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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20089989 | 2010 | Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tumor and control tissue No. of Sample : - Stage : - | Biochemical isolation to nano-LC-MS/MS analysis | Up-regulation | 6,2 | - |
| 21150566 | 2011 | Cell line : - Source : - Sample Type : CRC tumor, control and Stool sample No. of Sample : 190 participants (150 patients and 40 healthy individuals) and Stool sample Stage : - | - | Up-regulation | - | Fecal Hb-Hp complex, MPO, and sIgA can effectively be used as screening tools for the early diagnosis of colorectal cancer. |
| 21953030 | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | ELISA | Up-regulation | - | Clusterin (CLI) and haptoglobin (HP) are biomarkers condidate have the potential to discriminate accurately between control and cancer groups both individually and in combination with other proteins. |
| 22006099 | 2012 | Cell line : - Source : - Sample Type : CRC tumor and control tissue No. of Sample : 77 Stage : TNM Stag I-IV | - | Up-regulation | - | Fuc-Hpt might be a useful marker for the prognosis of CRC. The combination of Fuc-Hpt and CEA might be a better serologic marker to predict prognosis. The relationship between Fuc-Hpt( Fucosylated Haptoglobin) levels and clinical parameters was investigated in 77 patients with CRC. |
| 22219064 | 2012 | Cell line : - Source : - Sample Type : CRC tumor and control tissue No. of Sample : 213 Stage : TNM Stag I-IV | Immunohistochemistry, cross-validation method and an independent test set. | Up-regulation | - | Upregulated in colorectal cancer liver metastasis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Chromosome | 16 |
| Location | 16q22.2 |
| Start | 72054609 |
| End | 72061056 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 6448 |
| OMIM ID | 140100 |
| HGNC ID | HGNC:5141 |
| Unigene ID | Hs.513711 |
| Ensembl ID | ENSG00000257017 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_005143.3 |
|---|---|
| Exon | join(1..49,1553..1635,1922..2023,2784..2858,3646..3747, 4506..4580,5504..6448) | mRNA Sequence | Download Select all |
| Length | 1461 |
CDS Information
| Location | join(45..49,1553..1635,1922..2023,2784..2858,3646..3747, 4506..4580,5504..6282) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS45524.1 |
Protein Information
| Protein ID | NP_001119574.1 |
|---|---|
| Protein Name | Haptoglobin |
| Molecular Wt. (Da) | 36596 |
| Protein Sequence | Download Select all |
| Length | 347 |
| Uniprot ID | P42575 |
| Ensembl Protein ID | ENSP00000312664 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| N | Glycosylation | 184 |
| N | Glycosylation | 207 |
| N | Glycosylation | 211 |
| N | Glycosylation | 241 |
| R | Proteolytic Cleavage | 161 |
Enzyme Information
| EC | 1.11.1.7 |
|---|---|
| Name | peroxidase lactoperoxidase guaiacol peroxidase plant peroxidase Japanese radish peroxidase horseradish peroxidase (HRP) soybean peroxidase (SBP) extensin peroxidase heme peroxidase oxyperoxidase protoheme peroxidase pyrocatechol peroxidase scopoletin peroxidase Coprinus cinereus peroxidase Arthromyces ramosus peroxidase |
| Class | Oxidoreductases; Acting on a peroxide as acceptor; Peroxidases |
| Sysname | phenolic donor:hydrogen-peroxide oxidoreductase |
| Substrate | phenolic donor; H2O2 |
| Product | phenoxyl radical of the donor; H2O |
| Reaction (IUBMB) |  |
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 933 | CD22 | 114 | NP_001762.2 | in vivo | 11967116 |
| 3684 | ITGAM | 411 | NP_000623.2 | in vivo | 11967116 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00190 | 162-402 | Tryp_SPc |
| cl21584 | 162-402 | Tryp_SPc superfamily |
| cd00033 | 33-87 | CCP |
| cl00043 | 33-87 | CCP superfamily |
| cd00033 | 92-146 | CCP |
| cl00043 | 92-146 | CCP superfamily |
| smart00020 | 161-399 | Tryp_SPc |
| pfam00089 | 162-399 | Trypsin |
Ontology Information
| HPRD ID | 2800 |
|---|---|
| Molecular Class | Transport/cargo protein |
| Molecular Function | Cysteine-type peptidase activity (GO:0008234) |
| Biological Process | Apoptosis (GO:0006915) |
Drug Information
No matching records could be found.