Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| HNRPH2 | 3188 | Heterogeneous nuclear ribonucleoprotein H2 (H') | X | FTP3; HNRPH'; HNRPH2; hnRNPH' |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20089989 | 2010 | Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tumor and control tissue No. of Sample : - Stage : - | Biochemical isolation to nano-LC-MS/MS analysis | Down-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | RNA binding motif (RRM) containing |
| Description | This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that binds to RNAs. It is very similar to the family member HNRPH1. This gene is thought to be involved in Fabray disease and X-linked agammaglobulinemia phenotype. Alternative splicing results in multiple transcript variants encoding the same protein. Read-through transcription between this locus and the ribosomal protein L36a gene has been observed. [provided by RefSeq, Jan 2011] |
| Chromosome | X |
| Location | Xq22 |
| Start | 101408133 |
| End | 101414140 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 6008 |
| OMIM ID | 300610 |
| HGNC ID | HGNC:5042 |
| Unigene ID | Hs.432485 |
| Ensembl ID | ENSG00000126945 |
| PharmGKB ID | PA29366 |
mRNA Information
| mRNA ID | NM_001199973.1 |
|---|---|
| Exon | <3804..6008 | mRNA Sequence | Download Select all |
| Length | 2659 |
Protein Information
| Protein ID | NP_001027565.1 |
|---|---|
| Protein Name | Heterogeneous nuclear ribonucleoprotein H2 (H') |
| Molecular Wt. (Da) | 49133 |
| Protein Sequence | Download Select all |
| Length | 449 |
| Uniprot ID | P27824 |
| Ensembl Protein ID | ENSP00000247461 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 104 |
| Y | Phosphorylation | 240;- |
| Y | Phosphorylation | 249;- |
| Y | Phosphorylation | 236;- |
| Y | Phosphorylation | 246;- |
| Y | Phosphorylation | 240;- |
| Y | Phosphorylation | 249;- |
| Y | Phosphorylation | 236;- |
| Y | Phosphorylation | 246;- |
| S | Phosphorylation | 310 |
| S | Phosphorylation | 310 |
| S | Phosphorylation | 104 |
| T | Phosphorylation | 107 |
| T | Phosphorylation | 107 |
| T | Phosphorylation | 100 |
| T | Phosphorylation | 100 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
| PDB ID | 1WEZ |
|---|---|
| Resolution | - |
| Method | solution NMR |
| Chains | A |
| Molecule | Heterogeneous nuclear ribonucleoprotein H' |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd12729 | Oct-88 | RRM1_hnRNPH_hnRNPH2_hnRNPF |
| cl17169 | Oct-88 | RRM_SF superfamily |
| cd12734 | 289-364 | RRM3_hnRNPH_hnRNPH2_hnRNPF |
| cl17169 | 289-364 | RRM_SF superfamily |
| cd12732 | 93-188 | RRM2_hnRNPH3 |
| cl17169 | 93-188 | RRM_SF superfamily |
| cd12731 | 110-192 | RRM2_hnRNPH_hnRNPH2_hnRNPF |
| cd12504 | 111-187 | RRM2_hnRNPH_like |
| cd12506 | 289-363 | RRM3_hnRNPH_CRSF1_like |
| cd12735 | 289-363 | RRM3_hnRNPH3 |
| cd12733 | 289-363 | RRM3_GRSF1 |
| cd12503 | Dec-88 | RRM1_hnRNPH_GRSF1_like |
| cd12505 | 110-184 | RRM2_GRSF1 |
| cd12730 | Nov-87 | RRM1_GRSF1 |
| cd12254 | 112-184 | RRM_hnRNPH_ESRPs_RBM12_like |
| cd12508 | Oct-88 | RRM2_ESRPs_Fusilli |
| cd12508 | 110-186 | RRM2_ESRPs_Fusilli |
| cd12254 | Dec-86 | RRM_hnRNPH_ESRPs_RBM12_like |
