCTACTGTATAGAAATCACCATTAATCACCAACATTAATA ATTCTGATCCATTTAAAATGAATTCTGGCTCAAGGAGAATTTGTAACTTTAGTAGGTACGTCATGACAAC TACCATTTTTTTAAGATGTTGAGAATGGGAACAGTTTTTTTAGGGTTTATTCTTGACCACAGATCTTAAG AAAATGGACAAAACCCCTCTTCAATCTGAAGATTAGTATGGTTTGGTGTTCTAACAGTATCCCCTAGAAG TTGGATGTCTAAAACTCAAGTAAATGGAAGTGGGAGGCAATTTAGATAAGTGTAAAGCCTTGTAACTGAA GATGATTTTTTTTAGAAAGTGTATAGAAACTATTTTAATGCCAAGATAGTTACAGTGCTGTGGGGTTTAA AGACTTTGTTGACATCAAGAAAAGACTAAATCTATAATTAATTGGGCCAACTTTTAAAATGAAGATGCTT TTTAAAACTAATGAACTAAGATGTATAAATCTTAGTTTTTTTGTATTTTAAAGATAGGCATATGGCATAT TGATTAACGAGTCAAATTTCCTAACTTTGCTGTGCAAAGGTTGAGAGCTATTGCTGATTAGTTACCACAG TTCTGATGATCGTCCCATCACAGTGTTGTTAATGTTTGCTGTATTTATTAATTTTCTTAAAGTGAAATCT GAAAAATGAAATTTGTGTGTCCTGTGTACCCGAGGGGTAATGATTAAATGATAAAGATAAGAAAA Download Select all
Length	7205
OMIM ID	163905
HGNC ID	HGNC:4983
Unigene ID	Hs.434102
Ensembl ID	ENSG00000189403
PharmGKB ID	PA188

mRNA Information

mRNA ID	NM_002128.4
Exon	join(1..149,2251..2414,2593..2738,3233..3407,4412..7205)
mRNA Sequence	>3146 TGGAGAGTAATGTTACAGAGCGGAGAGAGTGAGGAGGCTGCGTCTGGCTCCCGCTCTCACAGCC ATTGCAGTACATTGAGCTCCATAGAGACAGCGCCGGGGCAAGTGAGAGCCGGACGGGCACTGGG CGACTCTGTGCCTCGCTGAGGAAAAATAACTAAACATGGGCAAAGGAGATCCTAAGAAGCCGAG AGGCAAAATGTCATCATATGCATTTTTTGTGCAAACTTGTCGGGAGGAGCATAAGAAGAAGCAC CCAGATGCTTCAGTCAACTTCTCAGAGTTTTCTAAGAAGTGCTCAGAGAGGTGGAAGACCATGT CTGCTAAAGAGAAAGGAAAATTTGAAGATATGGCAAAAGCGGACAAGGCCCGTTATGAAAGAGA AATGAAAACCTATATCCCTCCCAAAGGGGAGACAAAAAAGAAGTTCAAGGATCCCAATGCACCC AAGAGGCCTCCTTCGGCCTTCTTCCTCTTCTGCTCTGAGTATCGCCCAAAAATCAAAGGAGAAC ATCCTGGCCTGTCCATTGGTGATGTTGCGAAGAAACTGGGAGAGATGTGGAATAACACTGCTGC AGATGACAAGCAGCCTTATGAAAAGAAGGCTGCGAAGCTGAAGGAAAAATACGAAAAGGATATT GCTGCATATCGAGCTAAAGGAAAGCCTGATGCAGCAAAAAAGGGAGTTGTCAAGGCTGAAAAAA GCAAGAAAAAGAAGGAAGAGGAGGAAGATGAGGAAGATGAAGAGGATGAGGAGGAGGAGGAAGA TGAAGAAGATGAAGATGAAGAAGAAGATGATGATGATGAATAAGTTGGTTCTAGCGCAGTTTTT TTTTTCTTGTCTATAAAGCATTTAACCCCCCTGTACACAACTCACTCCTTTTAAAGAAAAAAAT TGAAATGTAAGGCTGTGTAAGATTTGTTTTTAAACTGTACAGTGTCTTTTTTTGTATAGTTAAC ACACTACCGAATGTGTCTTTAGATAGCCCTGTCCTGGTGGTATTTTCAATAGCCACTAACCTTG CCTGGTACAGTATGGGGGTTGTAAATTGGCATGGAAATTTAAAGCAGGTTCTTGTTGGTGCACA GCACAAATTAGTTATATATGGGGATGGTAGTTTTTTCATCTTCAGTTGTCTCTGATGCAGCTTA TACGAAATAATTGTTGTTCTGTTAACTGAATACCACTCTGTAATTGCAAAAAAAAAAAAAAAGT TGCAGCTGTTTTGTTGACATTCTGAATGCTTCTAAGTAAATACAATTTTTTTTATTAGTATTGT TGTCCTTTTCATAGGTCTGAAATTTTTCTTCTTGAGGGGAAGCTAGTCTTTTGCTTTTGCCCAT TTTGAATCACATGAATTATTACAGTGTTTATCCTTTCATATAGTTAGCTAATAAAAAGCTTTTG TCTACACACCCTGCATATCATAATGGGGGTAAAGTTAAGTTGAGATAGTTTTCATCCATAACTG AACATCCAAAATCTTGATCAGTTAAGAAATTTCACATAGCCCACTTACATTTACAAACTGAAGA GTAATCAATCTACTCAAAGCATGGGATTATTAGAATCAAACATTTTGAAAGTCTGTCCTTGAAG GACTAATAGAAAAGTATGTTCTAACCTTTACATGAGGACTCTATTCTTTAACTCCCATTACCAT GTAATGGCAGTTATATTTTGCAGTTCCCACATTAAAGAAGACCTGAGAATGTATCCCCAAAAGC GTGAGCTTAAAATACAAGACTGCCATATTAAATTTTTTGTTGACATTAGTCTCAGTGAAGACTA TGAAAATGCTGGCTATAGATGTCTTTTCCCATTTATCTAAATATGGACTGCTCAGGAAACGAGA CTTTCCATTACAAGTATTTTTAATTAATTGGGCCAGCTTTTCAAACAAAGATGCCACATTCAAA ATAGGGTATATTTTCCTATATTACGGTTTGCCCCTTTATAAATCCAAGTAGATAGGAAGAAAGA AGACAAACTTTGCATCTCAGTATGAATTATTCAATTTATTTGAATGATTTTTCTTTACAAAACA AACTCATTCATTAGTCATGTTTATCTGCTTAGGAGTTTAGGGAACAATTTGGCAATTTTGTGGT TTTCGAGATTATCGTTTTCTTAAAGTGCCAGTATTTTAAAATAGCGTTCTTGTAATTTTACACG CTTTTGTGATGGAGTGCTGTTTTGTTATATAATTTAGACTTGGATTCTTTCCATTTGCATTTGT TTATGTAATTTCAGGAGGAATACTGAACATCTGAGTCCTGGATGATACTAATAAACTAATAATT GCAGAGGTTTTAAATACTAGTTAAATGGCTTTCACTTAAGAACTTAAGATTTTGTTACATATTT TTAAATCTTGTTTCTAATAATACCTCTTAGCAGTACCTTTTAAATAAGTATAAGGGATGGCAAA GTTTTTCCCTTTAAAAATACTCACTTTATGCTTATAAATAGGTTAATGGGCTGATAAAAGGTTT TGTCAAACATTGCAAGTATTCGGTGCTATATATAAAGGAGGAAAAACTAGTTTTACTTTCAGAA TGATTTAAACAAGATTTTTAAAAACAAGATACATGCAAGCGAACAGCAGGGTTAGTGATAGGCT GCAATTGTGTCGAACATCAGATTTTTTGTTAAGAGGAGCAAATGACTCAATCTGATTTAGATGG AAGTTTCTACTGTATAGAAATCACCATTAATCACCAACATTAATAATTCTGATCCATTTAAAAT GAATTCTGGCTCAAGGAGAATTTGTAACTTTAGTAGGTACGTCATGACAACTACCATTTTTTTA AGATGTTGAGAATGGGAACAGTTTTTTTAGGGTTTATTCTTGACCACAGATCTTAAGAAAATGG ACAAAACCCCTCTTCAATCTGAAGATTAGTATGGTTTGGTGTTCTAACAGTATCCCCTAGAAGT TGGATGTCTAAAACTCAAGTAAATGGAAGTGGGAGGCAATTTAGATAAGTGTAAAGCCTTGTAA CTGAAGATGATTTTTTTTAGAAAGTGTATAGAAACTATTTTAATGCCAAGATAGTTACAGTGCT GTGGGGTTTAAAGACTTTGTTGACATCAAGAAAAGACTAAATCTATAATTAATTGGGCCAACTT TTAAAATGAAGATGCTTTTTAAAACTAATGAACTAAGATGTATAAATCTTAGTTTTTTTGTATT TTAAAGATAGGCATATGGCATATTGATTAACGAGTCAAATTTCCTAACTTTGCTGTGCAAAGGT TGAGAGCTATTGCTGATTAGTTACCACAGTTCTGATGATCGTCCCATCACAGTGTTGTTAATGT TTGCTGTATTTATTAATTTTCTTAAAGTGAAATCTGAAAAATGAAATTTGTGTGTCCTGTGTAC CCGAGGGGTAATGATTAAATGATAAAGATAAGAAAA Download Select all
Length	3428

CDS Information

Location	join(2265..2414,2593..2738,3233..3407,4412..4588)
CDS Sequence	>gi\|118918424:164-811 Homo sapiens high mobility group box 1 (HMGB1), mRNA ATGGGCAAAGGAGATCCTAAGAAGCCGAGAGGCAAAATGTCATCATATGCATTTTTTGTGCAAACTTGTC GGGAGGAGCATAAGAAGAAGCACCCAGATGCTTCAGTCAACTTCTCAGAGTTTTCTAAGAAGTGCTCAGA GAGGTGGAAGACCATGTCTGCTAAAGAGAAAGGAAAATTTGAAGATATGGCAAAAGCGGACAAGGCCCGT TATGAAAGAGAAATGAAAACCTATATCCCTCCCAAAGGGGAGACAAAAAAGAAGTTCAAGGATCCCAATG CACCCAAGAGGCCTCCTTCGGCCTTCTTCCTCTTCTGCTCTGAGTATCGCCCAAAAATCAAAGGAGAACA TCCTGGCCTGTCCATTGGTGATGTTGCGAAGAAACTGGGAGAGATGTGGAATAACACTGCTGCAGATGAC AAGCAGCCTTATGAAAAGAAGGCTGCGAAGCTGAAGGAAAAATACGAAAAGGATATTGCTGCATATCGAG CTAAAGGAAAGCCTGATGCAGCAAAAAAGGGAGTTGTCAAGGCTGAAAAAAGCAAGAAAAAGAAGGAAGA GGAGGAAGATGAGGAAGATGAAGAGGATGAGGAGGAGGAGGAAGATGAAGAAGATGAAGATGAAGAAGAA GATGATGATGATGAATAA Download Select all
CCDS ID	CCDS9335.1

Protein Information

Protein ID	NP_002119.1
Protein Name	High-mobility group box 1
Molecular Wt. (Da)	24763
Protein Sequence	>3146 MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMA KADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKK LGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEE DEEDEEEEEDEEDEDEEEDDDDE Download Select all
Length	215
Uniprot ID	Q08345
Ensembl Protein ID	ENSP00000259875

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
S	Phosphorylation	100
S	Phosphorylation	35
Y	Phosphorylation	155
Y	Phosphorylation	162
K	Acetylation	30
K	Acetylation	12
K	Acetylation	157
K	Acetylation	59
K	Acetylation	82
K	Acetylation	154
K	Acetylation	43
K	Acetylation	146
Y	Phosphorylation	109
S	Phosphorylation	121

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
1523	CUX1	295	NP_853530.2	in vitro	11748221
1786	DNMT1	532	NP_001124295.1	in vitro	11748221
3235	HOXD9	865	NP_055028.3	in vitro;in vivo	8890171
3280	HES1	770	NP_005515.1	in vitro	11748221
3516	RBPJ	920	NP_005340.2	in vitro	11748221
3660	IRF2	962	NP_002190.2	in vitro	11748221
7099	TLR4	4325	NP_612564.1	in vivo	16267105
9094	UNC119	4927	NP_005139.1	yeast 2-hybrid	16169070
11161	C14orf1	5201	NP_009107.1	yeast 2-hybrid	16169070
55791	C1orf103	17975	NP_060842.3	yeast 2-hybrid	16169070

Pathway Information

Pathway Name	Pathway ID
Base excision repair	hsa03410

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd01390	Jun-76	HMGB-UBF_HMG-box
cl00082	Jun-76	HMG-box superfamily
cd01390	95-160	HMGB-UBF_HMG-box
cl00082	95-160	HMG-box superfamily
pfam09011	Jun-78	HMG_box_2
pfam00505	95-163	HMG_box
cd00084	Jun-76	HMG-box
cd00084	95-160	HMG-box
smart00398	Aug-78	HMG
smart00398	94-163	HMG
pfam00505	Jun-78	HMG_box
PTZ00199	Mar-78	PTZ00199
PTZ00199	86-163	PTZ00199
cd01388	96-144	SOX-TCF_HMG-box
cd01389	95-144	MATA_HMG-box
pfam09011	92-162	HMG_box_2
cd01388	Jul-74	SOX-TCF_HMG-box
COG5648	3-157	NHP6B
COG5648	85-168	NHP6B

Ontology Information

HPRD ID	2678
Molecular Class	DNA binding protein
Molecular Function	Transmembrane receptor protein tyrosine kinase activity (GO:0004714)
Biological Process	Cell communication (GO:0007154); Signal transduction (GO:0007165)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

Important Information

Mechanism Down-regulation
Biomarker -
Drug Target -
Biological Process Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism