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General Information
- Evidence
- Gene
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21474578 | 2011 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 224 Stage : - | Western blotting and real-time RT-PCR ,immunohistochemistry,MTT assay, colony formation assay, cell cycle analysis, soft agar assay | Up-regulation | - | HOXB7 protein, as a valuable marker of CRC prognosis, plays an important role in the development and progression of human CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Homeoboxes / ANTP class : HOXL subclass |
| Description | This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma. [provided by RefSeq, Jul 2008] |
| Chromosome | 17 |
| Location | 17q21.32 |
| Start | 46684594 |
| End | 46688383 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 3790 |
| OMIM ID | 142962 |
| HGNC ID | HGNC:5118 |
| Unigene ID | Hs.436181 |
| Ensembl ID | - |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_004502.3 |
|---|---|
| Exon | join(1..503,2927..3790) | mRNA Sequence | Download Select all |
| Length | 1377 |
Protein Information
| Protein ID | NP_004493.3 |
|---|---|
| Protein Name | homeobox B7 |
| Molecular Wt. (Da) | 23884 |
| Protein Sequence | Download Select all |
| Length | 217 |
| Uniprot ID | P48061 |
| Ensembl Protein ID | ENSP00000339913 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 133 |
| T | Phosphorylation | 204 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2033 | EP300 | 4078 | NP_001420.2 | in vitro;in vivo | 11585930 |
| 3216 | HOXB6 | 849 | NP_061825.2 | in vivo | 7729685 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00086 | 138-196 | homeodomain |
| cl00084 | 138-196 | homeodomain superfamily |
| pfam00046 | 138-194 | Homeobox |
| smart00389 | 137-193 | HOX |
| COG5576 | 138-200 | COG5576 |
Ontology Information
| HPRD ID | 1707 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Catalytic activity (GO:0003824) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.