| cd12254 | 290-360 | RRM_hnRNPH_ESRPs_RBM12_like |
| cd12507 | 113-186 | RRM1_ESRPs_Fusilli |
| cd12504 | Nov-88 | RRM2_hnRNPH_like |
| cd12508 | 290-360 | RRM2_ESRPs_Fusilli |
| cd12505 | Dec-86 | RRM2_GRSF1 |
| cd12738 | 113-187 | RRM1_Fusilli |
| cd12507 | Dec-88 | RRM1_ESRPs_Fusilli |
| cd12502 | Nov-86 | RRM2_RMB19 |
| cd12506 | 112-187 | RRM3_hnRNPH_CRSF1_like |
| cd12504 | 289-363 | RRM2_hnRNPH_like |
| cd12731 | Sep-93 | RRM2_hnRNPH_hnRNPH2_hnRNPF |
| cd12732 | May-89 | RRM2_hnRNPH3 |
| cd12741 | 113-186 | RRM2_Fusilli |
| cd12740 | Mar-97 | RRM2_ESRP2 |
| cd12506 | Dec-86 | RRM3_hnRNPH_CRSF1_like |
| cd12509 | 113-187 | RRM3_ESRPs_Fusilli |
| cd12740 | 109-192 | RRM2_ESRP2 |
| pfam08080 | 257-290 | zf-RNPHF |
| cl06907 | 257-290 | zf-RNPHF superfamily |
| cd12741 | Dec-88 | RRM2_Fusilli |
| cd12739 | Dec-97 | RRM2_ESRP1 |
| cd12739 | 109-192 | RRM2_ESRP1 |
| cd12502 | 113-184 | RRM2_RMB19 |
| cd12509 | 13-87 | RRM3_ESRPs_Fusilli |
| cd12736 | 109-187 | RRM1_ESRP1 |
| cd12502 | 289-360 | RRM2_RMB19 |
| cd12505 | 291-360 | RRM2_GRSF1 |
| cd12737 | 113-190 | RRM1_ESRP2 |
| cd12735 | 112-187 | RRM3_hnRNPH3 |
| cd12733 | 112-187 | RRM3_GRSF1 |
| cd12503 | 291-360 | RRM1_hnRNPH_GRSF1_like |
| cd12746 | 112-190 | RRM2_RBM12B |
| cd12509 | 290-360 | RRM3_ESRPs_Fusilli |
| cd12731 | 291-365 | RRM2_hnRNPH_hnRNPH2_hnRNPF |
| cd12738 | Dec-88 | RRM1_Fusilli |
| cd12742 | 13-87 | RRM3_ESRP1_ESRP2 |
| cd12742 | 113-187 | RRM3_ESRP1_ESRP2 |
| cd12514 | 113-183 | RRM4_RBM12_like |
| cd12729 | 288-360 | RRM1_hnRNPH_hnRNPH2_hnRNPF |
| cd12511 | 112-186 | RRM2_RBM12_like |
| cd12736 | Dec-88 | RRM1_ESRP1 |
| cd12511 | 291-361 | RRM2_RBM12_like |
| cd12746 | 13-95 | RRM2_RBM12B |
| cd12512 | 113-202 | RRM3_RBM12 |
| cd12512 | 288-359 | RRM3_RBM12 |
| cd12737 | Dec-92 | RRM1_ESRP2 |
| cd12733 | 13-86 | RRM3_GRSF1 |
| cd12741 | 279-360 | RRM2_Fusilli |
| cd00590 | 113-183 | RRM_SF |
| cd12740 | 291-365 | RRM2_ESRP2 |
| pfam00076 | 113-182 | RRM_1 |
| cd00590 | 13-85 | RRM_SF |
| cd12734 | 113-187 | RRM3_hnRNPH_hnRNPH2_hnRNPF |
| cd12746 | 293-359 | RRM2_RBM12B |
| cd12507 | 290-360 | RRM1_ESRPs_Fusilli |
| cd12391 | 13-81 | RRM1_SART3 |
| cd12514 | Dec-85 | RRM4_RBM12_like |
| cd12747 | 110-183 | RRM2_RBM12 |
| cd12742 | 290-360 | RRM3_ESRP1_ESRP2 |
| cd12512 | Aug-85 | RRM3_RBM12 |
| cd12738 | 291-360 | RRM1_Fusilli |
| cd00590 | 291-347 | RRM_SF |
| cd12749 | 115-179 | RRM4_RBM12 |
| cd12735 | 13-86 | RRM3_hnRNPH3 |
| cd12511 | 13-88 | RRM2_RBM12_like |
| cd12510 | Dec-88 | RRM1_RBM12_like |
| cd12450 | 15-85 | RRM1_NUCLs |
| cd12510 | 112-187 | RRM1_RBM12_like |
| cd12748 | 115-180 | RRM4_RBM12B |
| cd12744 | 113-192 | RRM1_RBM12B |
| cd12751 | 113-183 | RRM5_RBM12 |
| cd12750 | 113-183 | RRM5_RBM12B |
| cd12515 | 111-184 | RRM5_RBM12_like |
| cd12747 | 291-359 | RRM2_RBM12 |
| cd12739 | 291-365 | RRM2_ESRP1 |
| cd12510 | 291-363 | RRM1_RBM12_like |
| cd12743 | 13-87 | RRM3_Fusilli |
| cd12747 | Nov-85 | RRM2_RBM12 |
| cd12743 | 113-187 | RRM3_Fusilli |
| cd12734 | 13-86 | RRM3_hnRNPH_hnRNPH2_hnRNPF |
| pfam00076 | 293-347 | RRM_1 |
| cd12730 | 291-360 | RRM1_GRSF1 |
| pfam00076 | 15-73 | RRM_1 |
| cd12515 | 290-360 | RRM5_RBM12_like |
| cd12514 | 290-359 | RRM4_RBM12_like |
| cd12392 | 15-90 | RRM2_SART3 |
| cd12413 | 112-171 | RRM1_RBM28_like |
| cd12391 | 118-179 | RRM1_SART3 |
| cd12751 | Dec-71 | RRM5_RBM12 |
| cd12414 | 115-170 | RRM2_RBM28_like |
| cd12737 | 291-360 | RRM1_ESRP2 |
| cd12736 | 291-360 | RRM1_ESRP1 |
| cd12296 | 13-85 | RRM1_Prp24 |
| cd12513 | 112-188 | RRM3_RBM12B |
| cd12515 | Dec-86 | RRM5_RBM12_like |
| cd12296 | 291-349 | RRM1_Prp24 |
| cd12450 | 116-183 | RRM1_NUCLs |
| cd12402 | 296-355 | RRM_eIF4B |
| cd12271 | 13-85 | RRM1_PHIP1 |
| cd12513 | Nov-86 | RRM3_RBM12B |
| cd12450 | 291-359 | RRM1_NUCLs |
| cd12513 | 289-360 | RRM3_RBM12B |
| cd12271 | 291-356 | RRM1_PHIP1 |
| cd12298 | 113-183 | RRM3_Prp24 |
| cd12744 | 291-365 | RRM1_RBM12B |
| cd12745 | 113-200 | RRM1_RBM12 |
| cd12271 | 117-183 | RRM1_PHIP1 |
| cd12399 | 15-85 | RRM_HP0827_like |
| cd12448 | 118-170 | RRM2_gar2 |
| cd12320 | 115-171 | RRM6_RBM19_RRM5_MRD1 |
| cd12316 | 294-360 | RRM3_RBM19_RRM2_MRD1 |
| cd12415 | 115-170 | RRM3_RBM28_like |
| cd12281 | 13-72 | RRM1_TatSF1_like |
| cd12306 | 120-169 | RRM_II_PABPs |
| cd12400 | 118-183 | RRM_Nop6 |
| cd12566 | 293-355 | RRM2_MRD1 |
| cd12404 | 15-71 | RRM2_NCL |
| cd12313 | 294-345 | RRM1_RRM2_RBM5_like |
| cd12230 | 295-348 | RRM1_U2AF65 |
| cd12272 | Dec-85 | RRM2_PHIP1 |
| cd12750 | 291-345 | RRM5_RBM12B |
| cd12316 | 115-170 | RRM3_RBM19_RRM2_MRD1 |
| cd12400 | Nov-73 | RRM_Nop6 |
| cd12674 | 293-347 | RRM1_Nop4p |
| cd12278 | 134-171 | RRM_eIF3B |
| cd12589 | 123-171 | RRM2_PSP1 |
| cd12395 | 18-86 | RRM2_RBM34 |
| cd12591 | 115-174 | RRM2_p54nrb |
| cd12743 | 290-360 | RRM3_Fusilli |
| cd12418 | 291-347 | RRM_Aly_REF_like |
| cd12748 | 15-82 | RRM4_RBM12B |
| cd12448 | 296-345 | RRM2_gar2 |
| cd12749 | 290-355 | RRM4_RBM12 |
| cd12399 | 296-347 | RRM_HP0827_like |
| cd12283 | 296-346 | RRM1_RBM39_like |
| cd12320 | 291-347 | RRM6_RBM19_RRM5_MRD1 |
| cd12404 | 115-169 | RRM2_NCL |
| cd12745 | 291-363 | RRM1_RBM12 |
| cd12674 | 115-173 | RRM1_Nop4p |
| cd12404 | 293-359 | RRM2_NCL |
| cd12412 | 115-170 | RRM_DAZL_BOULE |
| cd12448 | 18-77 | RRM2_gar2 |
| cd12291 | 291-349 | RRM1_La |
| cd12402 | 118-183 | RRM_eIF4B |
| cd12387 | 291-344 | RRM3_hnRNPM_like |
| cd12333 | 145-174 | RRM2_p54nrb_like |
| cd12239 | 148-170 | RRM2_RBM40_like |
| cd12750 | 13-85 | RRM5_RBM12B |
| cd12567 | 293-346 | RRM3_RBM19 |
| cd12384 | 294-355 | RRM_RBM24_RBM38_like |
| cd12408 | 149-180 | RRM_eIF3G_like |
| cd12744 | Dec-93 | RRM1_RBM12B |
| cd12745 | Dec-93 | RRM1_RBM12 |
| cd12413 | 294-347 | RRM1_RBM28_like |
| pfam14259 | 13-84 | RRM_6 |
| pfam14259 | 113-182 | RRM_6 |
| pfam14259 | 291-358 | RRM_6 |
| smart00360 | 113-183 | RRM |
| smart00360 | 290-359 | RRM |
| smart00360 | Dec-85 | RRM |
| COG0724 | 289-345 | RRM |
| COG0724 | 58-172 | RRM |
| TIGR01628 | 50-171 | PABP-1234 |
| COG0724 | 6-189 | RRM |
| TIGR01622 | 3-171 | SF-CC1 |
Ontology Information
| HPRD ID | 252 |
|---|---|
| Molecular Class | Unknown |
| Molecular Function | Chaperone activity (GO:0003754) |
| Biological Process | Protein folding (GO:0006457) |
Drug Information
No matching records could be found.