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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
HNF4A 3172 hepatocyte nuclear factor 4, alpha  20NR2A1, HNF4 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24619225   2014Cell line : HCT116, DLD1, SW480, HT29

Source : ATCC

Sample Type : -

No. of Sample : -

Stage : -

 Transfection,Annexin V-FITC Apoptosis,Measurement of Mitochondrial Membrane Potential,Real-Time PCR,Western Blotting,Chromatin Immunoprecipitation Down-regulation-Positive feedback loop between miR-124 and PKM1/HNF4? plays an important role in colorectal cancer cell apoptosis


Gene Details



NC_000020.10 (42984441..43061485)

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Gene Type protein coding
Gene Family Nuclear hormone receptors
Description The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Apr 2012]  
Chromosome 20
Location 20q13.12
Start 42984441  
End 43061485  
Strand +  
Gene Sequence

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Length 77045  
OMIM ID 600281   
HGNC ID HGNC:5024   
Unigene ID Hs.116462   
Ensembl ID ENSG00000101076   
PharmGKB ID PA29349   

mRNA Information


mRNA ID NM_001287183.1
Exon join(1..53,34658..34879,50258..50432,51581..51675, 57894..58000,58707..58862,62625..62712,63921..64076, 68218..68454,72535..72687,73723..77045)  
mRNA Sequence

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Length 4780  



CDS Information


   
Location236..1585
CDS Sequence

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CCDS ID CCDS13330.1



Protein Information


      
Protein IDNP_001274112.1
Protein Namehepatocyte nuclear factor 4, alpha
Molecular Wt. (Da)49860
Protein Sequence

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Length 449  
Uniprot IDP18827
Ensembl Protein ID ENSP00000254351  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation343
SPhosphorylation313
SPhosphorylation313
SPhosphorylation313
SPhosphorylation167
SPhosphorylation167
SPhosphorylation145
SPhosphorylation145
SPhosphorylation167
SPhosphorylation145

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1387CREBBP2534NP_004371.2in vitro;yeast 2-hybrid943   476   510   085   149   
2308FOXO1645NP_002006.2in vitro12519792   
4878NPPA164NP_006163.1yeast 2-hybrid15604093   
6667SP11796NP_612482.2in vitro19115260   
6927HNF1A800NP_000536.5in vitro9792724   
7025NR2F1584NP_005645.1in vitro10652338   
7157TP531859NP_000537.3in vitro11818510   
7329UBE2I9045NP_003336.1yeast 2-hybrid15604093   
8204NRIP13927NP_003480.2yeast 2-hybrid15604093   
8648NCOA14070NP_003734.3yeast 2-hybrid9812974   
9282MED142172NP_004220.2in vitro12101254   
10891PPARGC1A5155NP_037393.1in vitro;in vivo1   582   695   415   744   310   
10957PNRC18412NP_006804.1yeast 2-hybrid15604093   
10987COPS56888NP_006828.2yeast 2-hybrid15604093   
23054NCOA65599NP_054790.2yeast 2-hybrid15604093   
23411SIRT18381NP_036370.2in vivo15744310   
55629PNRC217871NP_060231.1yeast 2-hybrid15604093   


Pathway Information


            
Pathway Name Pathway ID
AMPK signaling pathway hsa04152
Maturity onset diabetes of the young hsa04950


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd06931151-373  NR_LBD_HNF4_like
cl11397151-373  NR_LBD superfamily
cd0696060-135  NR_DBD_HNF4A
cl0259660-135  NR_DBD_like superfamily
cd06930184-347  NR_LBD_F2
cd06943151-359  NR_LBD_RXR_like
cd0691660-131  NR_DBD_like
pfam0010559-127  zf-C4
pfam00104169-361  Hormone_recep
cd06948181-379  NR_LBD_COUP-TF
cd0696159-141  NR_DBD_TR
cd0696759-141  NR_DBD_TR2_like
cd06157186-347  NR_LBD
cd0695659-134  NR_DBD_RXR
smart0039959-128  ZnF_C4
cd0716460-135  NR_DBD_PNR_like_1
smart00430191-347  HOLI
cd0695860-131  NR_DBD_COUP_TF
cd0716360-134  NR_DBD_TLX
cd0696959-131  NR_DBD_NGFI-B
cd0696456-136  NR_DBD_RAR
cd0715460-131  NR_DBD_PNR_like
cd0697059-139  NR_DBD_PNR
cd0695760-134  NR_DBD_PNR_like_2
cd0716856-134  NR_DBD_DHR4_like
cd0716760-144  NR_DBD_Lrh-1_like
cd0715660-130  NR_DBD_VDR_like
cd0696860-147  NR_DBD_ROR
cd0716960-134  NR_DBD_GCNF_like
cd0695959-130  NR_DBD_EcR_like
cd06950187-362  NR_LBD_Tlx_PNR_like
cd0695555-142  NR_DBD_VDR
cd0716560-140  NR_DBD_DmE78_like
cd0716159-133  NR_DBD_EcR
cd0716050-133  NR_DBD_LXR
cd0696660-145  NR_DBD_CAR
cd0717960-132  2DBD_NR_DBD2
cd0715560-134  NR_DBD_ER_like
cd0716655-134  NR_DBD_REV_ERB
cd0717158-136  NR_DBD_ER
cd0716259-141  NR_DBD_PXR
cd0715860-131  NR_DBD_Ppar_like
cd0696559-134  NR_DBD_Ppar
cd0696259-133  NR_DBD_FXR
cd06952187-370  NR_LBD_TR2_like
cd0717059-136  NR_DBD_ERR
cd07068152-374  NR_LBD_ER_like
cd06946152-323  NR_LBD_ERR
cd0717360-125  NR_DBD_AR
cd0717257-129  NR_DBD_GR_PR
cd0696360-129  NR_DBD_GR_like
cd06951174-372  NR_LBD_Dax1_like
cd06929184-348  NR_LBD_F1
cd0715760-127  2DBD_NR_DBD1
cd07069152-374  NR_LBD_Lrh-1
cd06944152-374  NR_LBD_Ftz-F1_like
cd07349188-374  NR_LBD_SHP
cd06938198-372  NR_LBD_EcR
cd06935173-360  NR_LBD_TR
cd06953188-363  NR_LBD_DHR4_like
cd07350187-372  NR_LBD_Dax1
cd06934184-373  NR_LBD_PXR_like
cd06954198-373  NR_LBD_LXR
cd06945146-362  NR_LBD_Nurr1_like
cd06949147-325  NR_LBD_ER
cd07070177-374  NR_LBD_SF-1
cd06937198-374  NR_LBD_RAR
cd06941199-315  NR_LBD_DmE78_like
cd06932198-372  NR_LBD_PPAR
cd06933176-334  NR_LBD_VDR
cd07071152-374  NR_LBD_Nurr1
cd06936194-315  NR_LBD_Fxr
cd06939199-319  NR_LBD_ROR_like
cd06940198-347  NR_LBD_REV_ERB
cd06942199-298  NR_LBD_Sex_1_like
cd07348195-360  NR_LBD_NGFI-B
cd07074181-327  NR_LBD_PR
cd07072197-379  NR_LBD_DHR38_like
cd07073183-295  NR_LBD_AR
cd06947194-221  NR_LBD_GR_Like
cd07076193-295  NR_LBD_GR
cd07075193-221  NR_LBD_MR


Ontology Information


   
HPRD ID803
Molecular ClassNuclear receptor
Molecular FunctionCell adhesion molecule activity (GO:0005194)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO