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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
HNRPH3 3189 Heterogeneous nuclear ribonucleoprotein H3 (2H9)  102H9; HNRPH3 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
20089989   2010Cell line : -

Source : VU University Medical Center, Amsterdam, The Netherlands.

Sample Type : CRC tumor and control tissue

No. of Sample : -

Stage : -

Biochemical isolation to nano-LC-MS/MS analysisDown-regulation--


Gene Details



Chromosome: 10; NC_000010.10 (70091768..70102953)

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Gene Type protein coding
Gene Family RNA binding motif (RRM) containing
Description This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is localized in nuclear bodies of the nucleus. This protein is involved in the splicing process and it also participates in early heat shock-induced splicing arrest by transiently leaving the hnRNP complexes. Several alternatively spliced transcript variants have been noted for this gene, however, not all are fully characterized. [provided by RefSeq, Jul 2008]  
Chromosome 10
Location 10q22
Start 68332011  
End 68343196  
Strand +  
Gene Sequence

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Length 11186  
OMIM ID 602324   
HGNC ID HGNC:5043   
Unigene ID Hs.643472   
Ensembl ID ENSG00000096746   
PharmGKB ID -   

mRNA Information


mRNA ID XM_005270028.2
Exon complement(774..918)  
mRNA Sequence

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Length 2427  



CDS Information


   
Location join(5212..5323,5848..5986,6493..6677,7130..7216, 7430..7545,9164..9299,9575..9670,9749..9841,9968..10044)
CDS Sequence

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CCDS ID CCDS7278.1



Protein Information


      
Protein IDNP_036339.1
Protein NameHeterogeneous nuclear ribonucleoprotein H3 (2H9)
Molecular Wt. (Da)36796
Protein Sequence

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Length 346  
Uniprot IDP29466
Ensembl Protein ID ENSP00000344132  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation153;-
YPhosphorylation159;-
YPhosphorylation296;-
YPhosphorylation281;-
YPhosphorylation296;-
YPhosphorylation281;-
SPhosphorylation216;-
SPhosphorylation201;-
YPhosphorylation143
YPhosphorylation147
SPhosphorylation269
SPhosphorylation254
SPhosphorylation298
SPhosphorylation283
TPhosphorylation270
TPhosphorylation255

