CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
HPGD	3248	Hydroxyprostaglandin dehydrogenase 15-(NAD)	4	PGDH; PGDH1; PHOAR1; 15-PGDH; SDR36C1

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
15542609	2004	Cell line : - Source : Jackson Laboratory (Bar Harbor, ME), ATCC Sample Type : - No. of Sample : - Stage : -	-	Down-regulation	-	15-PGDH mRNA and protein levels are significantly reduced in human colorectal cancers relative to normal mucosa. Loss of 15-PGDH function in vivo markedly decreases metabolic inactivation of PGE2.
24760190	2014	Cell line : - Source : - Sample Type : CRC tumor and control tissue No. of Sample : 270 Stage : TNM Stag I-IV	-	Down-regulation	-	15-PGDH expression level in normal colon mucosa may serve as a biomarker that may predict stronger benefit from aspirin chemoprevention. Hydroxyprostaglandin dehydrogenase 15-(nicotinamide adenine dinucleotide) (15-PGDH, HPGD) is down-regulated in colorectal cancers and functions as a metabolic antagonist of PTGS2.
23960441	2013	Cell line : - Source : Asan Medical Center (Seoul, Korea) Sample Type : CRC tumor and control tissue No. of Sample : 32 Stage : -	real time RT-PCR	Down-regulation	-	15-PGDH in normal-appearing colorectal mucosa can be a useful biomarker of field effect for the prediction of sporadic synchronous neoplasms.

Gene Details

Chromosome: 4; NC_000004.11 (175411328..175444049, complement)
View Larger Image

Gene Type	protein coding
Gene Family	Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 1
Description	This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Chromosome	4
Location	4q34-q35
Start	174490177
End	174522898
Strand	-
Gene Sequence	>gi\|568815594:c174522898-174490177 Homo sapiens chromosome 4, GRCh38.p2 Primary Assembly GCTTTATTGTTTGCTTGTTTTGTTCCGGAGTCGGGGCCGGGAGGGAGTGCAGGAGGAGGGATCCAAGCTT CCAAGCCTCTGCTCCGCTCTCCTTCTATCCAGTTGGTCTTTAGGGCACTGAAGGAAACTCTTCTTCAGAA ATAACCTTTTAACTTTTCTTCTGTCAGCTGCCTGCCAATCACGGAGCCAGAGGCTGAGGGGAGGCTTTGA GCCGGTCTGCGAGTCCGGAAGGCAAAGATCGCGAAGCTTGGCGCTCCAGAACGCTCAGGGGGCAGGTGAC ACAGTCGTGGGTTCCCCGGCGGGCGCTGGCTTGACAGTTTCCTCCCCGCCCACTGGCAGGGGAGCGCCCC GCCGGGCTGCACGCGCGCGCGCGCAGGGGGGCATAAAAGCCGCGGCCGCGCGGAGACGCGGAGCTCGCCC ACCGCCCGCCCCAGCAGTGGCTGCACCATGCACGTGAACGGCAAAGTGGCGCTGGTGACCGGCGCGGCTC AGGGCATAGGCAGAGCCTTTGCAGAGGCGCTGCTGCTTAAGGGCGCCAAGGTAAGCCCGGCGCCCAGCCG CGGAAATTTCTCTGCCCACACACTCCGAGACTCGCCCCGCCGCCCGAGGTGCACTGGCGGAGACAGGGAG GCCGCGCCCGGCGTGCCCACTTTGCCACTTCCAAAATTTGCTGAAGCTGAGGCTGTGAGCACACCTCAGA AGTGGCTGGGAGGGAACCCAAACCTAATTGCCAAATTTCAGGTCCAGGAGGGGAGCCTCTTGTGTGTTTA TTGTTTGTCCGTCTATTTCGTGAGCTGCGCAGGCCCGCGATTCCTCTCCTCTTGTCTATAGGTAGCGCTG GTGGATTGGAATCTTGAAGCAGGTGTACAGTGTAAAGCTGCCCTGGATGAGCAGTTTGAACCTCAGAAGA CTCTGTTCATCCAGTGCGATGTGGCTGACCAGCAACAACTGAGAGGTAAGACAGGGGAATCAATCTGTCA ACTGGGAACGTGCTCTCAACAAGCAACAACCTGAAGGCAGCCCGGCCAGGGGGCCCTGGGTGCCGCCTCC GCTGCCTCCTCGAGAGCAGCTACCTTGAAGCTCCAAAAGACAGTTTGGACTGATACGTTTCCTTCTGACA GCCCAATAGCTGTAAAACCGAAAGAAAGGCAAGACTGCTGGAGAAATCCTTTTATTGTAGTCATTTGGCA GCATTAATGTAATCAAAATTCCTTTATGTATTCAAAGACAGTGCTGCTGCAGTAATTATTAAATGATTGA AATTGCAGACAAAACTTGGAAAATTAAAGTAGGTTAAGTAAGGTACTGTTGACAAACAACTTCTCCCAGA AAGCTGGAGTCCAATGACAATCAAATGTGGCAGTGTTTTTCGTTTAAACATATCAGAATACAAGTTCAAG GAGCATCATCACAGAAGTGCTAGATGCTTTTGACCATATGTTTTCTCCGGCTTTTTCCCCAATGAGACAG TACTTTAAAATAATAATAATAGTAATCATAATAAAGTATACAATGTTAGAATTGTAGTAGAAACATCTCT ATCAGCCTTTCCTCAATGCTTTCCTGTTTCCGGCTACTCACTTAAAATAGACCAATCTACTTGTGAAGTA TCAGGGACAATATTGGCATACACAATAAACAGCTTTGATTATAAAGCTGTTTTTTTTTTTTTTGTACATC TATTGGAGAACTTGAGAGTGCCCCAATAAACTTACAGGAAACAAAAATTCTGGAGAAAAACTAGAAAAGT AAAATATTTGTATTTCACAAAGTTTTATTCAAAGAGACTGAGTAAATTGTAAGGCACTTTTTAATCAAGG GGTCTGAAAACTTTTGCAAATCTTATTCCAGTGCTCCTGTTCTTAAAGGGACATCAAATGTACATTTATT TTAAAATTTTAAAATATTCTGTAAGAGAATGAAAATGAACTGACGTGTTAGAAGGAAGTGGTGTACCAAC AGTTAAGAGAAATTGTAAAGGAAATTACATAACTGAAATCTGAAAATGCTAATAAAGACCTATAACACAG ATGACAAGCATGAGCAGAACAGATTTGTAAACACAATGCAAGAGGAACATATTGTACCAGAGGACAATTA TGTTGATTGCACATGATATTTTGGATCAAGGATAGAGCCAGGTCAGATCTCAACATTCATGCTGATGGCA TAAGGAACAGTATAAACAATCTGAAAGCCATTTCTGTCTCAATTTATATAGTTTCATAAATGACATTTAA CTACAATTGTTTTTTTCCCAGTATTTAAAATTAATACCTTGGCTATAAACTCATTCCTTAAGGATAAATG ATTGTGGAGGAGGAAAAATACTCAGACACATAAGTGACCCGGGAAGGCATGTTGGTCATGAGAAATCCAC ATGTTGTCTGGACATGAGCATTTGCTTGCATCTAAAGGAAACATGACATTGATTCTTCCAGTTTCAGGAT TTAATGTTGCCTATAACTTTTAAAATTGTTTAGACAGTGTGGAAATTATAAAAATATGAGATGAAAAGTT TCTTGGAGATAATCTAAACATAACTTATTTTCCAAATGAACAAATCACAGCCAAGAGAGTTTAGGTAAGT TACAAAGAGTACCATAGCATATAAATGTCAGCAAGAGGTAGACTGTCTGTTGCTTGAGCCTGGAATTCAA TGGGATGTCAGAAAACAAGATGGTATACTATACATTGGTAAGGGCAGAGTATAAGGAATACGGTGGAGAA CAGAATGAGGAAAGAAAATTAAAGCGGCAATTAGACATACATATTTAACACCCTCATTTTCCAAAAGGTG AAGGTTGTTTCTGTGGAGTTATGAAGAGTTAGAACATACTCAGAATGGAAGGAGAAAAAAAAAATACTGG GGGACATTTTCTGGACCCAATTTGAGATTTTAAGAAACATTTTTAAGATTCCATGAAAAAAGGCCGGGTG CAGTGGCTTCACGCTTGTAATCCCAGCAGTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATC GAGACTTTCACTCGCGTCTGTGTGAAGAGACCACCAAACAGGCTTTGTGTGAGCAACAAGGCTGTTTATT TCACCTGGGTGCAGGCTGGCTGAGTCGGAAAAGAGAGTCAGCAAAGGGAAATAGGGGTGGGGCTATTTTA TAAGATTTGGGTAGGTAAAGGAAAAAGGGGGGTTGCCCGCTGGTGGGCAGCAGTGGGGGTCACAAGGTGC TCAGTGGTGGAGCTTTTTGAGCCAGGATGAGCCAGGAGATGGAATTTCACAAGGTAATGTCATCAGTTAA GGCAAGGACCGGCCATTTTCACTTCTTTTGTGGTGGAATGTCATCAGTTAAGGCAGGAACAGGCCATTTA AGTATCACTACTTTTGTGATTCTTCAGTTACTTCAGGCCATGTGGATGTATATGTGCAGGTCACAGGGGA TATAATGGCTTAGCTTGGGCTCAGAGGCCTGACAGAGATCATCCTGGCTAACACGGTGAAACCCCGTCTC TACTAAAAATACAAAAAATTAGCCGGGCGTGGTGGTGGGCGCCTGTAGTCCCAGCTACTCTGGAGGCTGA GGCAGGAGAATGGCGTGAACCCGGGAGGTGGAGCTTGCAGTGAGCTGAGATCAGGCCACTGCACTCCAGC CTGGGGGACAGAACGAGGCTCCGACTCAAAAAAAAAAAAATCCATGAAAAATAAACAGTTTGTGTTTGTT GTTCTTCCATTCCCGTACAGTGAGTGTAAAAGGTACATATTAGGAAATCTTGAAAATGTTTTTAGTAAAC AACTAGCATAGTAATTTATCTATATGGCAACTGATTAATCCATGTCTTCCCCAATATGTCTGGTGGTTGT TAATGATTATATGAATTTATTTCAATCAAAATAAAGCTTATGCTGACCTACTTTTTTTAAGGACTTGATA TGTTGGTCTGGACACCTGAGAATATATTTCCGTCATGTAGAAAAACAACCACAATTTTTATCCATAGTGT AAAATAATAGAAGTAGAATGAATGATCAAAGGCCCGGGGAAACAGTTTAAATCAATTAGAACTCTGTCAA AGGCTGCTTTGAGAAACAATAGACATGTGATTGGACAGTGTAATGAAAGACATTCAGGCCTCAGAATCCA TGCCAACTTTATCCTGTTTGAACATAGTTTTATACAAACTAGTAATCCTAGTAATCTGAAGTAGTAATAA TAGTGAGAAAGAAGAAGGAAATAGTAAACATCGAAGTTTCAGTAATCAAATAAAATCAACTGAATGAAAA GTAGACTTTTACTAAGATATAAAAACTCCCCCAAACATGCATAATAGATCTGAATACACAAGAATATTTG TATTAACATAACACTTTATGAATTTAATATGGCTTATGGAAAAGGATGTTTACCAATAGTCTAAGCTACA GAGCTTCAGTAGCTTCTCAGGGACTAAGAGACATTGCTTGCTCTAACTGACTTCAACGAGCTCTTAGCTT AGGATCTTAGCTCAGTTCTCTAAAATGTACCCCATTAAGTTACTGCTTATAGAACTTCAATGTGCATACA AATCATGTAAGAATATGTTAAAGTTAAGATTCTTATTCAGTTAGTCTGTGGTGTCTGCAAAATTCTGCAT TCTTACCAAGCTGCCAGATTGATGCTTCTAGTCCACAAACCACACATTGAGAAACAAGGAATTAATTACA CTCAGCCCATGAGTTTAGTAACTTTCACTATGAGGGTAAATAAACTGAAATTCCTCTCATGGCATAGGAC ATGATTTAAATGTATACATGGAAAATAAGAATGTATCACTAATATCTTGTTTTATAATTAGACACTTTTA GAAAAGTTGTAGACCACTTTGGAAGACTGGACATTTTGGTCAATAATGCTGGAGTGAATAATGAGAAAAA CTGGGAAAAAACTCTGCAAATTAATTTGGTGAGTTATCTTAGCTATATTTCTTGTCTATAATTATTTAAT AACATGATGTTTGTAAAGAAAAAAAGGTTCTTGGAGTCATGGAAACAAAACAATGACCTACAATATTGAA AAAGGGAAGTTACAGAAAGCTGGATAAAAGCATTTTCTTTTATAAAAAGGAAGACATTTAATTATGAAAG TAAGTCTATCTTAAAATATTAGAAAGAAGCATGAATAAAATATAAATGATTGCTTAACTCAGGGATTGGC AGACTATGACCCACAGGCCAAAATAGCCTGCCAACTCTTTTGGTATGACCTGCAAGCTAAAAATACCATT TTACATTTCTAAATGGTGGATAAATTCAAAAGAAGAATAATATGATTATATGAAATTCAACTTTCAGTGT CCATAAAGTTTTATTGGAACACAGCCACAGTCATTCATTTAAGAATTGTCATTGGCTATTTTCATGCTAC AGGGGCAAAGTTTAATATTTGTAAAAGATCCTGTGGCATTCAATGACTAAAATATTTACAATCTGGCCCT TTACAGAAAAAGCTCGTCAACCGCTGACTTATTTATTTAAAAGTAAATCTTAATTAAATGCTAGAATGTA ACAGAAAACAAAATTAAAGTGACAATCGAACTTTGTAATTAGTAGGACTTTTTATCCTGAAAGTTCGTGG TTCGTGTGTGTGTGTGATTTCCATAATGTTTGATAATGACTTAGCTCTTAAAAATGGTAGAATTAAGAAA TAAAATTTTCTCTTTTATCCATTAAGTCATGAGTTTATGGGTTACCTCATTCTATAAATACCCTTGACAT AAGATATTGGAGTTTAGTAAAAATCAAACGTTAACTAAAACTAAATGTCAAATAGGCTGTGCCTGGGGTC TCCCTGACCTTGCTAAGGTCATTCTCACCAATCTTACAAGGCAGGTAATTGTAGAGTACAATTTGGCCAC TGTGTATGTATAAAGGTACAGGGAGTGACCTCCTACTTCATGATATCCTCCTAGTAGATTATAAACTCCA TAAAAACAAGAACTGGGTTGTGTTTTTCTTTGTCTCTCTCTCAGTAATCAACATAATATCTTGAAGATAG TGCTTAGTCAATACATTTTTTACTTAAATTGAAATGCCCATGAGTAATTACCTAACTGCTATAATAACTT GATAGAGGCAATGAGGATGACACTTCTTCACAAAAGAGCCAAATCTGTAAGTCCTACCTTGAGAAGAGTA CAAAATTGCTCCCTAAACTTGACAGATAACTAAAATACAGTTTTCTTTTAGTTTTTTAAATTTTTCAATT ATTTTTGTTGGCTTTTCTTTTCCAACTTTTATTTTAGGTTCAGGGTGTACATGTGCAGATTTGTTACCTG AGTAAATCGTGTGTCACTGGGGTTTGGTGTACAGATGATTTCATCACCCAGATAGTGGTCATAGCAACCC ATAGATAGTTTTCCCACTCTCACCCTTCTCCCACCCTTCATCCTCAAGTAGACCTTGGGGACTATTGTTC CCCTTTGTATCCATATGTGCTTAATGTTTTGTTCCTGTTTGTAAGTGAGAACATGAGGTATTTGATTTTC TGTTCCTGCATTAATTTGCTTAGGATAATGCTCTCCAGCTGCATCCATGTTGCTGCAACCAACATGATTT CCTTTTTTATGGGTGTGTGGTGTTTCATGCTGTATACCTACCCGTATTCTTTATCCAGTCCCCCGTTGAT GGGCATCTAGGTTGATTCCGTCTTTGCTATTGTGAATAGTGTTGCGATGACCCTATTAGTGCTGTGTCTT TCTTGGTAGAATGATTTATGTTCCTTTGGGTATATACCCAGTAATGGGGTTGCTGGGTTGAATGGTAGTT CTGTTTTAAGTTCTTCGAGAAAAGCTCCAAAATGCTTTCCATGGTGTCTGACTAGTTTACTTTCTTACCA GCAGCATATAAGTGTTCCCTTTTCTCTACAGCCTCGCCAAGCCAACATCCATTATTTATTTATTTTTTAC TTCTTAATGATAGCCATTCTGATCGCTGTGAAATTGTATTTCATTGTGGTTCTGATTTGCATTTCTCTGA TGATTAGTGATATTGAGCATTTTTTATGTTTGTTGGCCATGTGTCTGTCCTCTTCTGAGAAGTATTCACA GAAGTCTCTTTATGTCCTTTGCCCTTTTTTTAATGGGGTTGTTTGGTTTTTGCTTGTTGATTTGCTCAAG TTCCTTATATAATCTGTATATTAGACCTTTGTCAGATCCATAGTTTGCAAATATTTTCTCCAGTTCTGTA GGTTATCTGCTTACTGCTTTGATAGTTTCTTTTGCTGTGCAGAAGCTCTTTAGTTTAATTAGGTCCCATC TATTTTTGGTTTTGTTGCAATTGCTTTTGGAGACTTCATCATGAGATCTTTGCCATGGCATGTCTTCAGA ATGGGGTGCTTTGTGTTTTCTTCTAGAATTTGTATAGTTTTAGGTTTTACATATGGTGTAAGGAAGGGGT CCAGTTTCAATCTTCTGCATATGGCTACCTGGTTATCCCAGCACAATTTATTGAATAGTGCATCCTTTCC CCATGCTCGTTTTTGTCAATTTTGTCAAAGATCAGATGATTGTAGGTGTACAGCCTTATTTCTGGCTTCT CCATGCTGTTCCATTGGTCTATATATCTGTTTTTGTACCAGTACCGTGCTGTTTGGGTTACTGTAGCCTT GTATAGTTTGAAGTCGAATAGTGTGATGCCTCCAGCTTTGTTCATTTTACTTAGAATTGCTTTGACTATT CTGACTCTTTTTGGATTCCATATGAATTTGAAAATTGTTTTTTTTAATTCTGTGGAAATGATGATGGTAG TTTGATAGGAATAGCATTGAATCTGTAAATTGCTTTGAGCAGTATGGCCATTTTAACAATATTGATTCTT CCTATCCATGAACATGGAATGTGTTTTCATTTAATAATGACATCTCTGATTCCTTTCAGTAGTGTTTTAC AATTCTCATTGTAGAGATCTTTCACCTTGCTGGTGAGCTGTATTCATAGGTATTTTATTCTTTTTGTGGT TGTTGTAAATGGGATTGCATTCTTGATTTGCCTCTTAGCTTGGACATTATTGGTGTTTGGAAACATTACT GATTTTTGTACATTGGTTATGTATCCTGAAACGTAACTTAAATTGTTTATCAGTTCTAGGAAACTTTGGG CAGAGACTATGGTGTTTTCTATGTATAGAATCATACCGTTTGCAAAAAAAGATAGTTTGACTTCCTCTCT TCTTATTTAGATGCCCTTTATTCCTTTCTCTTGCCAGATTGCTCTGGCTTGGATTTCCAGTACTATGTTG AATATGAGTGGTGAGAGTGGGTATCCTTGTCTTGTTTCAGCTCTCAAGGCGAATGCTTCCAGCTTTTTCC CACTCAGTAAGATGTTTGCTTTATGTTACTTCGATGCCTATGTTGTTGAGGATTTTTTAACATGAAAAGA TGTTGAATTTTACCTAAAATCTTTTAATTAAGAAGGAAGGTTCTATTTTACAGTATGGATACCCTCCTTG CAGTTCTTTTAAAACTTTTTCTCCAGTGTACCTCTTTCATTATATTTGAAAATAACTTGAAACTGTCAAG CTTCCCTCAAAATCTTTTTGGGATTCTAATTGCAAATATACATACATGTGTTTGGAGAGACCTGATAGCT GATTTTCCTGAGTTGAGACAGTTCTGTGATCTTCTTCTACTTTAGGGTAGAAATGTATTGAAATGAGATA TTCTGTCTGTGAATCATACTTACATCTCTTGGCTAAATCTTCCATTATTATGATATATGAATGTTTAATA TACCATTGAATTTTTTTAATTCCTAATTTAGTATTTGTGCTTCTGTACTTATAAATTGTACTATCCTTAA TTTTCTTTTCTTATAATGTTCTTATTTGGTTTGGGTGTCATCTATATCCTGGCTTCCTTTTATGTCCTTG ATCTGTTCATTTCTCAACAGAGGCATTCTTATCTCAAATGGCAAATGGCAGTCTGCCTACCTCTTTTAGT AATTCTGTAAGTTTAGACTCTATATATTATAAATCTATAATATTCAGAGCATAAGTTGCTAATGATTGCA ATTTATTGATTTTTAAATTTTTTTTAAAGTTAAACTTCTGATTTGCTGTCTGATGATTTTTTAATCTATT CTATATTTTCAGATATAAAATTAGTACCCTATCATTTTCTTTGGATTCACATTCACCTACCTTTTTCCAT TACTTTATTTTAAAAATATAAGCAACCTTTTATGTTAAATTTGTTGTTGCTGATGGTTTATTGTGAGATC TTAGAATCCTCTAATCTGTAGTTAGACACAACTGGGAACATCTGCCTTTTTAATATTTGTGAGTTTAAGC CATTTATTTTTACTCTTCCGTTTTATACTTTAATATTTACTGTTTTCTTTTTGTTTTTATTCTTTTTCTA TTCCTTCCCTAAATGCATTATATAGCTTTAATTTTCTTATGCTGGTAAAAAAAAAAAATATGCATTTTAT ATTTACTCTTTGGAGGATACCCCTGACTTATTAAGAGTTGTATTTCATTACATCTTTTGGTAGCCTGATA AAACAAAAATTTTGAAAATATGGCTAATTGGGAACTGCAAGGATTTTTAAGAATATAGACTCATGCCACT TTCCAAAACCACATTAAATGACGAGATTTTCTTTGAACCAGGCTATCCCAGTGAAAAAGCACAAATTGCA CAACAGCTTTCTCTCTTTAACATTACTACTGATATTTGTAATAGCTTCATCGGTAATATCTACAGATATT TTTACAGATAAAATTAATAGAGTATATAGTTCCTGTATTTGGTGACTTCCTAATGGACACTTGCTGTGTC TTTTCTCTGAAAAATCAGCTGTCAGAAACAGTGTGCAATGATTACAGCTAACGTAAAGAAACATGGAAAT ATTGAGGCAAATATTACGAAGTTACAGAATTCGACTGATGTCTTCATCCAGCTGAGAGGGCATGTTTGCT TTAATGTAGCCTGTGTGAATACCTGCTCTGAGCTGGAAAGTGCCAATATCATGGGCAAATAGGAAATTCT GGAAGACCAGGGGAATTTTATTGTGATCCTTTAGTTATAACTAACAGGCCTAGTTCCTTCTCCATTGAAA TTTATCCAGCCTTTATTTTTCTTGGGACTCTGCTGACATAGGCCACTTTTCAGCTTCACATCAGGAACTG ATGATATATGTTTACATAAAGAAAACACCATGGAACCTTTGTTACCAATGTATTACTTAAAAATATGTTA CTTCCCCTCCTACCTAAACCCGTTGCAAGAGTAGAATCTGACCAATAATTTAACTTCCAACTTGATTATC TCTGTTACTGTAATGCAAATATTTGTGTGTAGTTTATATAACTCTTTTTTGAAACTCTGCTCTGGATTTA ATTTGCCTCCTTGGGTCTTATACAATTCCATGTTTGTTCTTTTGCATGTTTTTCTGTATTACTGCTCATG TCAGAGAGTAACCTCTTAAAAGACTTTACCATATATCTCTCCTTCTTCTAAAATATTATACAACATATTT ATACCATTTTCATAGGGCTTACCAGTTTTTTAATTTTATTAGAATTATTTAAATATATACATAATTCATG CTATTCATGCTAGTAAACCACAAGTTCTTTCAAGGCAGAAAACTATTGTCTTGTGTCCTTACAGATGTTA GTTAATAGTTACTGGGTCACCTGCCATTACCTGTATATGATATTTTGCATACATGAGAGTATTCACTTCT ATGTCTCAGTACATTGCTTTCCAAATACATTAGTTCTTCCAAACGGTATCATCTGTCCTTCTACTTTTAC TCCTTATCAAATTTACTCCTTACTTTTCACTTTGCTGATCTCATCCTTCTTCCCACTAAACCTTTTCCCA GTCTTTGGTTTCCATTAGGCTATTTTATACTTCCTCCTTAGTCTGAAGCCAACAACAGCAGCATTATGTA TTGCTGTTCAGAACACAGAAGAAATGTTCAGCAGGCCGGGAGCGGTGACTCACGCCTGTAATCCCAGCAC TTTGGGAGACCGAGGCGGGCGGATCACAAGGTCAGGAGATTGAGACCATCCTGGCTAACACGATGAAACC CCGTCTCTACTAAAAATACAAAAATTTAGCCGGGCGTGGTGGCGGACGCCTGTAGTCCCAGTTATTCAGG AGGCTGAGGCAGGCGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCGAGATTGCGCCACTGCA CTCCAGCCTGGGCGACAGAGCGAGACTCTGTCTCAAAAACAAAATAAAATTAAAAAAAAGAAATGTTCAG GAAAGAATGAGTCTTTGCAAAACTATCAACACTCATGCTGGCAATTGGGCAGAGGTAAACTTAACTTTGA ATATTGATTGGAATGGTAATTCTGTCATGTAGTTTTGTAACTTTCTGAAGTTTCTGTAAACCTAAATATG TTCATCCCCACTGATGTGGAACTTACAGTCTAATTTTGACATTTAACTAATATATGTTGAATTCCTTAAC CCATTTATGCCAGAGGTTGCAATATTTTGAATTTTTGCATGAGTTAAAAATTAGACCTTGGCAATGACCT TGAACAGTAGGATATAAATAACTCTCACGTGCTTAGTATTCCAATAATGGAACACTAGGCATAAGTGGGT CAATATATTCAAATAAGATTTAAACAAAATAAATGAATGTTGCTAGTCATTTTTTTTTTTTTTCTGAAAT GCACTTATTGACTAAAGATTTGCCCTGGGAAATACATTTCTTTGGGATTAGTCAAAATTAGAATCCAGTC TTGACTCTATAATTTATAAACTGTTATTTTATTTCTCTCATATTGAGCTTCCCAGGGAGGAAGGTAAACT CCCTATCTCTAAGGACTGTTACGCTTAAATAAACCATAGTTTATGTGAATATCCAGCACAGTGCCACTGC ATAGAATTTATTCAATAAATTACACTTCCCTTCCAGAGCATCAAAATCTACATTTTCTGGCCAGGCACGG TGGCTCAGGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGCGGATTAGTTGAGGTCAGGAGTTCGA GACCAGCCTGGCCAACATGGTGAAATATATAATATATAGACACACGTGCACATGCGTATATAATCTAGAA TAAGGACTACGTTGTTATAGTAAAGGAGGAAAAGTGAAAAATGTCATTTCTACACAGCCAAAGCATTAGA CCCTGTCTTGTAGATTCATCCTTTGAACTCTTTCATTTGAAAAATTACCCAGTTCTTAACCTGATAATGG ATGAGAAAAATAATCCCTTGCCTTTCTCCACCAAAGACCTAAAGATAAATATTGCTTTTCTAAAAAATTA AAAATAAATCTTAAAAAATCTCAAATTTTCTATCTGGCTTCATCTTGTTCATGTCGAAAACACAACAGTG GGGTGTCAGCAAAGCTGTAATACCTGAGAATAAAAGCGTAGTGCCAATACGCATGAACAGAAATTCTGTT CAGACATGCTGAAGCCTTCTGCAGAAACTAACAGAATCCAACTGGCTTCATTAATTTCAGCCATCTACAT CTTTTTCTTCTTATATAAACAATTAATGTTTTGGTTTTCCTTTCTAAAGAAAATCATGTGGAGATTTTAT TCATTCTCCCTAAGCCTACTTACTGTCAAATTGACACATGGCTTAAGTGAATAGAACCTCCAATTTCCTT TTTTGTTCAAGAGCTACTGTTAGGTAGGAGAAGTATATCTGAATCCTTGCAAAAAAAAGAAAACTTCAAA AGGAAATTTTTAAGAGAAAAAGAAGGTAAGTACATGTGTAACCTCCGTTTCAGACGCATTACCTATTGTA TCGTTTTCTTTGCAGTATTGTAAAGCATGAAAAAAATAGGAATTAAGATGTCAAAAAAGAATTTTCCTTT TTTAAAAGTCTGAGCTGGAAGGGATAGGAATTCTTAAATCCAAAAGGAAAAGTAAGGTTTGAAATATCAA TTTGATCACACAGGTTTTTTTTTTTCTTTTTTTTTTTTGGTAGTGATTTGAACAAAAACAGGAAAAGTGC CTACACATGGATATAAGTGGCAAAACAGTCAACTATCAAAAGGATAGCTGTAAGCAGTGATTAATAAAAT TTAGTTATAGACATTACTAAAGACCAGATGTCCAGCTAACTGACAATCACCACTTAAACTGGATAAAACA TTTATGTGATTTCACACAACACGGAGTTGAGGATTGCTTGATCTTACAGGTCAATGATATCATCGGGCCC AGGGTTGTGTCATCCCTCCCACCGACCATTCTTTATGTTGGTTTCATCTTCAGGATACTAGGAAATAGGG GTTGTCCATTTAAGTTACGACATTCATATAAAGCAGGCAATGTAACCATTTCTTCAGGTTTTCTTAAGAG CAACAAAAAATTTCTCAGCAGCATCCATCCTGTTCCCATCTCTAGCTGATTGCCTCCCAGGTCTCACTGA CCAAAACTGGGTCACCTGCTGGCTCTGAAACCAGCCACTGTCAAGGAGAATGGGATTTCCATGACTGAAT TAAATTAATTAATCAGTGTCTACATTAAATTTGGGGAGATCACCTTCCTCGTATTATATGGAGAGGAGGT AGATACAGGAGCAAAATAGAACTTTTATTAGAAAGAAAAAAGGAGAAAATAAAACCTCTAGGAAATCAAG AGTAAGCATTATTCTATATTCCAAGATCCAAGAGAATTAAACAGAGTAGTTAAGTGTGGAATACTGAGAC ATGAGAACCATATGCAGAGAAGAAGGGTAAATAAATTTTGCATCCAACATTTAGAAAACAAAAAGAATAT ATGGAATTATTGAAGATGTTGAGAATTGAGTGAAAGTAATAGACATTTTTGGAATACAACCTGTAGCATA AAATCTCATATTGGGCAACTAAGTGAAGTTTTGCAGATATATGACAAGCTCCACAATGATTAGGCAAACC CAAAGAATCCAGGTTTAATGACTAACTTTAAAAACAAAGCTCTTTTAAAACCTTTCATTGATAATATTTG CAGAAATCTCCCTAGGTATCTGGAATAGCTATAAAAACTTTGGTGTGTGAAAATATGGGAAAGGATAATG ACTGTATTCCTTTTCTCACTTATGCCTCTGGATTAGGTTTCTGTTATCAGTGGAACCTATCTTGGTTTGG ATTACATGAGTAAGCAAAATGGAGGTGAAGGCGGCATCATTATCAATATGTCATCTTTAGCAGGTAAGGG CAATTATTACATTAAATGTAACATTTTCTTACTGGTAATTTGGACCACAAAAACAAATCTTCAAAGCATA TTTATTATCAGCTCAAGTTGGAAATTAAAAATCTGATCGTTTTATAGTTCCATGGAATTTTCTATTGCAA AATATCAAAAGTTTGAAAAATATGTTTATTTCTCTTAATTTAACTTGTGGCTTTTAAAGTTATCTTACTG CAGTAATATTTGAAAAAATATATATAATTTTTTTTTAGAGCCAATATTTTTCAAAGGTTGTGGTGAGACT CCTAAGCAATAATGCATGTGAAAGCACCTTTGGCAAAGTAAAAAGCACTAAAGTGAAGTTAAGATGTCTC TGCTCCCATGTGATTTTAGTAACAGTGTGTAATTTTAAAATATGGCATATATCATAGTTAAGATATGTTA AACTAATAAATAAAGCCAAACTTACATGTAGTATAAGCACATTCCTTAACTCGTACATCAGTCTGAGGCA AGATCCTTGTTGCAGGTATCTCTTCTGTATGCAGACATTTGAAAACCTGGCTGGCAGAAGTTCTGCCGTC TTCAGCAGGGAGCTCCCAGGGTTACTTTAGAACTGCTGGATTCCTTTTTCTCTAGCAGAAAGAGAAGAAG AACATGGAGGAGGCATGGCTACTCTTTTAAGAACCCCAGCCCAGTAATGGCAGACCTTCTGCTCACATTT CAGTATAGAACTTGAGCTCATGTTTCACCTAACTGTAAGCGAGTCTGTCTGGGAAATGCAGTCTAGCTGT GTGCCTAAGAGAAGAATGGATTTCAGAGGGCAGCTAATCATCTTTTCCACAGCATGCAATCCTAAACTAT AGTATTTTCAGAGTAGTATGATTTAGTATCAGCTGATATCTTATCCTTCAATACTAGCCTTAAACCTCTG ACTGGACTTTTTGGAGCAACTGAGTCAAGTGACTTTACTTTTTAAAACTCTAGGAAAAAATCATCAATGA TTCTTGAATAGTTCAAGTGAAATTGTGAAGTTTAAGAAGTCTGATCAACATGGACAGCAAATCTAAGCTA TCTTGTCCAAAAAAGTGAGACTTTAAAAAATTATCTGTTTGGTTTTAGTTAATGTGGTGATTTCAGAATA GAAATTTCAGCCCCACACCCCACCCCAACCTTGGCATCTCAGCTCCAGTGATTTGGGAAGTTGGGTTTGG AGGTACCTGTGATTGAACCTCTGTCTGATTCTCAGCATTTGTCTCATCCCTCTAGGAATGATTATCAAAT GGTTCTTTTATATCACTGTAAAGCTGCCACCAGAGGAGATTTAGAAATCTCCTTTAGAAGTTCTCAAAAA TAGACTAGCATCTCATTTTCTGGGTCGCTTAAAGTCAAAATCATGTCCCTAAAGCTATTACAAACCTATT TCTATAAATTTTTCAGGGTAATCAGATTCTTTTTCCTAGTGGTACAACTACTTATAAATTATAACATTTT AATCCTAATGATACTTTAAAAGGTGAGCGCACGGGCAATATTTGAAAGGGGTATGTGTTCCAGAGAGGGC CAAATGTTAAGCTGTGGGAGACTGAAACCCTAAAAGCAAATTGGCAAAGCTAAATCTATACTATTTTGAA ATAAAATCATAAGAAAAAAACAAGTGACTGGAGAATTAAAAAGAGATATTTAGTATTTTCTTAAAAGTTT AAATATTTAAAAACCTGGGGCTGTGATCAAGATTGATAATTCTCTGTATTCTTTCATAAAGCTAAGAGGG TCAGCAAAGCTTGGAGTACCATGAATATTCTACAAGGAGCCCCTGGCCTTTATGTCACTGGAGGCACTGA TTTCATTCTTTGGAAGGCTGAAAGCCTCAGAGTTGGATCAATTTAGGACGATCTGGGAGAAATTCTTTAC CATAAGAGGGTGCTTCCTTGCCCCAAAGAGCATGAATAAAGAAATGCAATGTAGAATTACTGCCTTTTAT CTGTTTAAAATATTCAAATATATAATATCATTTATTGAGCACTGTTTACCTGATATCATTTTAAACACTG TACATTAACTCATTTAATCCTCACAACAACCCTGTGAGGTAAACTCTATATAATTTCCATTTTGAAAATG AGGAAACTAAGGCAGGAGAAGTGTGAAATATCTTGCCTAAGCTTATACATCAAGTAAGCCTCAGAGCTGG AATTCACATGCAAATAGCCTGGTACAAGTCTTCTTAGAATTTTAACCACTAGATTATTTATCTATCTCTA ATATCTATGCATTTATTTGTTAATCTACCTGTATTTATCCCAGCCTAACAGAAAAGTAAAAGCAACTGAA ATCGTTTCAATTGAATAAACCCTTGCAATTTGCTAGTCTCTTCAGGCTTCATGGGCACAGCTCTAATCTC ATGGCTGCATTACTAAACCTTCAGTGAAATCTTAAGCTTTTGCCCCATTTGATACTTCCAGTAAAGTCCT AAAAATATCTGGGGAGCTTACCAGTGTCACAAGTCAAAACATGCCATTGAGCAGAGCAGTTTAAGGCTTG CAATTTGATGTCCACTTTGCTTTGTTGGCTAGGAGCTTGCTTTGTCATCCCGCTCACCGCCACCTCCCGC CAACCCCAGGTGTTAATCCTCTTTTTACCTATGTCAGATACAACATTTGCAATCATGTGTGGGCATTTCT CTATTCATGCAGATAAAACGATGACTTGATATAAATTCAGTGATAAGATTGCTTTGGTTTTAAATTACTT TCCTGGCACTGGTACAATTTAATGAATAATATTGCATTACAAACTGCTTCTCCCTCTGATTTTCCTCCAC ATGTACAAGGCAACACTATGTAAAATGGTTAAATAGCTTAAGTTTGTCATTGTTCCCTCTGCTTGGCTTA CTACTCTCTCCATTTTCAGAAGTTGTCCTTGGCACCCTCTCTTCGTAATTCCAGCCTCCGCACCTCTTGT GTTTATACTGTTTCCTCGTTGCCACTGGCCAATGTGGACAGTCTACTTCCTTTCCCATCCAGGGCTCCCA CTAACATGCCTTCAACTCACAAAGTCTTAAAATGAATTGCCTTGTATTTTATCCACCAACGGAGAGCCTC CAATTCTTCCCATAATGAAATTAGTTTGATAAAAATTCAGGATATTGTAATAATGGGAGAAGGCAAAAGA GGACCCCTCCGTCTTCATCATTCCCTCAGAAATGGTATCAACAATTTTATGCCCTTGAGTCATAGCATGT AGGAAGAGGTGAGAGCACAAAAATAATCTTTAAGGAGTTAACAGAGTACTTCTAATATTTGCCTACTCTG TGTTTTCCAAACCTTGCTTCCTCACAGATTTTTTTTTCCTGTTTTTCTCTGTACTGCTTACTCTATTGAA GGAATGGCTGTGGGTAATATTCAGTATTCAACTCAACAGGGCCTATCCTCATGATCTCTAGCGTGGATAC AGTGGAGTCCTTCACTGTCACAGTAAAACCTTAAGTTGGCACACTGGTTTGAGTAGAGAAGTTAATGAGT AATGACCACTGACGCAGACAGAGTATCAAATGCAATTAATAGGTTTAATAAACAGGAGTAGTTAAGTAGA CAATGATTCCTCAGCAGATTATGGGATGGGTATGCTCTAGTCTGGAGTTCCACAAGTTGTTCTGAGTGTG GTTAACCCACATGGACTTTTCTACACGAGTTTTTATTTATAAACATAATATACAAACAGACACTAATTTT GCCACATCCATCCTGAACTATTAAAACAAAGTTGGAAGGAACAATAGAAGAACGAAGTCTGGTTTAATGC AGATAATCAAACAGCTATGCTCCATTAAAACATCTCATGAGTCAAATGCACTCCGTTTGTTTGTTTGTTT GTTTGTTTGTTTGTTTGTTTGTTTTGAGACAGAGTTTCACTCGTGTCACCCAGGCTGGAGTGCAATGGCG CGATCTCGGCTCACTACAACCAACACCTCTCAGGTTAAAGCAATTCTCCTGCCTCAGCCTCCCCAGTAGC TGGGATTACAGGTGCACACCACCACGTCTGGCTTTTTTTTTTTTTGTATTTTTAGTAGAAACGGGATTTC ATCATGCTAGCCAGGCTGGTATCGAACTCCTGACCTCAGGTGATCTGCCTGCCTCAGCCTCCCGAAGTGC TGGGATTACAGGCGCAGTTCTTAAGTATTTAATTGCTTCAGATTGTGGGAAAGGAAAAGTTATTGTCACA GGAAAAGGAGCCTACCTACCAACCCTGCTACATATTCAGTTAGTGAGGCTGTGGTGTTCACTAGGGACAT GCTCTGTCACTCAGTAGCATTTTGTGAGAGATACCATGAGGGTCTTATTTACTCAGAAGTCAAAACATTG GAGTCTCCAGAAAATATTTAAAAATCATACAAAATTTTCAGCATGTCTTAAGTAACAACCCAGTGGCATA TCTGCTTGTGCTATAAGTTTTATCTATAATAATATAATTAGCTCATAATTTGTGTTAAGGTAGAAGTGCT AAAATTACTACCTTAAATAAAAATTTCAACTTAATCAAACATATGTTGAGCATTTGCAGAAGGGAAATGG AGATATTAAAGTAACTAGGCAAAGTTTCTACCCCAAGAGCTGTATATCAGTGTCTCTTATCAAGATGACA GAACCAAATAATTTCCATGACATAAACTGTTTAAACAGAAGCATTGGCCAGGTGTCATGGCTCACACCTA TAATCACAATGCTTTGGGAGGCCAAGGCAGGAGGATCACTTGAGGCCAGGAGTTAGAGACCAGCATGGGC AACAGAATGAGACCTCATCTGTATAAAAATTTTTAAAAATTAGCTGGGTGTGATGGTGCACACCTGTGTT CCTAGCTACTCAGGAGGCTGAGGTGGGAGGATTTCTTCAGCCTAGGAGTTCAAAGCTGCAGTGAGCTATG ATTGCACTACTGCACTCCAGCCTGGGCAATATAGTGAGACCTTGTCTCTCAAAAGAAAAAAAAAAAAAAT CAAAAAACCCAGAAGCATGATATTTAAGTTGCAAGGCCTTGGGACTCCAATAGCCGAAGAATGGACTAGA ATATCCAGAAATTCCAGGTGAAATAAAACATTGATCATCTTCTTCTATCTCTGGGCCAAAGGTAAGAAAA TCGCATGGCACCACCCTCTACTACTGCTCTCGTGATAAGGAAGCAGGCCTAACACATATTGAGCAATTGC CAAGCTCCAGGCATTGTGGTAAACTATTGGCTTTATGACATCCACATCTAACTTTTACAAGTCTCTACAA TAGAGGTCAATTTAATTATCTCCAATTTATAGTTGAACAATGAATCTCAAACAGATCTTGAAGAATGTGG GAATTAGCAGTGGTAATAAAAGCAATTTTATTTTGCTCCATTTTAGCCTGTGTCATAGAGTGGATGTACT GTTCCTATGCTGTGATTCATAAGTGCTCAGATGCCAACTGCCATGAGTATGGGAGCCACCCTTCCTGCTT AGTGCTGGCAAAGTTCTCCCAAATGGACTCTGCAGAGTCCATTTTGCTCTCTTTTGGCTTAAAATAGTTT AAAAGACACATAGTAGAAGTAATCAGTAGGAATGATTAAATATTTGTAAATGAGGCATTTTGAAGGATAG ATGAGAGATTCGAGGTTTCTTAACATAGGAATGAGAGGGCTACTGAGAAACGAATAGTCTTCTAGAACAG TGCTTCTCAGATTTAATATGTCTAGGGACTTTGTCAGATGCAGATTCTGATTTCGATAGGACAGAGATGG CTCCTGAAATTGTGCTCCCAGGTGATACCGCTCCTTGAACCACACTTTAAGAAGCCAGCCACTAGTATGC ATAGGGATGGATATTCTTTGAATGGGTAAGGGAGCTTCTGTCAGTTTCCTCTGACCACAGCCTAGGCAAT GACTGAACACTAGTAGCAACTGTCTGAGTCACTAGAAATTGCTATTAAACATATCTTTCTGGGAAGATTT TTGTTATAGAATATATAGTGGTTTTATGAAAGCATGTGTCACTTTTTTTTTTTTTTTTTTTGAGACGGAG TCTCGCTCTGTCGCCCAGGCTGGAGTGCGGTGGCGCAATCTCGGCTCACTGCAAGCTCCGCCTTTCGGGT TCACGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGAGACTACAGGCGCCCGCCACCACGCCTGGCTAA TTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCACCATCTCCTGACCTCGT GATCCGCCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTCAGCCACCGCGCCCGGCCGCATGTGT CACTTTTTAATGTCGTGTCACACTCTAAAGCATAACTTAATGGCACCCATAAGAATGAGAAAAAAAACAG CCATCAGATAAGGTGTTCCATTATGCGGAAAATCACAAATGAGGAAGTTCACCAGTTACTTTGGTCAGGT GTATGCACGAATCGTAGATAAATATTTCTTGCTAGTTCTCCCTTTTTTCTTCAAGTTGGAGAAGTGGTGG TTAAAACAGACAGACGGGTACACATTTTTTTGTTGTTGTTGGTTGTAAAGAAAATGTGACAGCTTTAGAT TCCTGCTTTTTTAGCGTAGTTACAGAACTCCAGGTTATCATACGAGTATCAGCATCCTTAGATTCACCAT TTATTTCCCTAAGTTGAATTTTCAGCATTTTTATATAGTCCATTCTACATGGTTTCTCTCTCCTTAAAAG CAAATCTTGTTTGCGGATTTAGTATGACTGCCCTGTCTGAGGAGGTTTCTGTTTTTGCAAAAAAATCTTT TTGAGCTTTTTTACCTTCTGTGAAATGATTAAAACTGGCTTTTGTAAATATGGGTAGAAAGATTATGAAG AATAGAAGAACTAATGTAGAGATGGAATTTACATTTTTTTTTCTGAATGACTTTCTTTGTTCTATTAGTA CACATGTAATTTTCAGATATTTTAAATGCTTTCAGGTATTTTAAGTGCTATATATATTATTTCGTCAGTC TAATTGTTTAGTGTTATTATCCTGAGTGGTTTTAGAAAATATTTCTTTGTTTTGTGGGTAGAATTTCTCC CTCTACTGATTTTTTTTTCTGTAACTTTACAGTTGTGACAGACATAAATCTGCTACTAATTATACTTGGT ATATTTTAAAAAGAGCCATTGTGTATTTCTATAAATAAACTTGCACAATGGTGGGCCTATCAGAGGTACT GAAAAATACTGTTCTTAACTATTTTAATATAAGGTATCTATTTTTAAGCACACAGGATTTCTCACAATGT TAAACAAAATGCCATTTCTTTAAAAGCAGAGACTGCTCTCACATGGTCACAATCCTTTGTTTTATTGTTG TTGCTATTCTTAAATCCCTTAATGTTGTGACAGAATATTTCCATGTGCTCCCTAATTTTGAGAATTAATT TGCAAGATTAAAAAAAACCCATATTAGTTATAGTAACTGGTCCTATAGTCATTATACTGGTATCTGGCTC TTCAACCGGTAAAATTCCACCTTCGTCCTGCAACAGGGGTCCTCCCATTGGTTTTACACACTTCAATTGA GTATATTTAAAATATTACTTCATTATACTTTGCATTTAAAAGGAACTAAACACATAGTTCTTATGTGAAT TTACTTCTGTAGAGCCTGTTGATTTAAGATTAGAAACAGTCCAGTTTGCCAAGGTTCAGAAATCAAACCA AGTTAGGACACTATACCAGATTTGTGGCATTTTAGTGCAAAAGATACATTTTCATTAAAAAGTACAATGT GGATGAACCGATAAATAGGTCAATAAAATAATTATTTGAGGTTTCATCTGGTTTACTCTTGATGTTGTAC AATCTGTAGGCTTGAACAAAGGTATAATAACATATATCTACCACTATAATATCAAACAGAGTGGTTTACT ACCCTAAAAACCCTGTTCTCCACCTGTTCATCCCTTCCTCCCACCACCTCCTGGTAACCACTGATCTTTC AACTGTCTCCATAGTTTTGCCTTTTCCAGATGTCATATAGTTGGAATCATACAGTATGTAGCCTTTTCAG GTTGGCTTCTTTCACTTAGTAATATGCATTTACGTTTCCTCCATATCTTTTCATGGCTTGATAGCCCTTT GTTAGAGTTGAATATTATTCCATTATCTGAATATACCACAGTTTATTTGTTCATTCAACTACTAAAGGAC ACTAGGTTGCTTCCAAGTTTTGGCAATTAATAAAGCTGCTATAAGCATCCACACACAGATTTTTGTGCAA GCATGTTTTCAGTTCTTTGAGTAAATGCCAAGGAACTAAATGTTGGATTGTATTGCATGTTTACTTTTGA AAGAAATTGCTAAATTGTCTTCCAAAGTGGCTGTGCCATTTTGCATTCGCACCAGCAATGAATTGGAGTT CTTGTTTCTTGACATATTCATCAGTATTTGGTGTCTTCAGCATTTAAATTTTAGCCATTCTAATGTGTGT AGTAGAATCTCATTGTTGTTTTAATTTGAAATTTCCTATAACATCTGATATTTATCATATTTTCTTTTTC GTTTGTTGTTTGAGACAGAGTCTCACTGTGTTGCCCAGGCTGAGCACCCACTATAGTTTAAGGAGAGAAA ACTGCTAGGAAATATTACAAGAAGTAACCCAAGGCTCCCTCTCTAGAGTTCAAGGCAGAGTAAGAGGTCT TGGCTTGAGATAAGTATTTTAAATTTGAGTGTGTGTGTGTGTGTGTGTCATACAAAGATTGAGAGAGACA AATTGAGAGAATTAATTTTTATCCTCAGGAGTGAATAAAATCATGTAGGGAAAGAGTGTTCATAGAAAAG CAAAGAGGACCAGGTATATCTCTGGAGTTTTCCAGCATGTTTATGGGTCTAGTCAAGGAAGAGGAGCCAG CCAAAGACATGAAGAAGAAGCTGCCAGTGAATGTGAGATAGGAGACCAGCCTGGAGGAGGAAATGTTTCA AGGAAAGCATGGCTGTGCTAGTTGCTGCTGAGGAAGGGATCAAGGAAAATGAGACAGAGATTTAGCCTTA GCAAACCATTGCTCATTGGCAGCCTCCATAAGATCTGTTTGACTGGAGTGATCAGATGAAAGCCTGATGG GAATGAGTTGTAGAGCAAATAGGAGGTCAAGAAAGTGGAGACAATGCAAGGCATATAATAACTCTTCTGA GGACTTTCCATTGAAAAGAGAAACAAGGTGGTAGCTGGAGAAAAAATAAGTATTATTTTTAGATGGGTAA TAACTGAGATATGTTTATATCTCAGAGTGATTCTGTTTCTGCAGTTGATATCAGTGACCATTTTAAGTCT CTTAAAATACTTTCATCCGTAATTTCTGTTACACAACACTTAATTGCTTCTCTTCCTACCTGGGCTGGTT TATTCTGTCCTTTTGCTCAGTCACCTACTCTCCAAGAGATGACTACCATGTATAGTTGTGCAGGTTGTAA ATGGTAGGAACATAAGCGGCACAGTTTACACCAACTACCTTGTAAATTGTGTCTCCAGAGTCATACCGTG CACACTTAGTCTAACTCTATGAGCTGACCCTTATTACCAGCCCCAGAACACAATTTTTATTTGAAGCACA TGGAAACAAATTCTATGTTGGTGTTGTGGGCCTACAGTAAGTAGTGGAAGCGTGGTTAACCAATCCTGAA GCTACACCACAGTAGCAATAATACTATACCTACAGAAGAAAAATGAATCAGATGCAGTAGAAAATGTTGG ATTCCTAAAAAATGTCCACCCCCAACTAAAATCATTGTCAAAAATAATAAAACAACAAGAGCTTTTCTCC CTCCATTTAGGCTTCATTTTCAAAGCAACAAACTGAAGTATAGGTAGTAAATTTCTACATTGAGAGTCAG TTTGCAAGTTGGAGAGAAAGCACTGCAAATCCACCCTGCCTGTTCAAAACATAAGAAGCACCAGTTAAAA TCTACCTATATTAGGGAAAAAAAGAAAAAAAAACTTCAATTAACAACTTGACTAAATGAAACAATTGAAA AAAATAGAATGTTCCTTACACATTACAACATGGATGAATCTCAAAACAGCTATCCTGAGTGAAAAGTCAG ACAACAATATAATTTATACTATATGATTACATTATATAAATTTTAGAAAATGCAAAGTATAGTAACACAA AGCAGATCAGTGGTTGCCTGTGGGGAGGAGAGGGGCAGCAGAAAGGGATTACCAAGGGGCACAAGGAAAC TTTTAGGGTGATGGACATGTTCATTATCTTGACTGGTCATGGTTTCATTGGTATATACATATGTCAAAAC TTATCAAACTGTATACTTTCAATACGTGCAGTTTTATTGTATGTCAATTAGATCTCCATGAAGCTGTAAA AAAAAAATGAAAAAAGGAAACTTGGTTTCTGAATGTCTGAAATTGATTTGTGTAGGTTTTCATCTAATAC TAAAAAGTGAGGGGCCAGTGCTGTGGCTCAGGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGTGC ATTGCTTGAGCTCAGTAGTTCAAGATCAGCTAGGCAACATGGTGAAATCCTATCTCTACCAAACATACAA AAATTAGCTGGGCGTGGTGGCTAATGCCTGCAGTCCCAGCTACTCAGGAGGCTGAGATGGGAGGATTGCT TGAGCCAAGTAGGTCAAGGCTTCAGTAAGCCATGGTCCTGCCACTGCACTCCAGCCTGGGCAATAGAGCT AGACTCTGTCTCAAAAGAGAGAGAAGGGGGCAGAAAGGAAGGGAGGGAAGGTATGGGGCGGGGGGAAGAG AGAGAGAGAGAGAAAGAGAGAGAGAGAAAGTGAGGCCGGCCATGGTGGCTCATGCCTGTAATCCCAGCAC TTTGGGAGGCCAAGGCAGGTGGATCATGAGGTCAGGAAATCAAGACCATCCTGGCCAACATGGTGAAACC CCATCTCTACTAAAAATACAAAAATTAGCTGGGCACCGTGGCGCATACCTGTAGTTCCAGCTACTTGGGA GGCTGAGGCAGGAGAATCCCTTGAATCCAGGAGGCAGAAGTTGAAGTGAACAGAGATCAGGCCACTGCAC TCCAGTCTGTTGATAGAGCGAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAGAAAGAAAAA GAAAGAAAAGAAAGTGAAAGCAATGCAAGGGTAAACATTTTGCAGAATAGCAGTGAAAATGTGATTAGAA TGTTACAAGATTCATAAAACCAACTGCCATTTAAAAACTGCAAGCAATTTCTTTCACATTCCAGTTGCAT TTACGAATCCACCTTTAAGGAAAGTATGTATGTTGTCTTTGCTTATTACCAGAACCCACAAAGCAGTATA TTTCTTTCGCCTCTATGACACCTTGAACTAGCTGGGGTTCCAAAGTTCATCATCTCTGCATATGTAACAA AAATTCATTTCAAATTCATCTTTGACAACTCTTATGAACAATGTCTTTGTAGTTCTTGCGGCTGTGTGAA CTAGTTTATCTCTGATTAAGGTTCATGCTGCATTTCCTGCTATATATGAACATTGTCCTGAAACCACTGC CTTTGTCTCATAAACATTTAAGGAATGGGTAAAGCAGGGACTAACAAGAACCAGAAGCAGCAACTCCTGG TTATACTTTTTTATTCCCTTTATCTTCCACTCCTAGTATACCTATGTAGCCTGTGGAAACATCATAAATT CTTGTTGACTGACACTGACAAACTTAATTAACTTACACATTTTACTTAACAACAACAATGACAACAAGAG AAGCAACATATTAACAATACTTTGAAATCATTGGGTGGACACACTAGGTGTGATCTACCATCCTCAGGGA TTTAAACTGCCCTTGTGCAAACATACTTTATAAATTGAAACCTGGCAGGCACCCAGGGAGTGGTTATGGT CTGCATTTATTGCTGAACTTTGGCCCAACACCCTCAAATGATTGGTGGCATTCTGGGAATAGTTAGCTGG GTGGAGATGAGCATGTCTCAGCAGAATAATTTGGTATTATTAGCATGACATTTGATATTAAATATAGTAT AATAATCAGGGATCACTGTTACTTGACTCAGAGAAGTCACAAACTTAAAAAGCATTAAAACAAGTTAATC CAAATTAGTCAAAAACAAATACAAGAATGACTCTGGTTCAATTTGATTGCTGATTAGATAATTAACAATT TTGAGAAATAAGCTTGATAATAATAGTTACTAGAGTAAAATAGGTTTTTATTGTTGTTGTTTTGTGTCTT TTCGGAGAGCTGAGCTAGGCTGGAGTTGGGGGAGAAGAGATGCTATAGGTATATGCTATACTGTTTTTTC TCTCCAGACCATGAATTTAATCAGTTACTGTTGTGCATATGTGGAAAATTACAAAATAAAACATTCTGTA ATTGATTGAATTTCATAGTTGACTACATAATTATGAAAGGAAATAAAATAGGACCACAAATGTTTATTTC TATCTTCCTAAGTCATAGGACAAAAAGATCTAGGCATCTACAATAGATCAAATAAAAAGAAGAAGTTAAC TTTTAATTTTCTTAAACTTTTGGAGGCATTGTTCAAGACAGATTGGTGACAGGAAATTGCATACTAATTT GTAGTGAAGACTAATAATCTCCAAGACTCTCTGAAGATTCAAATTCCTTCAGCCATTAGGAAGCTTTAAA AATGTAGAATATATACTTTTTAAAATCCAGACTTAAAAATGGAAACTTAGGTGGTAATTTACTGACTTTA AAGATGATTTTCTTTGTGTTTTAGATACCATTTACTTTCCTTGACTTTCCAGAAGGCCTGGGGAGGCAGA AAAACACATATAACTCTTGGCTGTATCTCTGTGTAACTTAGCTACTATAAATTCTGGACGACACGGGTCA TGGAGCAAATAAACTACACTTAGGCTACTGAGTTTCACAAAGCTATCTGGTTTTATGTTACTGTGTTATT CAGATTCATCTTAAATTGAAATTATCACAAAATATTCATTTGCATTTTCATTACTGGGTATAGTCTACTT ATTTTTTCATCAAAGCATTTAAATGTTATATTTGTCTGTTTCAGGACTCATGCCCGTTGCACAGCAGCCG GTTTATTGTGCTTCAAAGCATGGCATAGTTGGATTCACACGCTCAGCAGCGGTGAGGCTACAACAACCGT CATATCTCATTTTCTCTTTGTACACATTTATAAAACATGAATTCTGTAGAGAGGAATCACTTGAGAAATC ACTTGGATGAAAGGTGGAAAAATGACATACCTCCATCTCAATTATAAAAAGTTATCAGATCACATAAAGA ACCAAATAAATAATAGATCATTTTTAAATGAAGTGGATTCTAAATACAGATGTGTTATTTAAAAAAAATG TATTAAGGATAAGTAATGGGGAGATAGTACTTATTTCCAAAAATGACCCCAAATGGAAATATTATTAACT TCAGCTTTTCTGAAATGCAAGATGCAATAGGCCCCAGCCATTATTTGTCACCAGAGATACGATGAAAAGG AGTGAGAACATGGAGCTGGAAGGAGGGGTGGGGCCAGGCATTTACTTGATAGAGTGGTCAAGGATAATGT CTCCATGGAGGCCTAGGGTGAAAGGTGCACAGACCTTAGAAAAATACTTTAGACCTAATTGATCACATGC ATTGACAGCATGAGGTGAGAATGCCTGCCTTTTTATAACTCACAAAAGAGACGCTTGAAAGGGGCCTGGC AAGCAAAGGGAATGTAGTTTGAGGTATGACTCAAGACACCAGCACAGGAGCTAGACCAAAAGCAGCTATG GGCCACTGTTGTGAGCTTGGATTTTATTTCAAGGGCAACCATCCATGGGGCTTTTACACGCAGGAGTGAT AAGATCAGATTTCCTTTTTAAGAAGACCATTCTGTCTGCTTTTGCAAATTGTGTTACAAAAGACAAGTGT AAAAGCGGAAAGAACAGTTGTAGGGGGTCTCTGGGTGGTTCATCTAGGTGAGACAAAGAGAGCAGCTAGA GAGATGAAGAGAAAAATATTAGTAATCAAAGAATTAGTAGGAGACAGAAAAAACAGATGCACAAATGTTA ACTGTTCAGTCAAAATGGAAGATAAGTAGTTCTCACACTCTTAAATTGATTGGAAATTATTGCTTAATTT GCAAAGACATAATCTTCAGACAGACTTCTTATAAACACATAAAGCTCTCTTACAAAGCAAAGTAAACCTG AAAGACCAGAAATTTTATATTTAAAATTACAAGACTGGAAACTTCTACAGTCAATTCTCAGTATGCATGG TGGTTATGTTCCATGAAGTCACTTACAAACACTACATTAGTGACTACTGAACCATTGCTTTTAGGGGAAA TAGAGGGTTAAGTTCCTGAAAGCCTCTGGTCACAAAACTCCAATCAACCAGTCAATACATAACCTTATTT TATGTGTATTCCTGTTTAAAGAACCTTATTTATCATAGGTTGTATGAACATTGAACTCATTACTAAAGCA CTTATTACTCATGCCTGATCAAAATTTATCTAACACAAATATTTTCTGTACAGGACATCAGTCTTCTTAC ACTAAGGAACACTACACAGCACTTCTGCAGTGGGTTTGGCAGCCATTTTAAACAGCAGAATCACCAATAA AAAAGCACAAAATTAGAAAAACATGGCACGACAGAGTATAGTCTTACTTGACCTCAGCAGGAACATGCAC ATCGGTGACTCAAATTTCTCACTGCCCTGTGCATGTCCACAAATAACTACAAATGCTCCACAAGTATTGA TTTCCAGGGTTACAAGTAAATTTTAGCAAGCAAATTTAACAAATTTGTTTATATGTAATCCATGAATAAT GAGAATTGACTAATTTTTTAATAATTGCAAATAAAATCAATAGTTTGTAAATTAAGCCAAATAATGTTAG TCTGAAAATACTTAAATTGTCTTCCAGATAGGACAGATTATTAAGAGTGTCTTTAGAATCAAAGTTCTAA ACATTTTCACTAAAAGTCTTTTTAATTAAGTATTATTTGTTATACAACCACCATATTTGAAATAACACTT GGGATATCGATTCTAAGTCTCAGCTACTTAGCTTCAGGCTCCTGCAGAGTTCAGTAGATAAGAGAAGCTT ACATAATTGTTTCCAGGAGTTGTCCAGTAATACTGATTTTTAAAAAAAATTAATTAGGTGAGATTTTCAG GAATTAATACAATACTTTATGTATGTGTTATTTTACTATCTATTTACCAGTCATTGTTACATAGCTGGGA GGATATCTAATTAGTATTTTTTACATCAGAAAATTGTAAGATGCTTTAATGATCAGTTTGTCCTGTGCTA TATGTTTATGAAACTGCTGAAACCTACAACCTTCTAATTGGCAGTTGGCTGCTAATCTTATGAACAGTGG TGTGAGACTGAATGCCATTTGTCCAGGCTTTGTTAACACAGCCATCCTTGAATCAATTGAAAAAGAAGAA AACATGGGACAATATATAGAATATAAGGATCATATCAAGGATATGATTAAATACTATGGAATTTTGGAGT AAGTAAAACTATGTCTATTTTCTTTTAAATGATGAAGCAAAGCATTATTTAGATAAGCTATAAAAAGGGA AGAAATAAGCTTATACAGTTGAGAAATGAACACAAGCTTCAAACTTTTGGTTTGGCAAACTCTCTGGGAG AAAATATATTTTTCTGGGTTTATAAATAGAATGTAAGTTTATACATTATGAATGTTACTTTGAAATATGT AAAATGCTTCATTACTACCATCAGTCATAAAGTTGATATTTAGTCACCTTTGAAGGCAATGATACCTTCT CTGCCTAAATTCCAAGCAATATTCAAATATAGTCTGTGAAATATTGCAAGTTTCCATGACTTCAACCACT TTTATAAGAAATAGTTGATACACACACATACATGGACACATACTTTCTCAGTGAATTATGTCTGAATTCA AGCAACTGAGGATTTCATGAATCATAGTTATCATGTTGAAGGAATCAGACCTGAGATCAAATCTTGGCTC TACCACTAACCATGAACTTACCCATCATACCTCTAGATGCTTCAATTTTCTCACATATAAAATAGAGATA ATACAACAGACTTAGGGACTTTGAAAAACTTAAATAAAATGATACATACAAGGTACTTAAAATGGTAACT GGTAAAAAATAAAATTTTCAGTAAATGCTAGCTGTTACCAATCATATTTCTACACTAATAACATCTATAT CTGGTAAGTCTAAGATCTACTGATACGATAAAGATGAGAAAATGATCATTTGCTCAGTGAAAATAATGAG TATAAATTCCTCCTGCCAAAATGATGGAAGGTTACAGCTAAATTTATCAAATAATTTAGTTAATATCCAA TTGAAAGAAATCTAATTGAATAAATTAGATAAATAAGATATCTAATCTAGATATCTAATATGGAATTAAA TAAAAATTGGAAGTAGCAATAGTTTAATGACACACATTTCCCTATAACATGTTCAACTTAATAGATTCTT CAGAAAATAACTTAAAATGAAGTGGTAATATGCCTCATTCTTTCGTTTCAAAATACTGTTTTCTTTATTT TTAGCCCACCATTGATTGCCAATGGATTGATAACACTCATTGAAGATGATGCTTTAAATGGTGCTATTAT GAAGATCACAACTTCTAAGGGAATTCATTTTCAAGACTATGATACAACTCCATTTCAAGCAAAAACCCAA TGAACAGCTTATGTGTTAGCCATAGCTGAAAATAAGCACAAATAGCTTATATTCAGATCCTATCTTCATT TGAATATAGCTTTTAAATGAAATGTTACAGTTTGAAGTTTTCCTTCATGCACTTGGTGATAAACGTTTTC TAAATTTTTAGTTAAGTATATGGATAAAAAGTTATGAACTATTAAAAATGTGATGTGGACCAAAGGCTAG GTTGTAATCTTGATAGTCTAAAAAATGATCAAAACAAATGATTTTCAAGGAATATTCAATATTCTGCCTT TCAGAAAGTGTATTTATATCTGTGCTTCATAAATATTAATGTTCTTCAGAACATCATTTTAAAGGAGATA CTTGAATTGTTATTTAAATCAAACCAGATGTAAAACACTCACATACAAGTTCATACTTTAAAAGAGGAAA GCTACTTAACAATGACAAATATTTCACAATAATAATTTTTACTTATATACCATCTTTCAACTGAACATTT CAGTTCTTCCAAGAGCTTCTTAGAGTAGTATATTTTGGGGGCAGTCAAGGAATAAACTACAGTGTAAACA TATCCCAGATGAAAACTGCTGTATGGAAAAATGACAGAAAGTAACTGATTGACACTGTTGATTCACAGTT CAGCCTCCTATCTGGGAAAGACATTTCTTTCCTCTGCTCACTTTAAGAACTTTTACCGACTCCAAAAATC TCAGGAATTAAACTTTTAACAGTTACAGCAATAAAGAATAGTTAGTACTCCAAAAATATTATATTTAAGA TGCTCAACAAGAAAAAAATGCAAATGTAATATTTTTTTCAAATTACTTCTTTATTGACTTGTCCAAATTT CAAAAGTGCCTACCCTTCAATAAAACTTTTTTATTCTGATCTCCATAAATTACTTAGTCTTCTATGTATA GCTATCAAGGAAATAAAACCAATTTTGCCACAGCCACAACTGTAAATGTTTTTGTACCCATGCTGAAACT CATAACAACACAGACATAAAAATAGCTGTGAGGTTTTGCTTTTTTTGTTGTCAGCTATCTTAAGAATCAT TAAATACACCTGCTTTGGGTAAAACTCTTTGCAAGCAGTAATTAACACTAGTAACAGTGAAAGCACAAGA TTTCCAAATCAGTCGTTTTCTCAAAAAAATATCGTATAAGTGACTCATCCTGTCTGCTAACTCCAGACCT CCCAGCTTGAAGCCAAATCTTTCCATGTGAGATTGATATGGATTTCCTAGAAGTACTGGAATGTTGTCAT ATCTTGCCCTATTTTAATTCTGCTATAGAAAACAATTGCCTTCACTTTTAAGGAGTAATTTGAATATTAA TAACTCTGGTCTAGATTTTCATATAATGTATTAAAGACAAAGTAGTGAACATCAATGAACATCTGATAGA GATAAACTGTAATCAGGCATAAGCTTGTTTGTATGTTCTGGCAGTGACTAATCAGTAAATGATGTCGGTT TGCCCAGTATCACTTATCTTCTGTATTTTTCCTCTGTCGTGTAAATAGTATAACCTTTTCATTTATGGAC AATTTTTTGGACTAGTAGCCTTCAATATACATTCTGCTTTGAATTAATTTTTTCAAATCAATAAATTATG TAGACATTTAAAATCAAATATCAAGTAGAATTGAAAAATGTGAGTTACATAAGTTAAAAACTTACTTTAA ATCTTACCTTCTATAGGTAGCTCTAAATAAATTCATATGGTTATATGGCATCTCTGGTGTATACTGATTG AGAAAATAATTAAACTGAAGTTAGGGGAGGGG Download Select all
Length	32722
OMIM ID	601688
HGNC ID	HGNC:5154
Unigene ID	Hs.596913
Ensembl ID	ENSG00000164120
PharmGKB ID	-

mRNA Information

mRNA ID	NM_001256306.1
Exon	join(1..540,832..955,27275..27351,29585..29748, 30805..32722)
mRNA Sequence	>3248 GCTTTATTGTTTGCTTGTTTTGTTCCGGAGTCGGGGCCGGGAGGGAGTGCAGGAGGAGGGATCC AAGCTTCCAAGCCTCTGCTCCGCTCTCCTTCTATCCAGTTGGTCTTTAGGGCACTGAAGGAAAC TCTTCTTCAGAAATAACCTTTTAACTTTTCTTCTGTCAGCTGCCTGCCAATCACGGAGCCAGAG GCTGAGGGGAGGCTTTGAGCCGGTCTGCGAGTCCGGAAGGCAAAGATCGCGAAGCTTGGCGCTC CAGAACGCTCAGGGGGCAGGTGACACAGTCGTGGGTTCCCCGGCGGGCGCTGGCTTGACAGTTT CCTCCCCGCCCACTGGCAGGGGAGCGCCCCGCCGGGCTGCACGCGCGCGCGCGCAGGGGGGCAT AAAAGCCGCGGCCGCGCGGAGACGCGGAGCTCGCCCACCGCCCGCCCCAGCAGTGGCTGCACCA TGCACGTGAACGGCAAAGTGGCGCTGGTGACCGGCGCGGCTCAGGGCATAGGCAGAGCCTTTGC AGAGGCGCTGCTGCTTAAGGGCGCCAAGGTAGCGCTGGTGGATTGGAATCTTGAAGCAGGTGTA CAGTGTAAAGCTGCCCTGGATGAGCAGTTTGAACCTCAGAAGACTCTGTTCATCCAGTGCGATG TGGCTGACCAGCAACAACTGAGAGGACTCATGCCCGTTGCACAGCAGCCGGTTTATTGTGCTTC AAAGCATGGCATAGTTGGATTCACACGCTCAGCAGCGTTGGCTGCTAATCTTATGAACAGTGGT GTGAGACTGAATGCCATTTGTCCAGGCTTTGTTAACACAGCCATCCTTGAATCAATTGAAAAAG AAGAAAACATGGGACAATATATAGAATATAAGGATCATATCAAGGATATGATTAAATACTATGG AATTTTGGACCCACCATTGATTGCCAATGGATTGATAACACTCATTGAAGATGATGCTTTAAAT GGTGCTATTATGAAGATCACAACTTCTAAGGGAATTCATTTTCAAGACTATGATACAACTCCAT TTCAAGCAAAAACCCAATGAACAGCTTATGTGTTAGCCATAGCTGAAAATAAGCACAAATAGCT TATATTCAGATCCTATCTTCATTTGAATATAGCTTTTAAATGAAATGTTACAGTTTGAAGTTTT CCTTCATGCACTTGGTGATAAACGTTTTCTAAATTTTTAGTTAAGTATATGGATAAAAAGTTAT GAACTATTAAAAATGTGATGTGGACCAAAGGCTAGGTTGTAATCTTGATAGTCTAAAAAATGAT CAAAACAAATGATTTTCAAGGAATATTCAATATTCTGCCTTTCAGAAAGTGTATTTATATCTGT GCTTCATAAATATTAATGTTCTTCAGAACATCATTTTAAAGGAGATACTTGAATTGTTATTTAA ATCAAACCAGATGTAAAACACTCACATACAAGTTCATACTTTAAAAGAGGAAAGCTACTTAACA ATGACAAATATTTCACAATAATAATTTTTACTTATATACCATCTTTCAACTGAACATTTCAGTT CTTCCAAGAGCTTCTTAGAGTAGTATATTTTGGGGGCAGTCAAGGAATAAACTACAGTGTAAAC ATATCCCAGATGAAAACTGCTGTATGGAAAAATGACAGAAAGTAACTGATTGACACTGTTGATT CACAGTTCAGCCTCCTATCTGGGAAAGACATTTCTTTCCTCTGCTCACTTTAAGAACTTTTACC GACTCCAAAAATCTCAGGAATTAAACTTTTAACAGTTACAGCAATAAAGAATAGTTAGTACTCC AAAAATATTATATTTAAGATGCTCAACAAGAAAAAAATGCAAATGTAATATTTTTTTCAAATTA CTTCTTTATTGACTTGTCCAAATTTCAAAAGTGCCTACCCTTCAATAAAACTTTTTTATTCTGA TCTCCATAAATTACTTAGTCTTCTATGTATAGCTATCAAGGAAATAAAACCAATTTTGCCACAG CCACAACTGTAAATGTTTTTGTACCCATGCTGAAACTCATAACAACACAGACATAAAAATAGCT GTGAGGTTTTGCTTTTTTTGTTGTCAGCTATCTTAAGAATCATTAAATACACCTGCTTTGGGTA AAACTCTTTGCAAGCAGTAATTAACACTAGTAACAGTGAAAGCACAAGATTTCCAAATCAGTCG TTTTCTCAAAAAAATATCGTATAAGTGACTCATCCTGTCTGCTAACTCCAGACCTCCCAGCTTG AAGCCAAATCTTTCCATGTGAGATTGATATGGATTTCCTAGAAGTACTGGAATGTTGTCATATC TTGCCCTATTTTAATTCTGCTATAGAAAACAATTGCCTTCACTTTTAAGGAGTAATTTGAATAT TAATAACTCTGGTCTAGATTTTCATATAATGTATTAAAGACAAAGTAGTGAACATCAATGAACA TCTGATAGAGATAAACTGTAATCAGGCATAAGCTTGTTTGTATGTTCTGGCAGTGACTAATCAG TAAATGATGTCGGTTTGCCCAGTATCACTTATCTTCTGTATTTTTCCTCTGTCGTGTAAATAGT ATAACCTTTTCATTTATGGACAATTTTTTGGACTAGTAGCCTTCAATATACATTCTGCTTTGAA TTAATTTTTTCAAATCAATAAATTATGTAGACATTTAAAATCAAATATCAAGTAGAATTGAAAA ATGTGAGTTACATAAGTTAAAAACTTACTTTAAATCTTACCTTCTATAGGTAGCTCTAAATAAA TTCATATGGTTATATGGCATCTCTGGTGTATACTGATTGAGAAAATAATTAAACTGAAGTTAGG GGAGGGGAAAAAAAAAAAAAAAAA Download Select all
Length	2840

CDS Information

Location	join(448..540,832..955,27275..27351,29585..29748, 30805..30943)
CDS Sequence	>gi\|372626418:448-1044 Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) (HPGD), transcript variant 5, mRNA ATGCACGTGAACGGCAAAGTGGCGCTGGTGACCGGCGCGGCTCAGGGCATAGGCAGAGCCTTTGCAGAGG CGCTGCTGCTTAAGGGCGCCAAGGTAGCGCTGGTGGATTGGAATCTTGAAGCAGGTGTACAGTGTAAAGC TGCCCTGGATGAGCAGTTTGAACCTCAGAAGACTCTGTTCATCCAGTGCGATGTGGCTGACCAGCAACAA CTGAGAGGACTCATGCCCGTTGCACAGCAGCCGGTTTATTGTGCTTCAAAGCATGGCATAGTTGGATTCA CACGCTCAGCAGCGTTGGCTGCTAATCTTATGAACAGTGGTGTGAGACTGAATGCCATTTGTCCAGGCTT TGTTAACACAGCCATCCTTGAATCAATTGAAAAAGAAGAAAACATGGGACAATATATAGAATATAAGGAT CATATCAAGGATATGATTAAATACTATGGAATTTTGGACCCACCATTGATTGCCAATGGATTGATAACAC TCATTGAAGATGATGCTTTAAATGGTGCTATTATGAAGATCACAACTTCTAAGGGAATTCATTTTCAAGA CTATGATACAACTCCATTTCAAGCAAAAACCCAATGA Download Select all
CCDS ID	CCDS58934.1

Protein Information

Protein ID	NP_000851.2
Protein Name	Hydroxyprostaglandin dehydrogenase 15-(NAD)
Molecular Wt. (Da)	28846
Protein Sequence	>3248 MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCD VADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLDYMSKQNGG EGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNAICPGFVNTAILE SIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNGAIMKITTSKGIHFQDY DTTPFQAKTQ Download Select all
Length	266
Uniprot ID	P42574
Ensembl Protein ID	ENSP00000311032

Post-translational Modification Information (Source : HPRD)

No matching records could be found.

Enzyme Information

EC	1.1.1.141
Name	15-hydroxyprostaglandin dehydrogenase (NAD+) NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (type I) PGDH 11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase 15-OH-PGDH 15-hydroxyprostaglandin dehydrogenase 15-hydroxyprostanoic dehydrogenase NAD+-specific 15-hydroxyprostaglandin dehydrogenase prostaglandin dehydrogenase 15-hydroxyprostaglandin dehydrogenase (NAD+) (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase
Class	Oxidoreductases; Acting on the CH-OH group of donors; With NAD+ or NADP+ as acceptor
Sysname	(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate:NAD+ 15-oxidoreductase
Substrate	(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate; NAD+
Product	(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate; NADH; H+
Reaction (IUBMB)

PPi Information

(Click to view network : Source STRING) View

No matching records from HPRD source could be found.

Pathway Information

Pathway Name	Pathway ID
Transcriptional misregulation in cancer	hsa05202

Structure Information

PDB ID	2GDZ
Resolution	1.65
Method	X-RAY DIFFRACTION
Chains	A
Molecule	NAD+-dependent 15-hydroxyprostaglandin dehydrogenase
Model	View

Domain Information

ID	Location	Description
cd05323	6-254	ADH_SDR_c_like
cl21454	6-254	NADB_Rossmann superfamily
cd05233	8-246	SDR_c
cd05341	3-241	3beta-17beta-HSD_like_SDR_c
cd05333	6-237	BKR_SDR_c
cd08940	4-192	HBDH_SDR_c
cd05366	4-198	meso-BDH-like_SDR_c
cd05347	5-210	Ga5DH-like_SDR_c
cd05364	4-214	SDR_c11
cd05371	4-193	HSD10-like_SDR_c
cd05352	5-238	MDH-like_SDR_c
cd05330	6-245	cyclohexanol_reductase_SDR_c
cd05358	5-237	GlcDH_SDR_c
cd08932	6-208	HetN_like_SDR_c
PRK12935	3-237	PRK12935
cd05344	5-188	BKR_like_SDR_like
cd05326	5-191	secoisolariciresinol-DH_like_SDR_c
cd05363	3-195	SDH_SDR_c
cd05374	6-215	17beta-HSD-like_SDR_c
cd08934	5-202	CAD_SDR_c
cd05368	5-215	DHRS6_like_SDR_c
cd08944	3-193	SDR_c12
cd05345	1-245	BKR_3_SDR_c
cd08929	6-188	SDR_c4
PRK07069	8-194	PRK07069
cd05332	3-190	11beta-HSD1_like_SDR_c
cd08933	5-196	RDH_SDR_c
cd05355	5-203	SDR_c1
cd05324	6-208	carb_red_PTCR-like_SDR_c
cd05369	5-184	TER_DECR_SDR_a
cd05329	5-205	TR_SDR_c
cd05362	4-201	THN_reductase-like_SDR_c
cd08939	5-188	KDSR-like_SDR_c
cd05339	7-195	17beta-HSDXI-like_SDR_c
cd05360	7-188	SDR_c3
cd05359	8-199	ChcA_like_SDR_c
cd08930	4-184	SDR_c8
PRK06550	5-189	fabG
cd05343	5-192	Mgc4172-like_SDR_c
cd08935	4-189	mannonate_red_SDR_c
cd05357	6-245	PR_SDR_c
cd08931	6-200	SDR_c9
cd08945	6-194	PKR_SDR_c
cd05346	6-188	SDR_c5
cd09761	5-237	A3DFK9-like_SDR_c
cd05365	7-232	7_alpha_HSDH_SDR_c
cd05338	4-184	DHRS1_HSDL2-like_SDR_c
cd05350	8-194	SDR_c6
cd05327	5-191	retinol-DH_like_SDR_c_like
cd05370	1-193	SDR_c2
PRK07832	6-195	PRK07832
cd05367	7-243	SPR-like_SDR_c
cd08943	5-183	R1PA_ADH_SDR_c
cd05353	3-198	hydroxyacyl-CoA-like_DH_SDR_c-like
cd05331	8-237	DH-DHB-DH_SDR_c
cd05356	5-190	17beta-HSD1_like_SDR_c
cd05337	7-197	BKR_1_SDR_c
PRK09730	6-190	PRK09730
cd08942	3-208	RhlG_SDR_c
cd05348	4-188	BphB-like_SDR_c
cd08936	5-200	CR_SDR_c
PRK06947	6-190	PRK06947
cd05349	6-188	BKR_2_SDR_c
cd08937	5-188	DHB_DH-like_SDR_c
cd05351	5-188	XR_like_SDR_c
PRK06123	6-190	PRK06123
cd05322	5-184	SDH_SDR_c_like
cd05328	9-245	3alpha_HSD_SDR_c
cd05354	3-198	SDR_c7
PRK06924	6-245	PRK06924
cd09763	4-198	DHRS1-like_SDR_c
cd09807	5-188	retinol-DH_like_SDR_c
PRK07523	5-188	PRK07523
cd05340	3-199	Ycik_SDR_c
PRK08085	5-194	PRK08085
cd09806	6-212	type1_17beta-HSD-like_SDR_c
PRK06482	4-166	PRK06482
PRK12859	5-188	PRK12859
PRK05876	5-196	PRK05876
cd05334	5-188	DHPR_SDR_c_like
cd09805	6-200	type2_17beta_HSD-like_SDR_c
cd05325	8-188	carb_red_sniffer_like_SDR_c
PRK08251	6-190	PRK08251
cd09762	4-190	HSDL2_SDR_c
cd11731	8-190	Lin1944_like_SDR_c
PRK07023	8-194	PRK07023
pfam13561	12-203	adh_short_C2
PRK08945	4-189	PRK08945
cd05361	7-188	haloalcohol_DH_SDR_c-like
TIGR01500	7-236	sepiapter_red
cd05372	5-181	ENR_SDR
cd08953	May-98	KR_2_SDR_x
PRK12747	3-203	PRK12747
cd02266	8-193	SDR
PRK12428	54-191	PRK12428
PRK12746	2-190	PRK12746
cd09808	5-117	DHRS-12_like_SDR_c-like
PRK07806	Feb-92	PRK07806
PRK07533	5-188	PRK07533
PRK06720	Jan-94	PRK06720
PRK07904	9-188	PRK07904
PRK08340	Sep-93	PRK08340
cd05373	7-226	SDR_c10
cd08951	9-188	DR_C-13_KR_SDR_c_like
smart00822	6-153	PKS_KR
PRK08703	5-188	PRK08703
PRK08017	6-188	PRK08017
cd11730	8-188	Tthb094_like_SDR_c
PRK08416	2-193	PRK08416
pfam08659	Sep-94	KR
PRK07578	61-196	PRK07578
PRK08339	3-197	PRK08339
cd09810	Jun-94	LPOR_like_SDR_c_like
cd05247	Sep-82	UDP_G4E_1_SDR_e
PRK06483	9-186	PRK06483
PRK08303	May-91	PRK08303
cd09809	5-107	human_WWOX_like_SDR_c-like
PRK06101	7-188	PRK06101
PRK05854	May-94	PRK05854
PRK05993	6-196	PRK05993
PRK08862	1-189	PRK08862
PRK12367	4-110	PRK12367
PRK06079	1-188	PRK06079
cd05274	Sep-94	KR_FAS_SDR_x
PRK07453	Aug-94	PRK07453
cd05238	1-227	Gne_like_SDR_e
PRK08415	1-188	PRK08415
cd05226	Aug-98	SDR_e_a
cd08941	6-102	3KS_SDR_c
PRK08177	6-188	PRK08177
cd08950	May-32	KR_fFAS_SDR_c_like
cd05253	Sep-94	UDP_GE_SDE_e
cd05256	Sep-78	UDP_AE_SDR_e
PRK07102	97-188	PRK07102
cd05271	6-100	NDUFA9_like_SDR_a
cd05237	5-109	UDP_invert_4-6DH_SDR_e
PRK05565	1-245	fabG
PRK05653	1-214	fabG
COG1028	1-198	FabG
PRK12429	3-188	PRK12429
PRK07231	1-193	fabG
PRK05557	1-194	fabG
PRK12826	5-188	PRK12826
TIGR03971	3-237	SDR_subfam_1
PRK12829	5-210	PRK12829
PRK06841	4-190	PRK06841
PRK07067	1-188	PRK07067
PRK07825	3-188	PRK07825
PRK12825	1-198	fabG
PRK07326	1-188	PRK07326
COG0300	1-190	DltE
PRK08643	4-206	PRK08643
TIGR01830	8-202	3oxo_ACP_reduc
PRK06172	1-192	PRK06172
PRK07063	5-193	PRK07063
TIGR01963	5-192	PHB_DH
COG4221	1-203	YdfG
PRK08265	4-194	PRK08265
PRK06701	5-203	PRK06701
PRK12824	6-245	PRK12824
PRK06057	5-192	PRK06057
TIGR02415	6-198	23BDH
PRK05855	5-193	PRK05855
PRK06171	3-201	PRK06171
PRK06463	1-245	fabG
PRK12939	4-205	PRK12939
PRK06138	1-194	PRK06138
PRK07831	5-198	PRK07831
PRK06181	5-190	PRK06181
PRK12827	5-192	PRK12827
PRK13394	3-192	PRK13394
pfam00106	6-168	adh_short
PRK06484	5-197	PRK06484
PRK06484	5-245	PRK06484
PRK07454	6-193	PRK07454
PRK08226	5-199	PRK08226
PRK06935	4-204	PRK06935
PRK09242	4-205	PRK09242
PRK08213	5-197	PRK08213
PRK08217	1-200	fabG
PRK08277	3-185	PRK08277
TIGR01829	6-197	AcAcCoA_reduct
PRK06077	1-245	fabG
PRK06194	5-193	PRK06194
PRK07035	5-188	PRK07035
PRK08936	4-237	PRK08936
PRK07774	1-189	PRK07774
PRK12828	1-188	PRK12828
PRK07109	3-188	PRK07109
PRK08267	9-193	PRK08267
PLN02253	5-190	PLN02253
PRK07666	1-188	fabG
PRK06398	5-222	PRK06398
PRK05650	9-193	PRK05650
PRK06179	4-188	PRK06179
PRK12384	5-184	PRK12384
PRK06124	5-188	PRK06124
PRK06113	1-203	PRK06113
TIGR01832	4-204	kduD
PRK08324	5-183	PRK08324
PRK06914	4-254	PRK06914
PRK07856	4-188	PRK07856
PRK07792	3-183	fabG
PRK08220	1-199	PRK08220
PRK07060	1-188	PRK07060
TIGR04504	5-192	SDR_subfam_2
PRK08589	3-202	PRK08589
PRK07074	6-188	PRK07074
PRK06198	2-188	PRK06198
PRK05717	4-188	PRK05717
PRK12937	1-202	PRK12937
PRK06114	3-188	PRK06114
PRK08263	4-184	PRK08263
PRK08063	5-208	PRK08063
PRK08261	5-188	fabG
PRK08628	1-188	PRK08628
PRK05872	3-189	PRK05872
PRK06180	4-184	PRK06180
PRK07062	3-189	PRK07062
TIGR04316	8-202	dhbA_paeA
TIGR03206	3-197	benzo_BadH
PRK07478	1-190	PRK07478
TIGR02632	5-252	RhaD_aldol-ADH
PRK12743	6-188	PRK12743
PRK09135	1-184	PRK09135
PRK12745	6-188	PRK12745
COG3967	1-201	DltE
PRK09186	4-184	PRK09186
PRK06949	5-190	PRK06949
PRK12936	3-201	PRK12936
PRK12823	5-184	benD
PRK12481	3-204	PRK12481
PRK07814	3-205	PRK07814
PRK07791	3-183	PRK07791
TIGR03325	1-188	BphB_TodD
PRK06523	4-197	PRK06523
PRK05867	3-194	PRK05867
PRK06200	1-188	PRK06200
PRK06139	1-188	PRK06139
PRK08993	5-204	PRK08993
PRK06500	5-188	PRK06500
PRK12938	6-197	PRK12938
PRK08264	1-188	PRK08264
PRK12748	1-188	PRK12748
PRK07201	3-166	PRK07201
PRK06128	5-207	PRK06128
PRK09072	1-190	PRK09072
PRK07097	5-189	PRK07097
TIGR02685	7-184	pter_reduc_Leis
PRK08642	1-188	fabG
PRK08219	6-198	PRK08219
TIGR01831	9-197	fabG_rel
PRK07677	5-184	PRK07677
PRK06125	1-203	PRK06125
PRK07577	6-188	PRK07577
PRK07985	3-190	PRK07985
PRK06182	6-227	PRK06182
PRK07576	4-186	PRK07576
PRK10538	7-186	PRK10538
PRK08278	1-183	PRK08278
PRK06197	May-94	PRK06197
PRK07890	5-186	PRK07890
PRK05693	6-188	PRK05693
PRK12742	5-188	PRK12742
PRK05875	9-194	PRK05875
PRK05866	3-176	PRK05866
PRK06196	May-94	PRK06196
PRK09134	6-184	PRK09134
PRK07024	10-188	PRK07024
PRK05786	1-186	fabG
COG0623	4-188	FabI
PRK07370	5-200	PRK07370
PRK12744	1-188	PRK12744
PRK09291	5-188	PRK09291
PRK07424	May-95	PRK07424
PLN02780	5-188	PLN02780
PRK07041	9-198	PRK07041
PRK08159	5-188	PRK08159
COG0451	9-109	WcaG
COG1087	Sep-82	GalE
pfam01370	8-126	Epimerase

Ontology Information

HPRD ID	2799
Molecular Class	Enzyme: Dehydrogenase
Molecular Function	Cysteine-type peptidase activity (GO:0008234)
Biological Process	Apoptosis (GO:0006915)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO