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General Information
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 10833444 | 2000 | Cell line : Caco 2, HT 29, LS174T Source : - Sample Type : - No. of Sample : - Stage : - | RT-PCR | Down-regulation | - | The reciprocal deregulation of HOX and Cdx-1 genes in CRC and in CRC-derived cell lines suggests a possible role in human CRC development. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Homeoboxes / ANTP class : HOXL subclass |
| Description | This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development, including that of lung and skin, and has been localized to both the nucleus and cytoplasm. Altered expression of this gene or a change in the subcellular localization of its protein is associated with some cases of acute myeloid leukemia and colorectal cancer. [provided by RefSeq, Jul 2008] |
| Chromosome | 17 |
| Location | 17q21.32 |
| Start | 46673099 |
| End | 46682343 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 9245 |
| OMIM ID | 142961 |
| HGNC ID | HGNC:5117 |
| Unigene ID | Hs.98428 |
| Ensembl ID | ENSG00000108511 |
| PharmGKB ID | PA29393 |
mRNA Information
| mRNA ID | XM_005257284.2 |
|---|---|
| Exon | join(1..513,6733..7257,8321..10898) | mRNA Sequence | Download Select all |
| Length | 3616 |
Protein Information
| Protein ID | XP_005257341.1 |
|---|---|
| Protein Name | homeobox B6 |
| Molecular Wt. (Da) | 25301 |
| Protein Sequence | Download Select all |
| Length | 224 |
| Uniprot ID | O00560 |
| Ensembl Protein ID | ENSP00000260130 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 214 |
| S | Phosphorylation | 211;- |
| S | Phosphorylation | 211;- |
| S | Phosphorylation | 214;- |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1387 | CREBBP | 2534 | NP_004371.2 | in vitro;in vivo | 11585930 |
| 2033 | EP300 | 4078 | NP_001420.2 | in vitro;in vivo | 11585930 |
| 3866 | KRT15 | 1009 | NP_002266.2 | yeast 2-hybrid | 16189514 |
| 5359 | PLSCR1 | 8855 | NP_066928.1 | yeast 2-hybrid | 16189514 |
| 6303 | SAT1 | 2431 | NP_002961.1 | yeast 2-hybrid | 16189514 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00086 | 147-205 | homeodomain |
| cl00084 | 147-205 | homeodomain superfamily |
| pfam00046 | 147-203 | Homeobox |
| smart00389 | 146-202 | HOX |
| COG5576 | 138-207 | COG5576 |
Ontology Information
| HPRD ID | 2904 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Chemokine activity (GO:0008009) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.