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                        
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1400CRMP13913NP_001014809.1yeast 2-hybrid16169070   
1937EEF1G11745NP_001395.1yeast 2-hybrid16169070   
6191RPS4X2427NP_000998.1yeast 2-hybrid16169070   
6357CCL133230NP_005399.1yeast 2-hybrid16169070   
7276TTR1447NP_000362.1yeast 2-hybrid16169070   
10813UTP14A6712NP_006640.2yeast 2-hybrid16169070   
11040PIM22244NP_006866.2yeast 2-hybrid16169070   
11161C14orf15201NP_009107.1yeast 2-hybrid16169070   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd12732Jan-93  RRM2_hnRNPH3
cl17169Jan-93  RRM_SF superfamily
cd12735195-269  RRM3_hnRNPH3
cl17169195-269  RRM_SF superfamily
cd1250416-92  RRM2_hnRNPH_like
cd1273115-97  RRM2_hnRNPH_hnRNPH2_hnRNPF
cd12506195-269  RRM3_hnRNPH_CRSF1_like
cd12734195-270  RRM3_hnRNPH_hnRNPH2_hnRNPF
cd12733195-269  RRM3_GRSF1
cd1250515-89  RRM2_GRSF1
cd1250815-91  RRM2_ESRPs_Fusilli
cd1225417-89  RRM_hnRNPH_ESRPs_RBM12_like
cd12254196-266  RRM_hnRNPH_ESRPs_RBM12_like
cd1250318-91  RRM1_hnRNPH_GRSF1_like
cd1250718-91  RRM1_ESRPs_Fusilli
cd12504195-269  RRM2_hnRNPH_like
cd12508197-266  RRM2_ESRPs_Fusilli
cd1274118-91  RRM2_Fusilli
cd1273818-95  RRM1_Fusilli
cd1250617-92  RRM3_hnRNPH_CRSF1_like
cd1272918-91  RRM1_hnRNPH_hnRNPH2_hnRNPF
cd1273918-97  RRM2_ESRP1
cd1274018-97  RRM2_ESRP2
cd12502195-266  RRM2_RMB19
cd1250918-92  RRM3_ESRPs_Fusilli
cd1250217-89  RRM2_RMB19
cd12505197-266  RRM2_GRSF1
cd12503197-266  RRM1_hnRNPH_GRSF1_like
cd1273615-92  RRM1_ESRP1
cd1273718-95  RRM1_ESRP2
cd1273317-92  RRM3_GRSF1
cd12731196-269  RRM2_hnRNPH_hnRNPH2_hnRNPF
cd1274620-95  RRM2_RBM12B
cd1274218-92  RRM3_ESRP1_ESRP2
cd12509197-266  RRM3_ESRPs_Fusilli
cd1273518-92  RRM3_hnRNPH3
cd1251218-88  RRM3_RBM12
cd12729194-266  RRM1_hnRNPH_hnRNPH2_hnRNPF
cd1251418-88  RRM4_RBM12_like
cd12507197-266  RRM1_ESRPs_Fusilli
cd1273018-89  RRM1_GRSF1
cd12511196-267  RRM2_RBM12_like
cd1251118-91  RRM2_RBM12_like
cd12741197-266  RRM2_Fusilli
cd12740197-266  RRM2_ESRP2
cd0059018-88  RRM_SF
cd12746196-265  RRM2_RBM12B
pfam0007618-87  RRM_1
cd12512194-265  RRM3_RBM12
cd1273418-92  RRM3_hnRNPH_hnRNPH2_hnRNPF
cd12738197-266  RRM1_Fusilli
cd12737197-266  RRM1_ESRP2
cd00590197-256  RRM_SF
cd1275118-88  RRM5_RBM12
cd12736197-266  RRM1_ESRP1
cd1274715-88  RRM2_RBM12
cd12747196-265  RRM2_RBM12
cd1275018-88  RRM5_RBM12B
cd12730197-266  RRM1_GRSF1
cd12739197-266  RRM2_ESRP1
cd1274418-97  RRM1_RBM12B
cd1274318-92  RRM3_Fusilli
cd12510196-269  RRM1_RBM12_like
cd1274820-80  RRM4_RBM12B
cd12742197-266  RRM3_ESRP1_ESRP2
cd1251516-89  RRM5_RBM12_like
cd12450197-263  RRM1_NUCLs
cd1245017-88  RRM1_NUCLs
cd1251318-93  RRM3_RBM12B
cd1239117-84  RRM1_SART3
cd1274920-84  RRM4_RBM12
cd12515197-266  RRM5_RBM12_like
cd12296197-264  RRM1_Prp24
cd12316200-266  RRM3_RBM19_RRM2_MRD1
cd1251018-92  RRM1_RBM12_like
pfam00076196-253  RRM_1
cd12674199-260  RRM1_Nop4p
cd1241517-74  RRM3_RBM28_like
cd12320197-256  RRM6_RBM19_RRM5_MRD1
cd1274518-105  RRM1_RBM12
cd12514197-265  RRM4_RBM12_like
cd1241317-76  RRM1_RBM28_like
cd12680197-259  RRM_THOC4
cd1230625-74  RRM_II_PABPs
cd12402202-263  RRM_eIF4B
cd12744197-269  RRM1_RBM12B
cd12750197-253  RRM5_RBM12B
cd12413196-256  RRM1_RBM28_like
cd12418197-253  RRM_Aly_REF_like
cd12399202-263  RRM_HP0827_like
cd12225197-254  RRM1_2_CID8_like
cd1232020-74  RRM6_RBM19_RRM5_MRD1
cd12566199-263  RRM2_MRD1
cd1227122-88  RRM1_PHIP1
cd12743197-266  RRM3_Fusilli
cd1241420-74  RRM2_RBM28_like
cd12513195-266  RRM3_RBM12B
cd1244823-74  RRM2_gar2
cd12230201-254  RRM1_U2AF65
cd12313200-263  RRM1_RRM2_RBM5_like
cd1240023-88  RRM_Nop6
cd1229617-88  RRM1_Prp24
cd1240217-88  RRM_eIF4B
cd1238421-74  RRM_RBM24_RBM38_like
cd1223022-75  RRM1_U2AF65
cd1229818-88  RRM3_Prp24
cd12567199-265  RRM3_RBM19
cd12392195-271  RRM2_SART3
cd12415196-247  RRM3_RBM28_like
cd12269197-250  RRM_Vip1_like
cd1267417-78  RRM1_Nop4p
cd12271197-263  RRM1_PHIP1
cd1241817-73  RRM_Aly_REF_like
cd12421197-252  RRM1_PTBP1_hnRNPL_like
cd12283202-251  RRM1_RBM39_like
cd12391202-261  RRM1_SART3
pfam14259197-264  RRM_6
pfam1425918-87  RRM_6
smart0036017-88  RRM
smart00360197-253  RRM
COG0724Jun-77  RRM
COG0724197-256  RRM


Ontology Information


   
HPRD ID977
Molecular ClassUnknown
Molecular FunctionCysteine-type peptidase activity (GO:0008234)
Biological ProcessApoptosis (GO:0006915)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO